| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,562,402 | 4,598,092 | +1,035,690 | 0.10 | 0.07 | -0.02 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,365,652 | 11,189,693 | +824,041 | 7.39 | 5.05 | -2.34 | buy |
| FRANKLIN RESOURCES INC | 497,287 | 1,186,479 | +689,192 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,061,750 | 3,654,574 | +592,824 | 0.29 | 0.18 | -0.10 | buy |
| Logos Global Management LP | 1,250,000 | 1,650,000 | +400,000 | 7.83 | 7.92 | +0.09 | buy |
| Prosight Management, LP | 329,768 | 689,901 | +360,133 | 4.95 | 6.12 | +1.17 | buy |
| First Light Asset Management, LLC | 313,782 | 658,824 | +345,042 | 1.61 | 2.03 | +0.42 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,471 | 368,935 | +339,464 | 0.00 | 0.02 | +0.01 | buy |
| MPM BioImpact LLC | 230,000 | 567,193 | +337,193 | 1.75 | 2.63 | +0.88 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,109,978 | 1,392,826 | +282,848 | 0.01 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 384,797 | 656,605 | +271,808 | 0.02 | 0.02 | -0.00 | buy |
| UBS Group AG | 225,090 | 488,480 | +263,390 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 14,906 | 261,262 | +246,356 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,669,941 | 8,884,072 | +214,131 | 0.03 | 0.02 | -0.01 | buy |
| STEMPOINT CAPITAL LP | 145,876 | 342,062 | +196,186 | 1.96 | 2.95 | +0.99 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 174,350 | +174,350 | 0.00 | 0.04 | +0.04 | buy |
| Aberdeen Group plc | 64,072 | 224,788 | +160,716 | 0.01 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 1,011 | 153,848 | +152,837 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 817,895 | 970,412 | +152,517 | 1.22 | 0.93 | -0.29 | buy |
| Ensign Peak Advisors, Inc | 142,300 | 294,750 | +152,450 | 0.01 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 2,725,813 | 2,872,959 | +147,146 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 2,136,332 | 2,278,660 | +142,328 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 31,509 | 153,767 | +122,258 | 0.35 | 0.80 | +0.45 | buy |
| STATE STREET CORP | 1,267,949 | 1,371,497 | +103,548 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 65,858 | 168,972 | +103,114 | 0.04 | 0.05 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 150,000 | +100,000 | 0.18 | 0.22 | +0.05 | buy |
| Jump Financial, LLC | 0 | 94,030 | +94,030 | 0.00 | 0.04 | +0.04 | buy |
| Hudson Bay Capital Management LP | 30,000 | 110,000 | +80,000 | 0.01 | 0.02 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 77,437 | +77,437 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 229,390 | 303,194 | +73,804 | 0.02 | 0.01 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 714,956 | 780,909 | +65,953 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 217,831 | 282,427 | +64,596 | 0.00 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 344,916 | 408,678 | +63,762 | 0.07 | 0.04 | -0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 68,333 | 125,840 | +57,507 | 0.68 | 0.84 | +0.16 | buy |
| Aquatic Capital Management LLC | 6,156 | 62,469 | +56,313 | 0.01 | 0.04 | +0.03 | buy |
| Ikarian Capital, LLC | 74,691 | 129,691 | +55,000 | 1.14 | 1.14 | -0.00 | buy |
| Springhill Fund Asset Management (HK) Co Ltd | 29,600 | 78,500 | +48,900 | 2.57 | 10.16 | +7.58 | buy |
| First Turn Management, LLC | 383,602 | 430,163 | +46,561 | 3.68 | 2.34 | -1.34 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 44,672 | +44,672 | 0.00 | 0.06 | +0.06 | buy |
| NEOS Investment Management LLC | 5,223 | 45,937 | +40,714 | 0.01 | 0.02 | +0.02 | buy |
| TEMA ETFS LLC | 5,223 | 45,937 | +40,714 | 0.12 | 0.37 | +0.25 | buy |
| Cubist Systematic Strategies, LLC | 40,349 | 75,860 | +35,511 | 0.04 | 0.03 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 156,874 | 192,372 | +35,498 | 0.01 | 0.01 | -0.00 | buy |
| Quinn Opportunity Partners LLC | 20,000 | 51,893 | +31,893 | 0.08 | 0.10 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,640 | 59,376 | +31,736 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 28,631 | +28,631 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 27,964 | +27,964 | 0.00 | 0.01 | +0.01 | buy |
| Magnetar Financial LLC | 13,498 | 41,055 | +27,557 | 0.02 | 0.01 | -0.00 | buy |
| Erste Asset Management GmbH | 0 | 27,000 | +27,000 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 242,409 | 265,651 | +23,242 | 0.01 | 0.01 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 165,737 | 186,394 | +20,657 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 17,833 | +17,833 | 0.00 | 0.03 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 26,897 | 44,658 | +17,761 | 0.04 | 0.04 | -0.00 | buy |
| Squarepoint Ops LLC | 41,176 | 57,448 | +16,272 | 0.01 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 15,040 | +15,040 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 5,352 | 18,491 | +13,139 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 0 | 11,380 | +11,380 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 8,270 | 18,884 | +10,614 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 78,859 | 89,370 | +10,511 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,733 | 50,965 | +10,232 | 0.01 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 4,972 | 12,987 | +8,015 | 0.01 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 34,540 | 42,298 | +7,758 | 0.00 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 39,573 | 46,808 | +7,235 | 0.99 | 0.56 | -0.43 | buy |
| Point72 (DIFC) Ltd | 10,907 | 17,663 | +6,756 | 0.05 | 0.05 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 93,029 | 99,691 | +6,662 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,512 | 68,745 | +5,233 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 69,715 | 74,556 | +4,841 | 1.39 | 0.78 | -0.61 | buy |
| RHUMBLINE ADVISERS | 38,153 | 42,650 | +4,497 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 52,168 | 56,279 | +4,111 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 64,568 | 68,644 | +4,076 | 0.17 | 0.09 | -0.09 | buy |
| AQR CAPITAL MANAGEMENT LLC | 5,658 | 9,717 | +4,059 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 12,713 | 16,601 | +3,888 | 0.02 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,010 | 21,403 | +3,393 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 3,187 | +3,187 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 5,865 | 9,033 | +3,168 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 2,668 | +2,668 | 0.00 | 0.02 | +0.02 | buy |
| KBC Group NV | 0 | 2,461 | +2,461 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 35 | 2,460 | +2,425 | 0.00 | 0.04 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 13,251 | 15,345 | +2,094 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 5,778 | 7,765 | +1,987 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 69 | 1,727 | +1,658 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 13,940 | 15,495 | +1,555 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 10,206 | 11,726 | +1,520 | 0.02 | 0.01 | -0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,637 | 7,125 | +1,488 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 17,298 | 18,663 | +1,365 | 0.01 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,177 | 6,994 | +817 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,128 | 11,855 | +727 | 0.06 | 0.03 | -0.03 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 3,357 | 4,043 | +686 | 0.00 | 0.00 | -0.00 | buy |
| ANTIPODES PARTNERS Ltd | 0 | 632 | +632 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 273,135 | 273,643 | +508 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,964 | 16,435 | +471 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,747 | 3,200 | +453 | 0.00 | 0.00 | -0.00 | buy |
| Avanza Fonder AB | 2,605 | 3,049 | +444 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 15 | 351 | +336 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,102 | 1,343 | +241 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,749 | 1,947 | +198 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 171 | +171 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 118 | 258 | +140 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 970 | 1,090 | +120 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 107 | +107 | 0.00 | 0.00 | +0.00 | buy |