| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 376,662 | 2,143,900 | +1,767,238 | 0.03 | 0.12 | +0.09 | buy |
| BlackRock, Inc. | 2,872,959 | 3,402,847 | +529,888 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 706,664 | 1,231,126 | +524,462 | 0.02 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 758,566 | 1,210,300 | +451,734 | 0.49 | 0.70 | +0.21 | buy |
| READYSTATE ASSET MANAGEMENT LP | 276,560 | 695,956 | +419,396 | 0.37 | 0.67 | +0.29 | buy |
| Caption Management, LLC | 44,443 | 457,012 | +412,569 | 0.05 | 0.97 | +0.91 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,392,826 | 1,793,427 | +400,601 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 333,752 | +333,752 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 689,901 | 853,904 | +164,003 | 6.12 | 4.81 | -1.31 | buy |
| Jump Financial, LLC | 94,030 | 228,430 | +134,400 | 0.04 | 0.07 | +0.03 | buy |
| Squarepoint Ops LLC | 57,448 | 189,569 | +132,121 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 82,273 | 214,362 | +132,089 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 16,950 | 138,661 | +121,711 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 780,909 | 902,312 | +121,403 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 135,308 | 247,424 | +112,116 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 749,326 | 859,423 | +110,097 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 104,382 | +104,382 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 393,477 | 492,361 | +98,884 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 75,860 | 141,776 | +65,916 | 0.03 | 0.04 | +0.01 | buy |
| BARCLAYS PLC | 67,766 | 132,341 | +64,575 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 286,278 | 348,490 | +62,212 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 224,788 | 285,288 | +60,500 | 0.01 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 192,372 | 246,916 | +54,544 | 0.01 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 40,660 | 92,482 | +51,822 | 0.03 | 0.04 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 200,000 | +50,000 | 0.22 | 0.23 | +0.01 | buy |
| MPM BioImpact LLC | 567,193 | 614,282 | +47,089 | 2.63 | 2.46 | -0.17 | buy |
| ExodusPoint Capital Management, LP | 27,964 | 74,715 | +46,751 | 0.01 | 0.02 | +0.01 | buy |
| Avalon Ventures Management, LLC | 0 | 43,300 | +43,300 | 0.00 | 5.26 | +5.26 | buy |
| NORTHERN TRUST CORP | 299,219 | 341,842 | +42,623 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 11,380 | 53,476 | +42,096 | 0.00 | 0.01 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 60,580 | 99,858 | +39,278 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 33,813 | +33,813 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 282,427 | 315,731 | +33,304 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 32,772 | +32,772 | 0.00 | 0.01 | +0.01 | buy |
| Tejara Capital Ltd | 0 | 29,800 | +29,800 | 0.00 | 0.32 | +0.32 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 273,643 | 299,377 | +25,734 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 89,370 | 114,699 | +25,329 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 18,491 | 39,749 | +21,258 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,965 | 70,262 | +19,297 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 430,163 | 447,420 | +17,257 | 2.34 | 1.93 | -0.41 | buy |
| RHUMBLINE ADVISERS | 42,650 | 59,391 | +16,741 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,371,497 | 1,388,108 | +16,611 | 0.00 | 0.00 | -0.00 | buy |
| SummitTX Capital, L.P. | 0 | 15,909 | +15,909 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 656,605 | 671,485 | +14,880 | 0.02 | 0.02 | -0.00 | buy |
| DRW Securities, LLC | 0 | 12,566 | +12,566 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 11,970 | +11,970 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 11,290 | +11,290 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 10,054 | +10,054 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 258 | 9,698 | +9,440 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 15,345 | 23,683 | +8,338 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 51,893 | 59,893 | +8,000 | 0.10 | 0.12 | +0.02 | buy |
| WEXFORD CAPITAL LP | 0 | 6,541 | +6,541 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,745 | 74,740 | +5,995 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 204,466 | 210,266 | +5,800 | 0.32 | 0.30 | -0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,125 | 12,604 | +5,479 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,663 | 23,876 | +5,213 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 42,298 | 47,353 | +5,055 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,691 | 7,673 | +4,982 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,884,072 | 8,888,742 | +4,670 | 0.02 | 0.01 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 77,437 | 81,882 | +4,445 | 0.04 | 0.04 | +0.00 | buy |
| NEOS Investment Management LLC | 45,937 | 50,065 | +4,128 | 0.02 | 0.01 | -0.01 | buy |
| TEMA ETFS LLC | 45,937 | 50,065 | +4,128 | 0.37 | 0.31 | -0.06 | buy |
| OSAIC HOLDINGS, INC. | 0 | 3,468 | +3,468 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 3,187 | 6,248 | +3,061 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,884 | 21,935 | +3,051 | 0.01 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 46,808 | 49,820 | +3,012 | 0.56 | 0.49 | -0.07 | buy |
| Y-Intercept (Hong Kong) Ltd | 17,833 | 20,602 | +2,769 | 0.03 | 0.01 | -0.02 | buy |
| FNY Investment Advisers, LLC | 2,460 | 5,210 | +2,750 | 0.04 | 0.05 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,426 | 3,928 | +2,502 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,403 | 23,866 | +2,463 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 44,672 | 46,856 | +2,184 | 0.06 | 0.04 | -0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,994 | 9,054 | +2,060 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 12,000 | 14,000 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 7,765 | 9,253 | +1,488 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 2,668 | 3,679 | +1,011 | 0.02 | 0.03 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 3,200 | 4,020 | +820 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 9,513 | 10,284 | +771 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 35 | 752 | +717 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 632 | 1,048 | +416 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,735 | 37,139 | +404 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 371 | +371 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,947 | 2,286 | +339 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 11,761 | 12,057 | +296 | 0.00 | 0.00 | -0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 176 | 396 | +220 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,931 | 11,068 | +137 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 1 | 56 | +55 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 45 | 95 | +50 | 0.00 | 0.00 | +0.00 | buy |
| SIERRA OCEAN, LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 105 | 140 | +35 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,855 | 11,885 | +30 | 0.03 | 0.03 | -0.00 | buy |
| J.Safra Asset Management Corp | 66 | 86 | +20 | 0.00 | 0.00 | -0.00 | buy |
| Fortitude Family Office, LLC | 207 | 223 | +16 | 0.00 | 0.00 | -0.00 | buy |
| HUNTINGTON NATIONAL BANK | 43 | 58 | +15 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CIBC Private Wealth Group LLC | 171 | 171 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | 11,189,693 | 0 | 5.05 | 4.35 | -0.69 | hold |
| MACQUARIE GROUP LTD | 76,601 | 76,601 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 187 | 187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 177,820 | 177,820 | 0 | 0.02 | 0.02 | -0.01 | hold |