| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | 11,189,693 | 0 | 5.05 | 4.35 | -0.69 | hold |
| FMR LLC | 8,884,072 | 8,888,742 | +4,670 | 0.02 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,598,092 | 4,460,332 | -137,760 | 0.07 | 0.05 | -0.02 | sell |
| BlackRock, Inc. | 2,872,959 | 3,402,847 | +529,888 | 0.00 | 0.00 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 3,329,909 | 2,920,258 | -409,651 | 4.14 | 2.88 | -1.26 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,654,574 | 2,525,000 | -1,129,574 | 0.18 | 0.10 | -0.08 | sell |
| VANGUARD GROUP INC | 2,278,660 | 2,189,428 | -89,232 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 376,662 | 2,143,900 | +1,767,238 | 0.03 | 0.12 | +0.09 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,392,826 | 1,793,427 | +400,601 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 2,000,000 | 1,500,000 | -500,000 | 4.09 | 2.58 | -1.51 | sell |
| EcoR1 Capital, LLC | 1,469,818 | 1,469,818 | 0 | 2.36 | 2.01 | -0.34 | hold |
| STATE STREET CORP | 1,371,497 | 1,388,108 | +16,611 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,457,095 | 1,241,938 | -215,157 | 0.26 | 0.15 | -0.10 | sell |
| CITADEL ADVISORS LLC | 706,664 | 1,231,126 | +524,462 | 0.02 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 758,566 | 1,210,300 | +451,734 | 0.49 | 0.70 | +0.21 | buy |
| FRANKLIN RESOURCES INC | 1,186,479 | 1,069,195 | -117,284 | 0.01 | 0.01 | -0.00 | sell |
| Logos Global Management LP | 1,650,000 | 1,000,000 | -650,000 | 7.92 | 3.09 | -4.83 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 780,909 | 902,312 | +121,403 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 749,326 | 859,423 | +110,097 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 689,901 | 853,904 | +164,003 | 6.12 | 4.81 | -1.31 | buy |
| READYSTATE ASSET MANAGEMENT LP | 276,560 | 695,956 | +419,396 | 0.37 | 0.67 | +0.29 | buy |
| Pictet Asset Management Holding SA | 656,605 | 671,485 | +14,880 | 0.02 | 0.02 | -0.00 | buy |
| MPM BioImpact LLC | 567,193 | 614,282 | +47,089 | 2.63 | 2.46 | -0.17 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 393,477 | 492,361 | +98,884 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 44,443 | 457,012 | +412,569 | 0.05 | 0.97 | +0.91 | buy |
| First Turn Management, LLC | 430,163 | 447,420 | +17,257 | 2.34 | 1.93 | -0.41 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 376,496 | 376,496 | 0 | 2.10 | 1.03 | -1.07 | hold |
| GOLDMAN SACHS GROUP INC | 286,278 | 348,490 | +62,212 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 299,219 | 341,842 | +42,623 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 333,752 | +333,752 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 282,427 | 315,731 | +33,304 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 273,643 | 299,377 | +25,734 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 970,412 | 292,686 | -677,726 | 0.93 | 0.25 | -0.68 | sell |
| UBS Group AG | 488,480 | 292,533 | -195,947 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 224,788 | 285,288 | +60,500 | 0.01 | 0.01 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 408,678 | 258,678 | -150,000 | 0.04 | 0.02 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 261,262 | 255,585 | -5,677 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 303,194 | 247,873 | -55,321 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 135,308 | 247,424 | +112,116 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 192,372 | 246,916 | +54,544 | 0.01 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 368,935 | 229,989 | -138,946 | 0.02 | 0.01 | -0.01 | sell |
| Jump Financial, LLC | 94,030 | 228,430 | +134,400 | 0.04 | 0.07 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 82,273 | 214,362 | +132,089 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 204,466 | 210,266 | +5,800 | 0.32 | 0.30 | -0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 200,000 | +50,000 | 0.22 | 0.23 | +0.01 | buy |
| Squarepoint Ops LLC | 57,448 | 189,569 | +132,121 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 265,651 | 182,066 | -83,585 | 0.01 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 177,820 | 177,820 | 0 | 0.02 | 0.02 | -0.01 | hold |
| First Light Asset Management, LLC | 658,824 | 149,596 | -509,228 | 2.03 | 0.45 | -1.58 | sell |
| Cubist Systematic Strategies, LLC | 75,860 | 141,776 | +65,916 | 0.03 | 0.04 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 16,950 | 138,661 | +121,711 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 67,766 | 132,341 | +64,575 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 129,691 | 129,691 | 0 | 1.14 | 0.99 | -0.15 | hold |
| Bank of New York Mellon Corp | 89,370 | 114,699 | +25,329 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 174,350 | 113,749 | -60,601 | 0.04 | 0.02 | -0.02 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 186,394 | 111,362 | -75,032 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 104,382 | +104,382 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 60,580 | 99,858 | +39,278 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 168,972 | 96,174 | -72,798 | 0.05 | 0.03 | -0.03 | sell |
| Nuveen, LLC | 123,679 | 95,975 | -27,704 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 40,660 | 92,482 | +51,822 | 0.03 | 0.04 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 342,062 | 89,933 | -252,129 | 2.95 | 0.67 | -2.28 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 125,840 | 85,840 | -40,000 | 0.84 | 0.52 | -0.32 | sell |
| TWINBEECH CAPITAL LP | 77,437 | 81,882 | +4,445 | 0.04 | 0.04 | +0.00 | buy |
| Swiss National Bank | 79,100 | 79,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 76,601 | 76,601 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,745 | 74,740 | +5,995 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 27,964 | 74,715 | +46,751 | 0.01 | 0.02 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,965 | 70,262 | +19,297 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 65,636 | 65,236 | -400 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 74,556 | 62,436 | -12,120 | 0.78 | 0.53 | -0.25 | sell |
| ADAR1 Capital Management, LLC | 153,767 | 62,088 | -91,679 | 0.80 | 0.23 | -0.57 | sell |
| Quinn Opportunity Partners LLC | 51,893 | 59,893 | +8,000 | 0.10 | 0.12 | +0.02 | buy |
| RHUMBLINE ADVISERS | 42,650 | 59,391 | +16,741 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 153,848 | 55,536 | -98,312 | 0.01 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 141,627 | 55,127 | -86,500 | 0.44 | 0.16 | -0.28 | sell |
| Walleye Capital LLC | 11,380 | 53,476 | +42,096 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 45,937 | 50,065 | +4,128 | 0.02 | 0.01 | -0.01 | buy |
| TEMA ETFS LLC | 45,937 | 50,065 | +4,128 | 0.37 | 0.31 | -0.06 | buy |
| Atle Fund Management AB | 46,808 | 49,820 | +3,012 | 0.56 | 0.49 | -0.07 | buy |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 48,000 | 48,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 42,298 | 47,353 | +5,055 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 56,279 | 46,929 | -9,350 | 0.01 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 44,672 | 46,856 | +2,184 | 0.06 | 0.04 | -0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 50,106 | 45,411 | -4,695 | 0.02 | 0.01 | -0.01 | sell |
| Avalon Ventures Management, LLC | 0 | 43,300 | +43,300 | 0.00 | 5.26 | +5.26 | buy |
| Aquatic Capital Management LLC | 62,469 | 43,027 | -19,442 | 0.04 | 0.02 | -0.02 | sell |
| Engineers Gate Manager LP | 18,491 | 39,749 | +21,258 | 0.01 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 44,658 | 39,455 | -5,203 | 0.04 | 0.03 | -0.01 | sell |
| ZACKS INVESTMENT MANAGEMENT | 38,122 | 37,968 | -154 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,735 | 37,139 | +404 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 59,376 | 35,590 | -23,786 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 33,813 | +33,813 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 76,282 | 33,690 | -42,592 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 32,772 | +32,772 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 99,691 | 30,018 | -69,673 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 110,000 | 30,000 | -80,000 | 0.02 | 0.00 | -0.01 | sell |
| Tejara Capital Ltd | 0 | 29,800 | +29,800 | 0.00 | 0.32 | +0.32 | buy |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.01 | -0.00 | hold |