| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 22,748,880 | 39,646,039 | +16,897,159 | 0.18 | 0.59 | +0.40 | buy |
| Lynx1 Capital Management LP | 0 | 637,218 | +637,218 | 0.00 | 0.27 | +0.27 | buy |
| CITADEL ADVISORS LLC | 0 | 200,405 | +200,405 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 71,788 | +71,788 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 54,470 | +54,470 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 113,365 | 157,617 | +44,252 | 0.00 | 0.00 | +0.00 | buy |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 137,134 | 163,064 | +25,930 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 16,102 | +16,102 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,069 | +10,069 | 0.00 | 0.00 | +0.00 | buy |
| WEDBUSH SECURITIES INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 81,305 | 86,685 | +5,380 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,422 | +2,422 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,149 | +1,149 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 487,654 | 488,363 | +709 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 422,143 | 422,143 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UNITED BANK | 15,300 | 15,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Trustees of Columbia University in the City of New York | 91,910 | 91,910 | 0 | 0.44 | 0.02 | -0.42 | hold |
| Ensign Peak Advisors, Inc | 329,378 | 329,378 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 165,805 | 165,805 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bollard Group LLC | 55,555 | 55,555 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sarissa Capital Management LP | 618,000 | 618,000 | 0 | 0.11 | 0.21 | +0.10 | hold |
| LMR Partners LLP | 51,111 | 51,111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 6,361,723 | 6,361,723 | 0 | 0.92 | 1.69 | +0.77 | hold |
| Eagle Bay Advisors LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JOHNSON & JOHNSON | 1,074,658 | 1,074,658 | 0 | 0.18 | 0.31 | +0.13 | hold |
| Point72 (DIFC) Ltd | 26 | 26 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 11,024 | 11,024 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MONEY CONCEPTS CAPITAL CORP | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 44,728 | 44,728 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 115,934 | 115,934 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 5,053 | 4,569 | -484 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 528 | 0 | -528 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,298 | 3,601 | -697 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 3,759 | 3,045 | -714 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 29,530 | 28,090 | -1,440 | 0.00 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 28,227 | 26,698 | -1,529 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 135,900 | 132,600 | -3,300 | 0.00 | 0.00 | +0.00 | sell |
| Catalyst Funds Management Pty Ltd | 9,800 | 0 | -9,800 | 0.00 | 0.00 | -0.00 | sell |
| CHIRON CAPITAL MANAGEMENT, LLC | 11,000 | 0 | -11,000 | 0.01 | 0.00 | -0.01 | sell |
| VANGUARD GROUP INC | 1,954,285 | 1,942,821 | -11,464 | 0.00 | 0.00 | +0.00 | sell |
| Chicago Partners Investment Group LLC | 13,593 | 0 | -13,593 | 0.00 | 0.00 | -0.00 | sell |
| GRIMES & COMPANY, INC. | 15,142 | 0 | -15,142 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,792 | 0 | -17,792 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 50,300 | 27,500 | -22,800 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 24,219 | 0 | -24,219 | 0.00 | 0.00 | -0.00 | sell |
| Ground Swell Capital, LLC | 26,103 | 0 | -26,103 | 0.03 | 0.00 | -0.03 | sell |
| Laurion Capital Management LP | 28,981 | 0 | -28,981 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 30,825 | 0 | -30,825 | 0.00 | 0.00 | -0.00 | sell |
| NOMURA HOLDINGS INC | 41,495 | 0 | -41,495 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 303,825 | 261,837 | -41,988 | 0.00 | 0.00 | +0.00 | sell |
| Rosalind Advisors, Inc. | 76,685 | 0 | -76,685 | 0.04 | 0.00 | -0.04 | sell |
| MARSHALL WACE, LLP | 116,635 | 37,190 | -79,445 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 475,891 | 283,199 | -192,692 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 756,011 | 529,500 | -226,511 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 7,071,110 | 6,419,633 | -651,477 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 2,466,236 | 0 | -2,466,236 | 0.01 | 0.00 | -0.01 | sell |