| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,355,475 | 2,775,672 | +1,420,197 | 0.03 | 0.20 | +0.17 | buy |
| ORBIMED ADVISORS LLC | 3,317,927 | 4,275,553 | +957,626 | 0.71 | 2.96 | +2.24 | buy |
| JANUS HENDERSON GROUP PLC | 1,931,477 | 1,965,546 | +34,069 | 0.01 | 0.04 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,343 | 9,743 | +4,400 | 0.01 | 0.05 | +0.04 | buy |
| Fortitude Family Office, LLC | 237 | 207 | -30 | 0.00 | 0.01 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 197,490 | 193,046 | -4,444 | 0.01 | 0.04 | +0.03 | sell |
| ZACKS INVESTMENT MANAGEMENT | 58,804 | 40,919 | -17,885 | 0.01 | 0.02 | +0.01 | sell |
| Samsara BioCapital, LLC | 360,414 | 180,207 | -180,207 | 0.60 | 1.05 | +0.45 | sell |
| BVF INC/IL | 4,579,818 | 2,919,818 | -1,660,000 | 1.23 | 3.02 | +1.79 | sell |