| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TWO SIGMA INVESTMENTS, LP | 20,364 | 144,864 | +124,500 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 159,118 | 246,006 | +86,888 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 79,559 | +79,559 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 79,147 | 116,200 | +37,053 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 27,757 | +27,757 | 0.00 | 0.07 | +0.07 | buy |
| OMERS ADMINISTRATION Corp | 0 | 21,100 | +21,100 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | 9,853,302 | 0 | 0.35 | 0.43 | +0.08 | hold |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 1,609,569 | 1,609,569 | 0 | 0.26 | 0.34 | +0.08 | hold |
| Russell Investments Group, Ltd. | 5,491 | 5,491 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 2,353,304 | 2,353,304 | 0 | 2.47 | 3.17 | +0.70 | hold |
| FRANKLIN RESOURCES INC | 520,327 | 520,327 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | 194,108 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cloud Capital Management, LLC | 11 | 0 | -11 | 0.00 | 0.00 | 0.00 | sell |
| EverSource Wealth Advisors, LLC | 159 | 0 | -159 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 510 | 0 | -510 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 944 | 0 | -944 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 4,920 | 3,558 | -1,362 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 14,302 | 10,691 | -3,611 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 4,281 | 0 | -4,281 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,981 | 1,103 | -8,878 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 110,896 | 101,117 | -9,779 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 12,696 | 0 | -12,696 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 59,824 | 35,824 | -24,000 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 25,552 | 0 | -25,552 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 26,953 | 0 | -26,953 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 39,133 | 0 | -39,133 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 262,160 | 217,097 | -45,063 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 47,973 | 0 | -47,973 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 49,777 | 0 | -49,777 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 294,422 | 212,538 | -81,884 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 105,573 | 0 | -105,573 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 118,547 | 542 | -118,005 | 0.00 | 0.00 | -0.00 | sell |
| venBio Partners LLC | 1,148,975 | 648,507 | -500,468 | 1.87 | 1.29 | -0.58 | sell |
| CITADEL ADVISORS LLC | 798,397 | 0 | -798,397 | 0.00 | 0.00 | -0.00 | sell |