| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | 11,189,693 | 0 | 1.58 | 1.65 | +0.07 | hold |
| BlackRock, Inc. | 4,080,200 | 5,433,233 | +1,353,033 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 5,350,453 | 4,196,409 | -1,154,044 | 0.03 | 0.03 | -0.01 | sell |
| Prosight Management, LP | 2,392,523 | 3,550,000 | +1,157,477 | 6.82 | 8.09 | +1.27 | buy |
| FMR LLC | 3,512,384 | 2,535,724 | -976,660 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 3,853,951 | 2,464,017 | -1,389,934 | 0.00 | 0.00 | -0.00 | sell |
| TCG Crossover Management, LLC | 1,789,617 | 1,789,617 | 0 | 0.82 | 0.71 | -0.11 | hold |
| Alyeska Investment Group, L.P. | 1,301,089 | 1,601,089 | +300,000 | 0.05 | 0.06 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,610,186 | 1,597,650 | -12,536 | 0.00 | 0.00 | +0.00 | sell |
| Deep Track Capital, LP | 89,589 | 1,187,290 | +1,097,701 | 0.03 | 0.34 | +0.31 | buy |
| Point72 Asset Management, L.P. | 961,819 | 1,156,140 | +194,321 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,113,582 | 1,146,724 | +33,142 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 885,551 | 1,090,147 | +204,596 | 0.02 | 0.03 | +0.01 | buy |
| Logos Global Management LP | 1,000,000 | 1,000,000 | 0 | 0.92 | 0.72 | -0.20 | hold |
| ORBIMED ADVISORS LLC | 1,954,426 | 983,600 | -970,826 | 0.55 | 0.30 | -0.25 | sell |
| Nantahala Capital Management, LLC | 0 | 809,914 | +809,914 | 0.00 | 0.70 | +0.70 | buy |
| BANK OF AMERICA CORP /DE/ | 738,330 | 801,646 | +63,316 | 0.00 | 0.00 | +0.00 | buy |
| Irenic Capital Management LP | 0 | 765,804 | +765,804 | 0.00 | 0.97 | +0.97 | buy |
| Woodline Partners LP | 1,027,221 | 738,032 | -289,189 | 0.05 | 0.04 | -0.02 | sell |
| MORGAN STANLEY | 618,385 | 703,940 | +85,555 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 390,952 | 604,000 | +213,048 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,073,656 | 602,013 | -471,643 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 500,000 | +500,000 | 0.00 | 0.35 | +0.35 | buy |
| ALGERT GLOBAL LLC | 183,367 | 443,397 | +260,030 | 0.04 | 0.09 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 289,808 | 386,810 | +97,002 | 0.00 | 0.00 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 376,496 | 376,496 | 0 | 0.46 | 0.44 | -0.02 | hold |
| Rock Springs Capital Management LP | 358,798 | 367,009 | +8,211 | 0.25 | 0.30 | +0.05 | buy |
| HRT FINANCIAL LP | 63,544 | 366,699 | +303,155 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 340,406 | 362,180 | +21,774 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 390,506 | 354,328 | -36,178 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,104,144 | 352,177 | -751,967 | 0.01 | 0.00 | -0.01 | sell |
| Man Group plc | 64,512 | 342,986 | +278,474 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 245,452 | 298,546 | +53,094 | 0.25 | 0.25 | -0.00 | buy |
| JANE STREET GROUP, LLC | 540,233 | 251,740 | -288,493 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 170,509 | 229,268 | +58,759 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 96,684 | 221,800 | +125,116 | 0.02 | 0.05 | +0.03 | buy |
| UBS Group AG | 590,060 | 219,806 | -370,254 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 216,005 | 197,145 | -18,860 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 267,051 | 195,160 | -71,891 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 0 | 168,976 | +168,976 | 0.00 | 0.00 | +0.00 | buy |
| BML Capital Management, LLC | 0 | 154,961 | +154,961 | 0.00 | 1.39 | +1.39 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 139,967 | +139,967 | 0.00 | 0.04 | +0.04 | buy |
| Walleye Capital LLC | 323,017 | 130,618 | -192,399 | 0.03 | 0.01 | -0.01 | sell |
| Rangeley Capital, LLC | 25,414 | 122,500 | +97,086 | 0.30 | 1.84 | +1.54 | buy |
| Bank of New York Mellon Corp | 122,066 | 119,826 | -2,240 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 119,376 | +119,376 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,237 | 119,055 | +83,818 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 471,009 | 116,099 | -354,910 | 0.01 | 0.00 | -0.01 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 115,867 | +115,867 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 161,548 | 114,572 | -46,976 | 0.02 | 0.02 | -0.01 | sell |
| Hudson Bay Capital Management LP | 110,000 | 110,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| READYSTATE ASSET MANAGEMENT LP | 885,895 | 109,425 | -776,470 | 0.54 | 0.09 | -0.45 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,951 | 105,300 | +101,349 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 32,707 | 98,395 | +65,688 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 96,416 | 97,120 | +704 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 224,294 | 96,630 | -127,664 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 52,421 | 93,974 | +41,553 | 0.02 | 0.04 | +0.02 | buy |
| Weiss Asset Management LP | 0 | 93,144 | +93,144 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 385,301 | 90,101 | -295,200 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,498 | 87,757 | +12,259 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 77,100 | 77,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 175,248 | 75,732 | -99,516 | 0.01 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 31,800 | 68,500 | +36,700 | 0.02 | 0.03 | +0.02 | buy |
| CONGRESS ASSET MANAGEMENT CO | 57,342 | 66,867 | +9,525 | 0.01 | 0.01 | +0.00 | buy |
| Headlands Technologies LLC | 56,497 | 61,633 | +5,136 | 0.07 | 0.10 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 744,466 | 58,800 | -685,666 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 221,233 | 55,988 | -165,245 | 0.00 | 0.00 | -0.00 | sell |
| Raiffeisen Bank International AG | 46,000 | 55,000 | +9,000 | 0.01 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 11,898 | 54,200 | +42,302 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 52,361 | 52,637 | +276 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 13,147 | 51,821 | +38,674 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 51,263 | +51,263 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 51,189 | +51,189 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 37,092 | 51,189 | +14,097 | 0.04 | 0.05 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 50,351 | +50,351 | 0.00 | 0.04 | +0.04 | buy |
| HRT FINANCIAL LP | 0 | 50,200 | +50,200 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 41,443 | 49,383 | +7,940 | 0.15 | 0.19 | +0.04 | buy |
| Invesco Ltd. | 28,322 | 46,923 | +18,601 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 21,062 | 42,938 | +21,876 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 161,427 | 42,814 | -118,613 | 0.06 | 0.01 | -0.05 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 38,875 | 38,875 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 11,240 | 37,984 | +26,744 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,320 | 37,001 | -319 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 32,170 | 36,620 | +4,450 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 35,590 | 35,590 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 0 | 35,208 | +35,208 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 64,022 | 33,776 | -30,246 | 0.03 | 0.02 | -0.01 | sell |
| Legal & General Group Plc | 43,467 | 33,379 | -10,088 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 79,817 | 31,533 | -48,284 | 0.00 | 0.00 | -0.00 | sell |
| FNY Investment Advisers, LLC | 10,300 | 30,710 | +20,410 | 0.04 | 0.19 | +0.15 | buy |
| AMERICAN CENTURY COMPANIES INC | 27,691 | 30,215 | +2,524 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 79,158 | 29,689 | -49,469 | 0.01 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 24,218 | 26,064 | +1,846 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 23,876 | 26,031 | +2,155 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,148 | 25,364 | -4,784 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 47,919 | 24,880 | -23,039 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 14,757 | 24,639 | +9,882 | 0.00 | 0.00 | -0.00 | buy |
| Lester Murray Antman dba SimplyRich | 24,315 | 24,315 | 0 | 0.09 | 0.09 | -0.00 | hold |
| Quadrature Capital Ltd | 33,002 | 22,889 | -10,113 | 0.00 | 0.00 | -0.00 | sell |