| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,562,402 | 4,598,092 | +1,035,690 | 0.10 | 0.07 | 0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,365,652 | 11,189,693 | +824,041 | 7.39 | 5.05 | -2.34 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,061,750 | 3,654,574 | +592,824 | 0.29 | 0.18 | -0.10 | buy |
| Logos Global Management LP | 1,250,000 | 1,650,000 | +400,000 | 7.83 | 7.92 | +0.09 | buy |
| Prosight Management, LP | 329,768 | 689,901 | +360,133 | 4.88 | 6.12 | +1.24 | buy |
| First Light Asset Management, LLC | 313,782 | 658,824 | +345,042 | 1.61 | 2.03 | +0.42 | buy |
| MPM BioImpact LLC | 230,000 | 567,193 | +337,193 | 1.75 | 2.63 | +0.88 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,109,978 | 1,392,826 | +282,848 | 0.01 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 145,876 | 342,062 | +196,186 | 1.96 | 2.95 | +0.99 | buy |
| Aberdeen Group plc | 64,072 | 224,788 | +160,716 | 0.01 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 817,895 | 970,412 | +152,517 | 1.21 | 0.93 | -0.28 | buy |
| ADAR1 Capital Management, LLC | 31,509 | 153,767 | +122,258 | 0.35 | 0.80 | +0.45 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 150,000 | +100,000 | 0.18 | 0.22 | +0.05 | buy |
| Alyeska Investment Group, L.P. | 344,916 | 408,678 | +63,762 | 0.07 | 0.04 | -0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 68,333 | 125,840 | +57,507 | 0.66 | 0.78 | +0.12 | buy |
| Ikarian Capital, LLC | 74,691 | 129,691 | +55,000 | 1.14 | 1.14 | -0.00 | buy |
| Springhill Fund Asset Management (HK) Co Ltd | 29,600 | 78,500 | +48,900 | 2.57 | 10.16 | +7.58 | buy |
| First Turn Management, LLC | 383,602 | 430,163 | +46,561 | 3.68 | 2.34 | -1.34 | buy |
| NEOS Investment Management LLC | 5,223 | 45,937 | +40,714 | 0.01 | 0.02 | +0.02 | buy |
| TEMA ETFS LLC | 5,223 | 45,937 | +40,714 | 0.12 | 0.37 | +0.25 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 156,874 | 192,372 | +35,498 | 0.01 | 0.01 | -0.00 | buy |
| Quinn Opportunity Partners LLC | 20,000 | 51,893 | +31,893 | 0.07 | 0.10 | +0.02 | buy |
| Magnetar Financial LLC | 13,498 | 41,055 | +27,557 | 0.02 | 0.01 | -0.00 | buy |
| ALGERT GLOBAL LLC | 64,961 | 40,660 | +24,301 | 0.08 | 0.03 | 0.00 | sell |
| Atle Fund Management AB | 39,573 | 46,808 | +7,235 | 0.99 | 0.56 | -0.43 | buy |
| HighVista Strategies LLC | 69,715 | 74,556 | +4,841 | 1.39 | 0.78 | -0.61 | buy |
| Rafferty Asset Management, LLC | 52,168 | 56,279 | +4,111 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 64,568 | 68,644 | +4,076 | 0.17 | 0.09 | -0.09 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 12,713 | 16,601 | +3,888 | 0.02 | 0.01 | -0.00 | buy |
| FNY Investment Advisers, LLC | 35 | 2,460 | +2,425 | 0.00 | 0.04 | +0.04 | buy |
| DnB Asset Management AS | 5,778 | 7,765 | +1,987 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 10,206 | 11,726 | +1,520 | 0.02 | 0.01 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 11,128 | 11,855 | +727 | 0.06 | 0.03 | -0.03 | buy |
| Avanza Fonder AB | 2,605 | 3,049 | +444 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,102 | 1,343 | +241 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 10 | 66 | +56 | 0.00 | 0.00 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 29 | 78 | +49 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 38,173 | 38,122 | -51 | 0.02 | 0.01 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 52,379 | 50,106 | -2,273 | 0.03 | 0.02 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 90,292 | 81,292 | -9,000 | 4.14 | 1.98 | -2.17 | sell |
| TD ASSET MANAGEMENT INC | 78,836 | 65,636 | -13,200 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 50,958 | 37,562 | -13,396 | 0.24 | 0.10 | -0.14 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 205,167 | 177,820 | -27,347 | 100.00 | 3.37 | -96.63 | sell |
| Rhenman & Partners Asset Management AB | 170,000 | 141,627 | -28,373 | 0.94 | 0.44 | -0.50 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 429,392 | 376,496 | -52,896 | 2.78 | 2.10 | -0.68 | sell |
| READYSTATE ASSET MANAGEMENT LP | 339,639 | 276,560 | -63,079 | 0.77 | 0.37 | -0.39 | sell |
| Cormorant Asset Management, LP | 2,100,000 | 2,000,000 | -100,000 | 6.17 | 4.06 | -2.11 | sell |
| Ratan Capital Management LP | 179,307 | 76,800 | -102,507 | 1.47 | 0.67 | -0.80 | sell |
| Artia Global Partners LP | 162,976 | 38,100 | -124,876 | 3.52 | 0.30 | -3.22 | sell |
| Paradigm Biocapital Advisors LP | 3,515,986 | 3,329,909 | -186,077 | 6.55 | 4.14 | -2.41 | sell |
| Woodline Partners LP | 1,852,187 | 1,457,095 | -395,092 | 0.67 | 0.26 | -0.42 | sell |
| Avidity Partners Management LP | 741,900 | 258,000 | -483,900 | 3.96 | 1.44 | -2.52 | sell |
| LORD, ABBETT & CO. LLC | 1,267,803 | 667,881 | -599,922 | 0.21 | 0.06 | -0.15 | sell |