| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 1,046,353 | 1,245,511 | +199,158 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 315,758 | 410,457 | +94,699 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 103,635 | 145,089 | +41,454 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 0 | 29,281 | +29,281 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 117,112 | 141,676 | +24,564 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 11,547 | +11,547 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 43,526 | 54,881 | +11,355 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 164,783 | 171,783 | +7,000 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 38,070 | 41,952 | +3,882 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,039 | 11,477 | +3,438 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,879 | 13,230 | +3,351 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 900 | 3,555 | +2,655 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 7,289 | 9,738 | +2,449 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 12,879 | 14,493 | +1,614 | 0.00 | 0.00 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 44,000 | 45,456 | +1,456 | 0.45 | 0.16 | -0.29 | buy |
| Tower Research Capital LLC (TRC) | 1,212 | 2,614 | +1,402 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 1,393 | 2,018 | +625 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 43 | 164 | +121 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 510 | 603 | +93 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 132 | 185 | +53 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 520,301 | 520,327 | +26 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 809 | 813 | +4 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,424 | 1,424 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,041 | 1,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | 9,853,302 | 0 | 1.32 | 0.49 | -0.83 | hold |
| Bank of New York Mellon Corp | 33,305 | 33,305 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 1,609,569 | 1,609,569 | 0 | 1.11 | 0.41 | -0.70 | hold |
| Samsara BioCapital, LLC | 291,666 | 291,666 | 0 | 0.40 | 0.16 | -0.25 | hold |
| Woodline Partners LP | 283,124 | 283,124 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Logos Global Management LP | 145,089 | 145,089 | 0 | 0.17 | 0.08 | -0.09 | hold |
| 5AM Venture Management, LLC | 2,353,304 | 2,353,304 | 0 | 5.66 | 2.67 | -2.99 | hold |
| Police & Firemen's Retirement System of New Jersey | 3,477 | 3,477 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,937 | 2,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | 194,108 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 480 | 480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 21,423 | 21,423 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 216 | 158 | -58 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 224 | 0 | -224 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,150 | 4,872 | -278 | 0.00 | 0.00 | -0.00 | sell |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 900 | 400 | -500 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 15,606 | 14,338 | -1,268 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 24,161 | 22,753 | -1,408 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 8,616 | 0 | -8,616 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 866,925 | 858,214 | -8,711 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 8,733 | 0 | -8,733 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 37,619 | 17,883 | -19,736 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 35,379 | 0 | -35,379 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 41,453 | 0 | -41,453 | 0.02 | 0.00 | -0.02 | sell |
| Capital World Investors | 915,386 | 866,622 | -48,764 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 103,633 | 0 | -103,633 | 0.06 | 0.00 | -0.06 | sell |
| RTW INVESTMENTS, LP | 148,844 | 0 | -148,844 | 0.02 | 0.00 | -0.02 | sell |
| venBio Partners LLC | 1,519,971 | 1,198,975 | -320,996 | 8.98 | 2.91 | -6.06 | sell |