| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | 9,853,302 | 0 | 0.25 | 0.35 | +0.10 | hold |
| 5AM Venture Management, LLC | 2,353,304 | 2,353,304 | 0 | 1.37 | 2.47 | +1.11 | hold |
| VR Adviser, LLC | 1,609,569 | 1,609,569 | 0 | 0.18 | 0.26 | +0.08 | hold |
| venBio Partners LLC | 1,148,975 | 1,148,975 | 0 | 1.51 | 1.87 | +0.36 | hold |
| CITADEL ADVISORS LLC | 153,739 | 798,397 | +644,658 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 520,327 | 520,327 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BlackRock, Inc. | 485,727 | 294,422 | -191,305 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 327,067 | 262,160 | -64,907 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | 194,108 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VANGUARD GROUP INC | 232,972 | 159,118 | -73,854 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 814 | 118,547 | +117,733 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 159,041 | 110,896 | -48,145 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 3,567 | 105,573 | +102,006 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 79,147 | +79,147 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 62,874 | 59,824 | -3,050 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 118,003 | 49,777 | -68,226 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 47,973 | +47,973 | 0.00 | 0.01 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 39,133 | +39,133 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HRT FINANCIAL LP | 77,656 | 26,953 | -50,703 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 38,692 | 25,552 | -13,140 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 21,371 | 20,364 | -1,007 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 14,302 | +14,302 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,906 | 12,696 | +10,790 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,098 | 9,981 | -117 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 5,491 | 5,491 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 42,277 | 4,920 | -37,357 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 4,893 | 4,281 | -612 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 941 | 944 | +3 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 603 | 510 | -93 | 0.00 | 0.00 | +0.00 | sell |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 0 | 159 | +159 | 0.00 | 0.00 | +0.00 | buy |
| Cloud Capital Management, LLC | 0 | 11 | +11 | 0.00 | 0.00 | 0.00 | buy |
| MARSHALL WACE, LLP | 52,213 | 0 | -52,213 | 0.00 | 0.00 | -0.00 | sell |
| Ground Swell Capital, LLC | 24,849 | 0 | -24,849 | 0.06 | 0.00 | -0.06 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 45,456 | 0 | -45,456 | 0.10 | 0.00 | -0.10 | sell |
| Squarepoint Ops LLC | 41,395 | 0 | -41,395 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 291,666 | 0 | -291,666 | 0.09 | 0.00 | -0.09 | sell |
| Y-Intercept (Hong Kong) Ltd | 31,567 | 0 | -31,567 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 283,124 | 0 | -283,124 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 17,171 | 0 | -17,171 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 34,964 | 0 | -34,964 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 329 | 0 | -329 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 3,383 | 0 | -3,383 | 0.00 | 0.00 | -0.00 | sell |