| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,982,301 | +1,982,301 | 0.00 | 1.19 | +1.19 | buy |
| VR Adviser, LLC | 0 | 499,966 | +499,966 | 0.00 | 1.37 | +1.37 | buy |
| FCPM III SERVICES B.V. | 0 | 379,640 | +379,640 | 0.00 | 3.70 | +3.70 | buy |
| FMR LLC | 0 | 236,508 | +236,508 | 0.00 | 0.00 | +0.00 | buy |
| Ariose Capital Management Ltd | 0 | 110,173 | +110,173 | 0.00 | 1.80 | +1.80 | buy |
| VANGUARD GROUP INC | 0 | 105,190 | +105,190 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 75,909 | +75,909 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.09 | +0.09 | buy |
| BlackRock, Inc. | 0 | 34,530 | +34,530 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 27,392 | +27,392 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 27,363 | +27,363 | 0.00 | 0.01 | +0.01 | buy |
| Sarissa Capital Management LP | 0 | 25,399 | +25,399 | 0.00 | 0.69 | +0.69 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 24,764 | +24,764 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 21,248 | +21,248 | 0.00 | 0.14 | +0.14 | buy |
| JANE STREET GROUP, LLC | 0 | 16,753 | +16,753 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 15,786 | +15,786 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,600 | +14,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 9,054 | +9,054 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 8,104 | +8,104 | 0.00 | 0.02 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 6,250 | +6,250 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 0 | 6,097 | +6,097 | 0.00 | 0.10 | +0.10 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,075 | +6,075 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 5,686 | +5,686 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 4,729 | +4,729 | 0.00 | 0.00 | +0.00 | buy |
| Trustees of Columbia University in the City of New York | 0 | 4,595 | +4,595 | 0.00 | 0.03 | +0.03 | buy |
| Bollard Group LLC | 0 | 2,777 | +2,777 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| NBC SECURITIES, INC. | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,017 | 0 | -1,017 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,295 | 0 | -2,295 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 3,652 | 0 | -3,652 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 10,887 | 0 | -10,887 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 40,943 | 0 | -40,943 | 0.00 | 0.00 | -0.00 | sell |
| Bollard Group LLC | 55,555 | 0 | -55,555 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 72,417 | 0 | -72,417 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 87,485 | 0 | -87,485 | 0.00 | 0.00 | -0.00 | sell |
| Trustees of Columbia University in the City of New York | 91,910 | 0 | -91,910 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA SECURITIES, LLC | 94,394 | 0 | -94,394 | 0.02 | 0.00 | -0.02 | sell |
| STATE STREET CORP | 115,934 | 0 | -115,934 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 169,636 | 0 | -169,636 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 180,788 | 0 | -180,788 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 275,912 | 0 | -275,912 | 0.02 | 0.00 | -0.02 | sell |
| BlackRock, Inc. | 374,763 | 0 | -374,763 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 403,859 | 0 | -403,859 | 0.16 | 0.00 | -0.16 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 435,560 | 0 | -435,560 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 468,112 | 0 | -468,112 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 474,575 | 0 | -474,575 | 0.00 | 0.00 | -0.00 | sell |
| Sarissa Capital Management LP | 508,016 | 0 | -508,016 | 0.53 | 0.00 | -0.53 | sell |
| JANE STREET GROUP, LLC | 525,613 | 0 | -525,613 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON & JOHNSON | 1,074,658 | 53,732 | -1,020,926 | 0.34 | 0.52 | +0.18 | sell |
| UBS Group AG | 1,531,636 | 0 | -1,531,636 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,915,606 | 0 | -1,915,606 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,092,686 | 0 | -2,092,686 | 0.00 | 0.00 | -0.00 | sell |
| 5AM Venture Management, LLC | 6,361,723 | 0 | -6,361,723 | 3.96 | 0.00 | -3.96 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 39,646,039 | 0 | -39,646,039 | 1.08 | 0.00 | -1.08 | sell |