| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | 9,853,302 | 0 | 1.76 | 1.32 | -0.43 | hold |
| 5AM Venture Management, LLC | 2,353,304 | 2,353,304 | 0 | 7.51 | 5.66 | -1.85 | hold |
| VR Adviser, LLC | 1,609,569 | 1,609,569 | 0 | 1.30 | 1.11 | -0.19 | hold |
| venBio Partners LLC | 1,519,971 | 1,519,971 | 0 | 12.08 | 8.98 | -3.11 | hold |
| BlackRock, Inc. | 837,613 | 1,046,353 | +208,740 | 0.00 | 0.00 | -0.00 | buy |
| Capital World Investors | 915,386 | 915,386 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VANGUARD GROUP INC | 841,005 | 866,925 | +25,920 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 520,301 | 520,301 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 308,930 | 315,758 | +6,828 | 0.00 | 0.00 | -0.00 | buy |
| Samsara BioCapital, LLC | 291,666 | 291,666 | 0 | 0.87 | 0.40 | -0.46 | hold |
| Woodline Partners LP | 283,124 | 283,124 | 0 | 0.04 | 0.02 | -0.02 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | 194,108 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 86,559 | 164,783 | +78,224 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 148,844 | 148,844 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Logos Global Management LP | 145,089 | 145,089 | 0 | 0.24 | 0.17 | -0.07 | hold |
| NORTHERN TRUST CORP | 112,777 | 117,112 | +4,335 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 103,635 | 103,635 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 103,633 | 103,633 | 0 | 0.08 | 0.06 | -0.03 | hold |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 44,000 | 44,000 | 0 | 0.55 | 0.45 | -0.10 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,293 | 43,526 | +3,233 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 41,453 | 41,453 | 0 | 0.02 | 0.02 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 29,547 | 38,070 | +8,523 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 10,726 | 37,619 | +26,893 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 35,379 | +35,379 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 31,209 | 33,305 | +2,096 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 19,616 | 24,161 | +4,545 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 21,423 | +21,423 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 10,181 | 15,606 | +5,425 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 14,829 | 12,879 | -1,950 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,728 | 9,879 | +7,151 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 8,733 | 8,733 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 5,255 | 8,616 | +3,361 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,659 | 8,039 | +380 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 7,515 | 7,289 | -226 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 0 | 5,150 | +5,150 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,937 | 2,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,424 | 1,424 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,393 | 1,393 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 720 | 1,212 | +492 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,041 | 1,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 1,300 | 900 | -400 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 160 | 900 | +740 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 809 | +809 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 480 | 480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 0 | 224 | +224 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 31 | 216 | +185 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 132 | +132 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 43 | +43 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 2,600 | 0 | -2,600 | 0.00 | 0.00 | -0.00 | sell |