| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,165,652 | 9,165,652 | 0 | 1.54 | 4.39 | +2.85 | hold |
| FMR LLC | 4,671,213 | 7,749,009 | +3,077,796 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 3,317,927 | 4,275,553 | +957,626 | 0.71 | 2.96 | +2.24 | buy |
| BVF INC/IL | 4,579,818 | 2,919,818 | -1,660,000 | 1.23 | 3.02 | +1.79 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,355,475 | 2,775,672 | +1,420,197 | 0.03 | 0.20 | +0.17 | buy |
| CITADEL ADVISORS LLC | 3,120,205 | 2,350,238 | -769,967 | 0.03 | 0.09 | +0.05 | sell |
| JANUS HENDERSON GROUP PLC | 1,931,477 | 1,965,546 | +34,069 | 0.01 | 0.04 | +0.03 | buy |
| VANGUARD GROUP INC | 979,483 | 1,357,960 | +378,477 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.56 | +0.56 | buy |
| Cormorant Asset Management, LP | 0 | 750,000 | +750,000 | 0.00 | 1.24 | +1.24 | buy |
| LORD, ABBETT & CO. LLC | 0 | 542,373 | +542,373 | 0.00 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 408,190 | 467,547 | +59,357 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 347,585 | 399,467 | +51,882 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 384,245 | +384,245 | 0.00 | 0.51 | +0.51 | buy |
| GOLDMAN SACHS GROUP INC | 39,948 | 347,171 | +307,223 | 0.00 | 0.00 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 0 | 296,391 | +296,391 | 0.00 | 0.19 | +0.19 | buy |
| TWO SIGMA INVESTMENTS, LP | 44,108 | 224,720 | +180,612 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 204,002 | 201,983 | -2,019 | 0.00 | 0.00 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 197,490 | 193,046 | -4,444 | 0.01 | 0.05 | +0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 191,055 | +191,055 | 0.00 | 0.07 | +0.07 | buy |
| Samsara BioCapital, LLC | 360,414 | 180,207 | -180,207 | 0.60 | 1.05 | +0.45 | sell |
| Soleus Capital Management, L.P. | 0 | 157,800 | +157,800 | 0.00 | 0.52 | +0.52 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 152,721 | +152,721 | 0.00 | 0.05 | +0.05 | buy |
| Logos Global Management LP | 0 | 150,000 | +150,000 | 0.00 | 0.59 | +0.59 | buy |
| STEMPOINT CAPITAL LP | 0 | 121,642 | +121,642 | 0.00 | 1.22 | +1.22 | buy |
| MORGAN STANLEY | 0 | 121,231 | +121,231 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 104,500 | +104,500 | 0.00 | 0.37 | +0.37 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 92,899 | +92,899 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 23,600 | 83,000 | +59,400 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 0 | 80,005 | +80,005 | 0.00 | 0.02 | +0.02 | buy |
| Atika Capital Management LLC | 0 | 64,500 | +64,500 | 0.00 | 0.27 | +0.27 | buy |
| MACQUARIE GROUP LTD | 0 | 60,000 | +60,000 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 55,973 | +55,973 | 0.00 | 0.33 | +0.33 | buy |
| D. E. Shaw & Co., Inc. | 0 | 54,638 | +54,638 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 52,300 | +52,300 | 0.00 | 0.04 | +0.04 | buy |
| Artal Group S.A. | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,141 | 49,258 | +3,117 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 52,746 | 48,687 | -4,059 | 0.00 | 0.00 | +0.00 | sell |
| Artia Global Partners LP | 0 | 47,949 | +47,949 | 0.00 | 0.44 | +0.44 | buy |
| Squarepoint Ops LLC | 61,168 | 43,151 | -18,017 | 0.00 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 3,827 | 41,572 | +37,745 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 58,804 | 40,919 | -17,885 | 0.01 | 0.02 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 40,653 | +40,653 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 40,000 | +40,000 | 0.00 | 0.04 | +0.04 | buy |
| Ovata Capital Management Ltd | 0 | 40,000 | +40,000 | 0.00 | 0.78 | +0.78 | buy |
| Swiss National Bank | 31,800 | 31,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 31,595 | +31,595 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 31,323 | +31,323 | 0.00 | 0.10 | +0.10 | buy |
| Woodline Partners LP | 0 | 29,848 | +29,848 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 11,443 | 27,055 | +15,612 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,085 | 26,923 | +838 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,121 | 23,990 | +8,869 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 23,617 | +23,617 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 17,370 | 23,550 | +6,180 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 43,801 | 23,541 | -20,260 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 0 | 22,204 | +22,204 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 60,933 | 21,431 | -39,502 | 0.00 | 0.00 | -0.00 | sell |
| Capula Management Ltd | 0 | 21,352 | +21,352 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 20,132 | +20,132 | 0.00 | 0.00 | +0.00 | buy |
| Ratan Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.40 | +0.40 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 19,596 | +19,596 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 17,736 | 19,343 | +1,607 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,192 | 16,263 | -929 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 0 | 16,183 | +16,183 | 0.00 | 0.05 | +0.05 | buy |
| Legal & General Group Plc | 9,881 | 16,107 | +6,226 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 15,691 | +15,691 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 15,597 | +15,597 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 47,722 | 15,500 | -32,222 | 0.00 | 0.00 | -0.00 | sell |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 0 | 15,000 | +15,000 | 0.00 | 0.08 | +0.08 | buy |
| Scientech Research LLC | 0 | 14,174 | +14,174 | 0.00 | 0.28 | +0.28 | buy |
| ADAR1 Capital Management, LLC | 0 | 14,000 | +14,000 | 0.00 | 0.14 | +0.14 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 11,591 | +11,591 | 0.00 | 0.01 | +0.01 | buy |
| Orion Porfolio Solutions, LLC | 0 | 10,960 | +10,960 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,343 | 9,743 | +4,400 | 0.01 | 0.05 | +0.04 | buy |
| SEI INVESTMENTS CO | 0 | 9,134 | +9,134 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,614 | 9,061 | -1,553 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 8,695 | +8,695 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 8,596 | 8,524 | -72 | 0.00 | 0.00 | +0.00 | sell |
| Chicago Partners Investment Group LLC | 0 | 8,464 | +8,464 | 0.00 | 0.02 | +0.02 | buy |
| Lester Murray Antman dba SimplyRich | 0 | 7,964 | +7,964 | 0.00 | 0.10 | +0.10 | buy |
| Invesco Ltd. | 0 | 7,807 | +7,807 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 14,204 | 7,544 | -6,660 | 0.00 | 0.01 | +0.00 | sell |
| BAILARD, INC. | 0 | 7,400 | +7,400 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,050 | 7,239 | +2,189 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 7,184 | +7,184 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,909 | +6,909 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 12,816 | 6,892 | -5,924 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 6,808 | +6,808 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,973 | 6,725 | -248 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 0 | 6,655 | +6,655 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 6,415 | +6,415 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 26,264 | 6,349 | -19,915 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 6,153 | +6,153 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,288 | 6,100 | +812 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 71,856 | 5,784 | -66,072 | 0.00 | 0.00 | -0.00 | sell |
| Belvedere Trading LLC | 0 | 5,637 | +5,637 | 0.00 | 0.02 | +0.02 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,710 | 2,733 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,706 | 1,706 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AlphaQuest LLC | 0 | 1,423 | +1,423 | 0.00 | 0.01 | +0.01 | buy |