| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | 327,067 | +327,067 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 77,656 | +77,656 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 41,952 | 118,003 | +76,051 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 52,213 | +52,213 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 41,395 | +41,395 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,555 | 42,277 | +38,722 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 38,692 | +38,692 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 31,567 | +31,567 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 24,849 | +24,849 | 0.00 | 0.06 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 21,371 | +21,371 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 17,171 | +17,171 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 145,089 | 153,739 | +8,650 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,614 | 10,098 | +7,484 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 5,491 | +5,491 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 164 | 329 | +165 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 813 | 941 | +128 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,872 | 4,893 | +21 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | 9,853,302 | 0 | 0.49 | 0.25 | -0.24 | hold |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 45,456 | 45,456 | 0 | 0.16 | 0.10 | -0.06 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 1,609,569 | 1,609,569 | 0 | 0.41 | 0.18 | -0.23 | hold |
| Samsara BioCapital, LLC | 291,666 | 291,666 | 0 | 0.16 | 0.09 | -0.07 | hold |
| Woodline Partners LP | 283,124 | 283,124 | 0 | 0.01 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 2,353,304 | 2,353,304 | 0 | 2.67 | 1.37 | -1.30 | hold |
| GF FUND MANAGEMENT CO. LTD. | 603 | 603 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 520,327 | 520,327 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | 194,108 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 158 | 0 | -158 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 185 | 0 | -185 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 480 | 0 | -480 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,041 | 0 | -1,041 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,424 | 0 | -1,424 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 2,018 | 0 | -2,018 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,937 | 0 | -2,937 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 3,477 | 0 | -3,477 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 9,738 | 0 | -9,738 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 14,338 | 3,567 | -10,771 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,477 | 0 | -11,477 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 11,547 | 0 | -11,547 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 13,230 | 814 | -12,416 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 14,493 | 0 | -14,493 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 17,883 | 0 | -17,883 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 21,423 | 3,383 | -18,040 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 22,753 | 1,906 | -20,847 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 29,281 | 0 | -29,281 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 33,305 | 0 | -33,305 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 47,892 | 0 | -47,892 | 0.00 | 0.00 | -0.00 | sell |
| venBio Partners LLC | 1,198,975 | 1,148,975 | -50,000 | 2.91 | 1.51 | -1.40 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 54,881 | 0 | -54,881 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 141,676 | 34,964 | -106,712 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 171,783 | 62,874 | -108,909 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 145,089 | 0 | -145,089 | 0.08 | 0.00 | -0.08 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 410,457 | 159,041 | -251,416 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 858,214 | 232,972 | -625,242 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 1,245,511 | 485,727 | -759,784 | 0.00 | 0.00 | -0.00 | sell |
| Capital World Investors | 866,622 | 0 | -866,622 | 0.00 | 0.00 | -0.00 | sell |