| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 1,564,452 | +1,564,452 | 0.00 | 2.51 | +2.51 | buy |
| EcoR1 Capital, LLC | 0 | 1,469,818 | +1,469,818 | 0.00 | 1.88 | +1.88 | buy |
| STATE STREET CORP | 399,467 | 1,401,234 | +1,001,767 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 725,000 | +725,000 | 0.00 | 2.26 | +2.26 | buy |
| Logos Global Management LP | 150,000 | 750,000 | +600,000 | 0.59 | 3.62 | +3.03 | buy |
| Avidity Partners Management LP | 384,245 | 840,219 | +455,974 | 0.51 | 1.50 | +0.98 | buy |
| Cormorant Asset Management, LP | 750,000 | 1,050,000 | +300,000 | 1.24 | 2.56 | +1.31 | buy |
| Woodline Partners LP | 29,848 | 300,825 | +270,977 | 0.01 | 0.12 | +0.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,596 | 252,358 | +232,762 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,357,960 | 1,561,758 | +203,798 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 542,373 | 702,607 | +160,234 | 0.07 | 0.10 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 467,547 | 624,104 | +156,557 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 50,000 | 203,000 | +153,000 | 0.05 | 0.22 | +0.17 | buy |
| Point72 Asset Management, L.P. | 0 | 136,430 | +136,430 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 0 | 133,000 | +133,000 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 23,541 | 119,395 | +95,854 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 152,721 | 242,531 | +89,810 | 0.05 | 0.08 | +0.03 | buy |
| Ratan Capital Management LP | 20,000 | 105,757 | +85,757 | 0.40 | 1.36 | +0.95 | buy |
| Rafferty Asset Management, LLC | 0 | 77,246 | +77,246 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 48,687 | 115,027 | +66,340 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 6,415 | 67,487 | +61,072 | 0.00 | 0.03 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 55,212 | +55,212 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 54,638 | 97,823 | +43,185 | 0.00 | 0.01 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 40,000 | +40,000 | 0.00 | 0.47 | +0.47 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 35,181 | +35,181 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 34,664 | +34,664 | 0.00 | 0.01 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 33,516 | +33,516 | 0.00 | 0.03 | +0.03 | buy |
| Candriam S.C.A. | 80,005 | 112,004 | +31,999 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 22,204 | 50,868 | +28,664 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,749,009 | 7,777,600 | +28,591 | 0.02 | 0.02 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 296,391 | 324,703 | +28,312 | 0.19 | 0.23 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,258 | 77,516 | +28,258 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 24,519 | +24,519 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 23,332 | +23,332 | 0.00 | 0.36 | +0.36 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 8,695 | 30,178 | +21,483 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 40,653 | 60,578 | +19,925 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 19,800 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 19,500 | +19,500 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,153 | 25,624 | +19,471 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 20,132 | 39,566 | +19,434 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 7,184 | 24,048 | +16,864 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 60,000 | 76,601 | +16,601 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 14,399 | +14,399 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 14,274 | +14,274 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 15,500 | 29,178 | +13,678 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 31,595 | 43,934 | +12,339 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 12,220 | +12,220 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 11,541 | +11,541 | 0.00 | 0.00 | +0.00 | buy |
| Parkwood LLC | 0 | 11,390 | +11,390 | 0.00 | 0.06 | +0.06 | buy |
| RHUMBLINE ADVISERS | 26,923 | 38,008 | +11,085 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 10,142 | +10,142 | 0.00 | 0.07 | +0.07 | buy |
| Qube Research & Technologies Ltd | 0 | 10,034 | +10,034 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 9,980 | +9,980 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 0 | 9,723 | +9,723 | 0.00 | 0.02 | +0.02 | buy |
| HARVEST MANAGEMENT LLC | 0 | 9,700 | +9,700 | 0.00 | 0.33 | +0.33 | buy |
| Allianz Asset Management GmbH | 0 | 9,500 | +9,500 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 9,409 | +9,409 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 31,800 | 40,700 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 15,597 | 24,019 | +8,422 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 7,890 | +7,890 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 7,598 | +7,598 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 9,061 | 16,349 | +7,288 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 7,023 | +7,023 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 23,990 | 30,742 | +6,752 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 193,046 | 199,384 | +6,338 | 0.05 | 0.05 | +0.00 | buy |
| Arizona State Retirement System | 0 | 5,784 | +5,784 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,725 | 12,424 | +5,699 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 23,550 | 29,240 | +5,690 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 5,647 | +5,647 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 5,600 | +5,600 | 0.00 | 0.03 | +0.03 | buy |
| J. Goldman & Co LP | 0 | 5,400 | +5,400 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 0 | 5,273 | +5,273 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 16,107 | 21,285 | +5,178 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 5,125 | +5,125 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 4,858 | +4,858 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,263 | 20,738 | +4,475 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,423 | 5,795 | +4,372 | 0.01 | 0.03 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,239 | 11,546 | +4,307 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 3,609 | +3,609 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,100 | 9,007 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 15,691 | 18,100 | +2,409 | 0.02 | 0.02 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 104,500 | 106,847 | +2,347 | 0.37 | 0.43 | +0.06 | buy |
| VIRTUS ADVISERS, LLC | 0 | 2,137 | +2,137 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 7,807 | 9,653 | +1,846 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 1,649 | +1,649 | 0.00 | 0.03 | +0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,548 | +1,548 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,259 | 2,580 | +1,321 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 1,103 | +1,103 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,706 | 2,747 | +1,041 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 11 | 1,029 | +1,018 | 0.00 | 0.00 | +0.00 | buy |
| Plato Investment Management Ltd | 0 | 999 | +999 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 700 | +700 | 0.00 | 0.01 | +0.01 | buy |
| FNY Investment Advisers, LLC | 0 | 650 | +650 | 0.00 | 0.02 | +0.02 | buy |
| Pacer Advisors, Inc. | 0 | 439 | +439 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 381 | +381 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 602 | 970 | +368 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 5,637 | 5,857 | +220 | 0.02 | 0.01 | -0.00 | buy |
| US BANCORP \DE\ | 14 | 209 | +195 | 0.00 | 0.00 | +0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 0 | 169 | +169 | 0.00 | 0.00 | +0.00 | buy |