| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MAI Capital Management | 0 | 357,151 | +357,151 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 351,441 | 397,221 | +45,780 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 7,223 | 52,080 | +44,857 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 756,352 | 794,063 | +37,711 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 31,835 | +31,835 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 30,646 | +30,646 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,716,446 | 1,743,463 | +27,017 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 44,912 | 60,170 | +15,258 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 36,500 | 51,600 | +15,100 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 25,562 | 38,336 | +12,774 | 0.00 | 0.00 | +0.00 | buy |
| UNITED BANK | 0 | 10,900 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 10,050 | +10,050 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 18 | 5,737 | +5,719 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 17,258 | 21,296 | +4,038 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 14,523 | 18,038 | +3,515 | 0.00 | 0.00 | +0.00 | buy |
| BOURGEON CAPITAL MANAGEMENT LLC | 26,950 | 29,450 | +2,500 | 0.01 | 0.01 | +0.00 | buy |
| LMR Partners LLP | 48,780 | 51,111 | +2,331 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 605,907 | 608,007 | +2,100 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 797 | +797 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,111 | 3,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 15,894 | 15,894 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 162,700 | 162,700 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 22,748,880 | 22,748,880 | 0 | 0.95 | 0.80 | -0.15 | hold |
| Laurion Capital Management LP | 3,182,889 | 3,182,889 | 0 | 0.18 | 0.26 | +0.08 | hold |
| Bank of New York Mellon Corp | 108,209 | 108,209 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trustees of Columbia University in the City of New York | 91,910 | 91,910 | 0 | 0.36 | 0.44 | +0.08 | hold |
| Ensign Peak Advisors, Inc | 346,087 | 346,087 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bollard Group LLC | 55,555 | 55,555 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sarissa Capital Management LP | 618,000 | 618,000 | 0 | 0.18 | 0.21 | +0.04 | hold |
| Woodline Partners LP | 1,111,123 | 1,111,123 | 0 | 0.03 | 0.03 | -0.00 | hold |
| 5AM Venture Management, LLC | 6,361,723 | 6,361,723 | 0 | 3.88 | 3.80 | -0.08 | hold |
| Eagle Bay Advisors LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JOHNSON & JOHNSON | 1,074,658 | 1,074,658 | 0 | 0.84 | 0.06 | -0.78 | hold |
| Legal & General Group Plc | 3,627 | 3,627 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103,918 | 103,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 18,803 | 18,727 | -76 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 2,166 | 2,077 | -89 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,616 | 21,495 | -121 | 0.00 | 0.00 | +0.00 | sell |
| GRIMES & COMPANY, INC. | 13,986 | 13,656 | -330 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 3,664 | 3,286 | -378 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 17,996 | 17,320 | -676 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 44,902 | 42,990 | -1,912 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,313 | 6,201 | -2,112 | 0.00 | 0.00 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 6,461,467 | 6,457,293 | -4,174 | 0.93 | 0.68 | -0.25 | sell |
| Gladius Capital Management LP | 10,009 | 0 | -10,009 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,221 | 0 | -10,221 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 15,681 | 5,315 | -10,366 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 31,692 | 20,486 | -11,206 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 15,693 | 0 | -15,693 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 7,651,176 | 7,618,948 | -32,228 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,841 | 0 | -52,841 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 149,690 | 0 | -149,690 | 0.00 | 0.00 | -0.00 | sell |
| Artal Group S.A. | 2,688,015 | 2,347,424 | -340,591 | 0.25 | 0.18 | -0.07 | sell |
| BAKER BROS. ADVISORS LP | 633,848 | 0 | -633,848 | 0.01 | 0.00 | -0.01 | sell |