| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | 17,955,642 | +8,102,340 | 0.67 | 1.51 | +0.84 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 2,604,166 | +2,604,166 | 0.00 | 0.07 | +0.07 | buy |
| Blackstone Inc. | 0 | 2,403,437 | +2,403,437 | 0.00 | 0.08 | +0.08 | buy |
| Caligan Partners LP | 0 | 1,736,111 | +1,736,111 | 0.00 | 0.81 | +0.81 | buy |
| FRANKLIN RESOURCES INC | 520,327 | 1,997,223 | +1,476,896 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 0 | 954,861 | +954,861 | 0.00 | 0.76 | +0.76 | buy |
| Blue Owl Capital Holdings LP | 0 | 874,542 | +874,542 | 0.00 | 1.29 | +1.29 | buy |
| CITADEL ADVISORS LLC | 0 | 609,376 | +609,376 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 146,369 | 696,436 | +550,067 | 0.60 | 3.54 | +2.94 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 525,000 | +525,000 | 0.00 | 0.57 | +0.57 | buy |
| BlackRock, Inc. | 213,388 | 694,726 | +481,338 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 1,609,569 | 2,043,596 | +434,027 | 0.39 | 0.60 | +0.21 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 314,375 | +314,375 | 0.00 | 0.06 | +0.06 | buy |
| Nantahala Capital Management, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.18 | +0.18 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 260,416 | +260,416 | 0.00 | 1.76 | +1.76 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 101,695 | 353,845 | +252,150 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 184,020 | +184,020 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 175,000 | +175,000 | 0.00 | 0.07 | +0.07 | buy |
| Alyeska Investment Group, L.P. | 100,000 | 273,615 | +173,615 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 35,824 | 165,764 | +129,940 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 118,624 | +118,624 | 0.00 | 0.05 | +0.05 | buy |
| Simplify Asset Management Inc. | 23,230 | 101,355 | +78,125 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 80,038 | 151,000 | +70,962 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 67,101 | +67,101 | 0.00 | 0.12 | +0.12 | buy |
| NORTHERN TRUST CORP | 12,208 | 76,423 | +64,215 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 35,000 | 85,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 49,345 | +49,345 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 20,370 | 44,815 | +24,445 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 22,940 | +22,940 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 22,854 | +22,854 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 20,270 | 42,509 | +22,239 | 0.00 | 0.01 | +0.00 | buy |
| Spark Investment Management LLC | 0 | 16,500 | +16,500 | 0.00 | 0.31 | +0.31 | buy |
| Squarepoint Ops LLC | 0 | 14,855 | +14,855 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 13,980 | +13,980 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 11,896 | +11,896 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 11,896 | +11,896 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,100 | +6,100 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 4,588 | +4,588 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 3,336 | +3,336 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 3,039 | +3,039 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 2,143 | +2,143 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 2,136 | +2,136 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 1,600 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 542 | 1,148 | +606 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 566 | +566 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 421 | +421 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 247 | +247 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 235 | +235 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 94 | +94 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 72 | +72 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,529 | 3,558 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 2,353,304 | 2,353,304 | 0 | 4.21 | 7.93 | +3.72 | hold |
| Velan Capital Investment Management LP | 25,000 | 25,000 | 0 | 0.10 | 0.15 | +0.05 | hold |
| BAILARD, INC. | 20,700 | 20,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | 194,108 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 5,491 | 0 | -5,491 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 11,400 | 0 | -11,400 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 30,702 | 0 | -30,702 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 115,041 | 78,575 | -36,466 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 123,270 | 0 | -123,270 | 0.00 | 0.00 | -0.00 | sell |
| venBio Partners LLC | 531,337 | 0 | -531,337 | 1.22 | 0.00 | -1.22 | sell |