| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,165,652 | 9,165,652 | 0 | 4.39 | 5.08 | +0.69 | hold |
| FMR LLC | 7,749,009 | 7,777,600 | +28,591 | 0.02 | 0.02 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 4,275,553 | 2,979,828 | -1,295,725 | 2.96 | 2.48 | -0.47 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,775,672 | 2,327,896 | -447,776 | 0.20 | 0.18 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 1,965,546 | 1,801,843 | -163,703 | 0.04 | 0.04 | +0.00 | sell |
| Paradigm Biocapital Advisors LP | 0 | 1,564,452 | +1,564,452 | 0.00 | 2.51 | +2.51 | buy |
| VANGUARD GROUP INC | 1,357,960 | 1,561,758 | +203,798 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,350,238 | 1,557,116 | -793,122 | 0.09 | 0.06 | -0.02 | sell |
| EcoR1 Capital, LLC | 0 | 1,469,818 | +1,469,818 | 0.00 | 1.88 | +1.88 | buy |
| STATE STREET CORP | 399,467 | 1,401,234 | +1,001,767 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 750,000 | 1,050,000 | +300,000 | 1.24 | 2.56 | +1.31 | buy |
| Avidity Partners Management LP | 384,245 | 840,219 | +455,974 | 0.51 | 1.50 | +0.98 | buy |
| Logos Global Management LP | 150,000 | 750,000 | +600,000 | 0.59 | 3.62 | +3.03 | buy |
| Vestal Point Capital, LP | 0 | 725,000 | +725,000 | 0.00 | 2.26 | +2.26 | buy |
| LORD, ABBETT & CO. LLC | 542,373 | 702,607 | +160,234 | 0.07 | 0.10 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 467,547 | 624,104 | +156,557 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,919,818 | 441,528 | -2,478,290 | 3.02 | 0.52 | -2.50 | sell |
| GOLDMAN SACHS GROUP INC | 347,171 | 344,672 | -2,499 | 0.00 | 0.00 | +0.00 | sell |
| SAMLYN CAPITAL, LLC | 296,391 | 324,703 | +28,312 | 0.19 | 0.23 | +0.04 | buy |
| Woodline Partners LP | 29,848 | 300,825 | +270,977 | 0.01 | 0.12 | +0.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,596 | 252,358 | +232,762 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 152,721 | 242,531 | +89,810 | 0.05 | 0.08 | +0.03 | buy |
| Artal Group S.A. | 50,000 | 203,000 | +153,000 | 0.05 | 0.22 | +0.17 | buy |
| Alyeska Investment Group, L.P. | 193,046 | 199,384 | +6,338 | 0.05 | 0.05 | +0.00 | buy |
| NORTHERN TRUST CORP | 201,983 | 194,373 | -7,610 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 136,430 | +136,430 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 0 | 133,000 | +133,000 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 23,541 | 119,395 | +95,854 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 48,687 | 115,027 | +66,340 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 80,005 | 112,004 | +31,999 | 0.02 | 0.03 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 104,500 | 106,847 | +2,347 | 0.37 | 0.43 | +0.06 | buy |
| Ratan Capital Management LP | 20,000 | 105,757 | +85,757 | 0.40 | 1.36 | +0.95 | buy |
| TWO SIGMA INVESTMENTS, LP | 224,720 | 103,601 | -121,119 | 0.02 | 0.01 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 54,638 | 97,823 | +43,185 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 121,642 | 92,949 | -28,693 | 1.22 | 1.15 | -0.08 | sell |
| MORGAN STANLEY | 121,231 | 81,798 | -39,433 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,258 | 77,516 | +28,258 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 77,246 | +77,246 | 0.00 | 0.01 | +0.01 | buy |
| MACQUARIE GROUP LTD | 60,000 | 76,601 | +16,601 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 6,415 | 67,487 | +61,072 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 40,653 | 60,578 | +19,925 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 55,973 | 55,618 | -355 | 0.33 | 0.38 | +0.05 | sell |
| Soleus Capital Management, L.P. | 157,800 | 55,500 | -102,300 | 0.52 | 0.21 | -0.32 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 55,212 | +55,212 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 22,204 | 50,868 | +28,664 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 180,207 | 45,052 | -135,155 | 1.05 | 0.39 | -0.65 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 31,595 | 43,934 | +12,339 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 31,800 | 40,700 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 40,000 | +40,000 | 0.00 | 0.47 | +0.47 | buy |
| JANE STREET GROUP, LLC | 20,132 | 39,566 | +19,434 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 40,919 | 38,773 | -2,146 | 0.02 | 0.02 | +0.00 | sell |
| RHUMBLINE ADVISERS | 26,923 | 38,008 | +11,085 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 35,181 | +35,181 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 34,664 | +34,664 | 0.00 | 0.01 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 33,516 | +33,516 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 43,151 | 32,862 | -10,289 | 0.01 | 0.01 | -0.00 | sell |
| BIT Capital GmbH | 31,323 | 31,223 | -100 | 0.10 | 0.12 | +0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 23,990 | 30,742 | +6,752 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 8,695 | 30,178 | +21,483 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 23,550 | 29,240 | +5,690 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,500 | 29,178 | +13,678 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,153 | 25,624 | +19,471 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 24,519 | +24,519 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 7,184 | 24,048 | +16,864 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 15,597 | 24,019 | +8,422 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 23,617 | 23,617 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 0 | 23,332 | +23,332 | 0.00 | 0.36 | +0.36 | buy |
| Legal & General Group Plc | 16,107 | 21,285 | +5,178 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,263 | 20,738 | +4,475 | 0.00 | 0.00 | +0.00 | buy |
| Ovata Capital Management Ltd | 40,000 | 20,000 | -20,000 | 0.78 | 0.46 | -0.33 | sell |
| TD ASSET MANAGEMENT INC | 0 | 19,800 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 19,500 | +19,500 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 83,000 | 19,300 | -63,700 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 19,343 | 19,213 | -130 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 15,691 | 18,100 | +2,409 | 0.02 | 0.02 | -0.00 | buy |
| MetLife Investment Management, LLC | 9,061 | 16,349 | +7,288 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 41,572 | 15,595 | -25,977 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 14,399 | +14,399 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 14,274 | +14,274 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 6,725 | 12,424 | +5,699 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 12,220 | +12,220 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 11,591 | 11,554 | -37 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,239 | 11,546 | +4,307 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 11,541 | +11,541 | 0.00 | 0.00 | +0.00 | buy |
| Parkwood LLC | 0 | 11,390 | +11,390 | 0.00 | 0.06 | +0.06 | buy |
| Alpine Global Management, LLC | 0 | 10,142 | +10,142 | 0.00 | 0.07 | +0.07 | buy |
| Qube Research & Technologies Ltd | 0 | 10,034 | +10,034 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 9,980 | +9,980 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 0 | 9,723 | +9,723 | 0.00 | 0.02 | +0.02 | buy |
| HARVEST MANAGEMENT LLC | 0 | 9,700 | +9,700 | 0.00 | 0.33 | +0.33 | buy |
| Invesco Ltd. | 7,807 | 9,653 | +1,846 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 9,500 | +9,500 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 9,409 | +9,409 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,100 | 9,007 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 9,134 | 8,958 | -176 | 0.00 | 0.00 | +0.00 | sell |
| Lester Murray Antman dba SimplyRich | 7,964 | 7,964 | 0 | 0.10 | 0.11 | +0.01 | hold |
| ADAR1 Capital Management, LLC | 14,000 | 7,891 | -6,109 | 0.14 | 0.07 | -0.08 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 7,890 | +7,890 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 10,960 | 7,807 | -3,153 | 0.00 | 0.00 | -0.00 | sell |