| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,982,301 | 5,404,998 | +3,422,697 | 1.19 | 0.72 | -0.47 | buy |
| FCPM III SERVICES B.V. | 379,640 | 3,617,354 | +3,237,714 | 3.70 | 6.20 | +2.51 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 2,543,939 | +2,543,939 | 0.00 | 0.89 | +0.89 | buy |
| FMR LLC | 236,508 | 2,526,170 | +2,289,662 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,750,000 | +1,750,000 | 0.00 | 0.61 | +0.61 | buy |
| VR Adviser, LLC | 499,966 | 1,943,766 | +1,443,800 | 1.37 | 1.26 | -0.12 | buy |
| GREAT POINT PARTNERS LLC | 0 | 1,370,107 | +1,370,107 | 0.00 | 5.81 | +5.81 | buy |
| Caligan Partners LP | 0 | 925,067 | +925,067 | 0.00 | 0.91 | +0.91 | buy |
| VANGUARD GROUP INC | 105,190 | 770,250 | +665,060 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 34,530 | 465,636 | +431,106 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 5,686 | 433,894 | +428,208 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 410,417 | +410,417 | 0.00 | 1.12 | +1.12 | buy |
| Laurion Capital Management LP | 0 | 317,243 | +317,243 | 0.00 | 0.28 | +0.28 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 0 | 231,000 | +231,000 | 0.00 | 1.00 | +1.00 | buy |
| UBS Group AG | 75,909 | 292,118 | +216,209 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 24,764 | 224,534 | +199,770 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 167,673 | +167,673 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 163,061 | +163,061 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 27,392 | 185,808 | +158,416 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 15,786 | 145,640 | +129,854 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 100,000 | +100,000 | 0.00 | 0.09 | +0.09 | buy |
| STATE STREET CORP | 9,054 | 91,053 | +81,999 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 16,753 | 91,810 | +75,057 | 0.00 | 0.00 | +0.00 | buy |
| JOHNSON & JOHNSON | 0 | 53,732 | +53,732 | 0.00 | 0.13 | +0.13 | buy |
| NORTHERN TRUST CORP | 0 | 38,946 | +38,946 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 28,204 | +28,204 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 26,791 | +26,791 | 0.00 | 0.00 | +0.00 | buy |
| Bollard Group LLC | 2,777 | 23,987 | +21,210 | 0.00 | 0.01 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 20,700 | +20,700 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 17,542 | +17,542 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 4,729 | 18,459 | +13,730 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 10,798 | +10,798 | 0.00 | 0.07 | +0.07 | buy |
| Shay Capital LLC | 0 | 10,745 | +10,745 | 0.00 | 0.02 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 10,207 | +10,207 | 0.00 | 0.00 | +0.00 | buy |
| Chung Wu Investment Group, LLC | 0 | 8,300 | +8,300 | 0.00 | 0.09 | +0.09 | buy |
| CITIGROUP INC | 0 | 6,340 | +6,340 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 5,110 | +5,110 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 2,746 | +2,746 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,729 | +1,729 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1,399 | +1,399 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 819 | +819 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 330 | +330 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sarissa Capital Management LP | 25,399 | 25,399 | 0 | 0.69 | 0.15 | -0.54 | hold |
| SBI Securities Co., Ltd. | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caitong International Asset Management Co., Ltd | 110 | 0 | -110 | 0.00 | 0.00 | -0.00 | sell |
| Trustees of Columbia University in the City of New York | 4,595 | 0 | -4,595 | 0.03 | 0.00 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,075 | 291 | -5,784 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 6,097 | 0 | -6,097 | 0.10 | 0.00 | -0.10 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 6,250 | 0 | -6,250 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 8,104 | 0 | -8,104 | 0.02 | 0.00 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 14,600 | 0 | -14,600 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 21,248 | 0 | -21,248 | 0.14 | 0.00 | -0.14 | sell |
| Woodline Partners LP | 27,363 | 0 | -27,363 | 0.01 | 0.00 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 0 | -50,000 | 0.09 | 0.00 | -0.09 | sell |
| JOHNSON & JOHNSON | 53,732 | 0 | -53,732 | 0.52 | 0.00 | -0.52 | sell |
| Ariose Capital Management Ltd | 110,173 | 0 | -110,173 | 1.80 | 0.00 | -1.80 | sell |