| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | 11,189,693 | 0 | 1.65 | 1.49 | -0.15 | hold |
| BlackRock, Inc. | 5,433,233 | 6,134,667 | +701,434 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 3,550,000 | 3,804,481 | +254,481 | 8.09 | 10.07 | +1.98 | buy |
| STATE STREET CORP | 2,464,017 | 3,004,899 | +540,882 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,535,724 | 2,412,825 | -122,899 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 54,200 | 2,352,927 | +2,298,727 | 0.00 | 0.05 | +0.05 | buy |
| Point72 Asset Management, L.P. | 1,156,140 | 1,993,837 | +837,697 | 0.03 | 0.05 | +0.02 | buy |
| TCG Crossover Management, LLC | 1,789,617 | 1,789,617 | 0 | 0.71 | 0.66 | -0.05 | hold |
| Alyeska Investment Group, L.P. | 1,601,089 | 1,647,140 | +46,051 | 0.06 | 0.07 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,597,650 | 1,507,360 | -90,290 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 116,099 | 1,207,250 | +1,091,151 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,146,724 | 1,204,150 | +57,426 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 352,177 | 1,200,737 | +848,560 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 443,397 | 1,110,889 | +667,492 | 0.09 | 0.20 | +0.11 | buy |
| D. E. Shaw & Co., Inc. | 98,395 | 1,096,509 | +998,114 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 602,013 | 952,675 | +350,662 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 801,646 | 910,460 | +108,814 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 703,940 | 836,966 | +133,026 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 809,914 | 809,914 | 0 | 0.70 | 0.75 | +0.05 | hold |
| Qube Research & Technologies Ltd | 197,145 | 702,057 | +504,912 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 604,000 | 532,321 | -71,679 | 0.02 | 0.02 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 983,600 | 524,700 | -458,900 | 0.30 | 0.15 | -0.15 | sell |
| MILLENNIUM MANAGEMENT LLC | 386,810 | 504,544 | +117,734 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 366,699 | 491,001 | +124,302 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 298,546 | 420,881 | +122,335 | 0.25 | 0.30 | +0.05 | buy |
| NORTHERN TRUST CORP | 362,180 | 398,366 | +36,186 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 251,740 | 391,991 | +140,251 | 0.00 | 0.00 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 376,496 | 376,496 | 0 | 0.44 | 0.32 | -0.13 | hold |
| Woodline Partners LP | 738,032 | 370,032 | -368,000 | 0.04 | 0.02 | -0.02 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 369,191 | +369,191 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 354,328 | 369,191 | +14,863 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 367,009 | 367,009 | 0 | 0.30 | 0.28 | -0.03 | hold |
| Jump Financial, LLC | 221,800 | 361,665 | +139,865 | 0.05 | 0.05 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 96,630 | 359,725 | +263,095 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 269,113 | +269,113 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 342,986 | 248,801 | -94,185 | 0.01 | 0.01 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,090,147 | 211,635 | -878,512 | 0.03 | 0.01 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 105,300 | 209,593 | +104,293 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 139,967 | 196,487 | +56,520 | 0.04 | 0.06 | +0.02 | buy |
| JPMORGAN CHASE & CO | 229,268 | 178,535 | -50,733 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 168,976 | 166,092 | -2,884 | 0.00 | 0.00 | -0.00 | sell |
| BML Capital Management, LLC | 154,961 | 154,961 | 0 | 1.39 | 1.36 | -0.03 | hold |
| UBS Group AG | 219,806 | 150,701 | -69,105 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 119,826 | 135,072 | +15,246 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 119,376 | 133,870 | +14,494 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 115,030 | +115,030 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 108,077 | +108,077 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 90,101 | 105,281 | +15,180 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 115,867 | 101,972 | -13,895 | 0.01 | 0.01 | -0.00 | sell |
| Rangeley Capital, LLC | 122,500 | 97,978 | -24,522 | 1.84 | 1.40 | -0.44 | sell |
| Nuveen, LLC | 97,120 | 97,120 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WINTON GROUP Ltd | 68,500 | 90,300 | +21,800 | 0.03 | 0.04 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,800 | 84,981 | +26,181 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 77,100 | 79,300 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 42,938 | 78,142 | +35,204 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 42,814 | 77,233 | +34,419 | 0.01 | 0.02 | +0.01 | buy |
| Quantinno Capital Management LP | 26,064 | 70,237 | +44,173 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 11,738 | 70,235 | +58,497 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 66,867 | 67,610 | +743 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 55,988 | 63,679 | +7,691 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 63,355 | +63,355 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 130,618 | 62,338 | -68,280 | 0.01 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,590 | 60,960 | +25,370 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 55,000 | 60,000 | +5,000 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 87,757 | 59,019 | -28,738 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 46,923 | 58,002 | +11,079 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 52,637 | 55,221 | +2,584 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 75,732 | 53,608 | -22,124 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 51,189 | 51,522 | +333 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 51,189 | 51,522 | +333 | 0.05 | 0.03 | -0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,001 | 50,932 | +13,931 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 8,432 | 48,774 | +40,342 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 24,880 | 48,726 | +23,846 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 49,383 | 48,376 | -1,007 | 0.19 | 0.17 | -0.02 | sell |
| GSA CAPITAL PARTNERS LLP | 50,351 | 48,139 | -2,212 | 0.04 | 0.05 | +0.00 | sell |
| AXQ CAPITAL, LP | 22,731 | 47,508 | +24,777 | 0.04 | 0.08 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 30,215 | 46,476 | +16,261 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 51,821 | 45,313 | -6,508 | 0.01 | 0.01 | +0.00 | sell |
| Creative Planning | 35,208 | 44,232 | +9,024 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 51,263 | 44,101 | -7,162 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 36,620 | 43,278 | +6,658 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 21,460 | 41,429 | +19,969 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 12,339 | 40,161 | +27,822 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 38,875 | 38,875 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jackson Creek Investment Advisors LLC | 0 | 34,719 | +34,719 | 0.00 | 0.17 | +0.17 | buy |
| MARSHALL WACE, LLP | 0 | 32,734 | +32,734 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 33,379 | 30,998 | -2,381 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 37,984 | 30,977 | -7,007 | 0.01 | 0.01 | -0.00 | sell |
| FNY Investment Advisers, LLC | 30,710 | 30,850 | +140 | 0.19 | 0.17 | -0.02 | buy |
| Hudson Bay Capital Management LP | 110,000 | 30,000 | -80,000 | 0.01 | 0.00 | -0.01 | sell |
| SG Americas Securities, LLC | 31,533 | 29,278 | -2,255 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 0 | 28,502 | +28,502 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 29,689 | 28,070 | -1,619 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 33,776 | 26,973 | -6,803 | 0.02 | 0.01 | -0.01 | sell |
| Entropy Technologies, LP | 10,701 | 26,795 | +16,094 | 0.01 | 0.02 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,364 | 26,137 | +773 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 26,031 | 26,031 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Lester Murray Antman dba SimplyRich | 24,315 | 24,315 | 0 | 0.09 | 0.09 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 17,821 | 24,130 | +6,309 | 0.07 | 0.09 | +0.02 | buy |