| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 9,853,302 | +9,853,302 | 0.00 | 1.76 | +1.76 | buy |
| 5AM Venture Management, LLC | 0 | 2,353,304 | +2,353,304 | 0.00 | 7.51 | +7.51 | buy |
| VR Adviser, LLC | 0 | 1,609,569 | +1,609,569 | 0.00 | 1.30 | +1.30 | buy |
| venBio Partners LLC | 0 | 1,519,971 | +1,519,971 | 0.00 | 12.08 | +12.08 | buy |
| Capital World Investors | 0 | 915,386 | +915,386 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 841,005 | +841,005 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 520,301 | +520,301 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 308,930 | +308,930 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 0 | 291,666 | +291,666 | 0.00 | 0.87 | +0.87 | buy |
| Woodline Partners LP | 0 | 283,124 | +283,124 | 0.00 | 0.04 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 194,108 | +194,108 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 148,844 | +148,844 | 0.00 | 0.03 | +0.03 | buy |
| Logos Global Management LP | 0 | 145,089 | +145,089 | 0.00 | 0.24 | +0.24 | buy |
| NORTHERN TRUST CORP | 0 | 112,777 | +112,777 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 103,635 | +103,635 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 103,633 | +103,633 | 0.00 | 0.08 | +0.08 | buy |
| Alyeska Investment Group, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 0 | 86,559 | +86,559 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 44,000 | +44,000 | 0.00 | 0.55 | +0.55 | buy |
| EcoR1 Capital, LLC | 0 | 41,453 | +41,453 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 40,293 | +40,293 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 31,209 | +31,209 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 29,547 | +29,547 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 19,616 | +19,616 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 14,829 | +14,829 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 10,726 | +10,726 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 10,181 | +10,181 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 8,733 | +8,733 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 7,659 | +7,659 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 7,515 | +7,515 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 5,255 | +5,255 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 2,937 | +2,937 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,728 | +2,728 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 2,600 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,424 | +1,424 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,393 | +1,393 | 0.00 | 0.00 | +0.00 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 0 | 1,300 | +1,300 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,041 | +1,041 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 720 | +720 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 480 | +480 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |