| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 150,000 | 750,000 | +600,000 | 0.59 | 3.62 | +3.03 | buy |
| Avidity Partners Management LP | 384,245 | 840,219 | +455,974 | 0.51 | 1.50 | +0.98 | buy |
| Cormorant Asset Management, LP | 750,000 | 1,050,000 | +300,000 | 1.24 | 2.54 | +1.30 | buy |
| Woodline Partners LP | 29,848 | 300,825 | +270,977 | 0.01 | 0.12 | +0.11 | buy |
| JANUS HENDERSON GROUP PLC | 1,965,546 | 1,801,843 | +163,703 | 0.04 | 0.04 | 0.00 | sell |
| LORD, ABBETT & CO. LLC | 542,373 | 702,607 | +160,234 | 0.07 | 0.10 | +0.03 | buy |
| Artal Group S.A. | 50,000 | 203,000 | +153,000 | 0.05 | 0.22 | +0.17 | buy |
| Ratan Capital Management LP | 20,000 | 105,757 | +85,757 | 0.40 | 1.34 | +0.94 | buy |
| Candriam S.C.A. | 80,005 | 112,004 | +31,999 | 0.02 | 0.03 | +0.01 | buy |
| SAMLYN CAPITAL, LLC | 296,391 | 324,703 | +28,312 | 0.19 | 0.23 | +0.04 | buy |
| Alyeska Investment Group, L.P. | 193,046 | 199,384 | +6,338 | 0.04 | 0.05 | +0.00 | buy |
| AlphaQuest LLC | 1,423 | 5,795 | +4,372 | 0.01 | 0.03 | 0.00 | buy |
| Rhenman & Partners Asset Management AB | 104,500 | 106,847 | +2,347 | 0.37 | 0.43 | +0.06 | buy |
| Belvedere Trading LLC | 5,637 | 5,857 | +220 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 11,591 | 11,554 | -37 | 0.01 | 0.01 | +0.00 | sell |
| BIT Capital GmbH | 31,323 | 31,223 | -100 | 0.09 | 0.10 | +0.01 | sell |
| Informed Momentum Co LLC | 55,973 | 55,618 | -355 | 0.33 | 0.38 | +0.05 | sell |
| ZACKS INVESTMENT MANAGEMENT | 40,919 | 38,773 | -2,146 | 0.02 | 0.02 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,743 | 6,090 | -3,653 | 0.05 | 0.04 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 14,000 | 7,891 | -6,109 | 0.14 | 0.07 | -0.08 | sell |
| Ovata Capital Management Ltd | 40,000 | 20,000 | -20,000 | 0.78 | 0.46 | -0.33 | sell |
| STEMPOINT CAPITAL LP | 121,642 | 92,949 | -28,693 | 1.22 | 1.15 | -0.08 | sell |
| Soleus Capital Management, L.P. | 157,800 | 55,500 | -102,300 | 0.52 | 0.21 | -0.32 | sell |
| Samsara BioCapital, LLC | 180,207 | 45,052 | -135,155 | 1.05 | 0.39 | -0.65 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,775,672 | 2,327,896 | -447,776 | 0.20 | 0.18 | -0.02 | sell |
| CITADEL ADVISORS LLC | 2,350,238 | 1,557,116 | -793,122 | 0.12 | 0.09 | -0.03 | sell |
| ORBIMED ADVISORS LLC | 4,275,553 | 2,979,828 | -1,295,725 | 2.96 | 2.48 | -0.47 | sell |
| BVF INC/IL | 2,919,818 | 441,528 | -2,478,290 | 3.02 | 0.52 | -2.50 | sell |