| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Propel Bio Management, LLC | 0 | 146,369 | +146,369 | 0.00 | 0.60 | +0.60 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 30,702 | +30,702 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 25,000 | +25,000 | 0.00 | 0.10 | +0.10 | buy |
| Simplify Asset Management Inc. | 0 | 23,230 | +23,230 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 20,700 | +20,700 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 20,370 | +20,370 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 20,270 | +20,270 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 12,208 | +12,208 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 212,538 | 213,388 | +850 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 101,117 | 101,695 | +578 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 542 | 542 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | 9,853,302 | 0 | 0.43 | 0.67 | +0.24 | hold |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 1,609,569 | 1,609,569 | 0 | 0.34 | 0.39 | +0.05 | hold |
| Russell Investments Group, Ltd. | 5,491 | 5,491 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 2,353,304 | 2,353,304 | 0 | 3.17 | 4.21 | +1.03 | hold |
| FRANKLIN RESOURCES INC | 520,327 | 520,327 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | 194,108 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 35,824 | 35,824 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 3,558 | 3,529 | -29 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,103 | 0 | -1,103 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 21,100 | 11,400 | -9,700 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,691 | 0 | -10,691 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 27,757 | 0 | -27,757 | 0.07 | 0.00 | -0.07 | sell |
| TWO SIGMA INVESTMENTS, LP | 144,864 | 115,041 | -29,823 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 116,200 | 80,038 | -36,162 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 79,559 | 0 | -79,559 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 217,097 | 123,270 | -93,827 | 0.00 | 0.00 | -0.00 | sell |
| venBio Partners LLC | 648,507 | 531,337 | -117,170 | 1.29 | 1.22 | -0.07 | sell |