| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 758,566 | 1,210,300 | +451,734 | 0.49 | 0.70 | +0.21 | buy |
| READYSTATE ASSET MANAGEMENT LP | 276,560 | 695,956 | +419,396 | 0.37 | 0.67 | +0.29 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,392,826 | 1,793,427 | +400,601 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 689,901 | 853,904 | +164,003 | 6.12 | 4.81 | -1.31 | buy |
| JANUS HENDERSON GROUP PLC | 4,598,092 | 4,460,332 | +137,760 | 0.07 | 0.05 | 0.00 | sell |
| Aberdeen Group plc | 224,788 | 285,288 | +60,500 | 0.01 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 192,372 | 246,916 | +54,544 | 0.01 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 40,660 | 92,482 | +51,822 | 0.03 | 0.05 | 0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 200,000 | +50,000 | 0.22 | 0.23 | +0.01 | buy |
| MPM BioImpact LLC | 567,193 | 614,282 | +47,089 | 2.63 | 2.46 | -0.17 | buy |
| ExodusPoint Capital Management, LP | 27,964 | 74,715 | +46,751 | 0.01 | 0.02 | 0.00 | buy |
| First Turn Management, LLC | 430,163 | 447,420 | +17,257 | 2.34 | 1.93 | -0.41 | buy |
| Quinn Opportunity Partners LLC | 51,893 | 59,893 | +8,000 | 0.10 | 0.12 | +0.02 | buy |
| Rock Springs Capital Management LP | 204,466 | 210,266 | +5,800 | 0.32 | 0.30 | -0.01 | buy |
| TWINBEECH CAPITAL LP | 77,437 | 81,882 | +4,445 | 0.04 | 0.04 | +0.00 | buy |
| NEOS Investment Management LLC | 45,937 | 50,065 | +4,128 | 0.02 | 0.01 | -0.01 | buy |
| TEMA ETFS LLC | 45,937 | 50,065 | +4,128 | 0.37 | 0.31 | -0.06 | buy |
| Atle Fund Management AB | 46,808 | 49,820 | +3,012 | 0.56 | 0.49 | -0.07 | buy |
| FNY Investment Advisers, LLC | 2,460 | 5,210 | +2,750 | 0.04 | 0.05 | 0.00 | buy |
| DnB Asset Management AS | 7,765 | 9,253 | +1,488 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 2,668 | 3,679 | +1,011 | 0.02 | 0.03 | +0.01 | buy |
| ANTIPODES PARTNERS Ltd | 632 | 1,048 | +416 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,855 | 11,885 | +30 | 0.03 | 0.03 | -0.00 | buy |
| J.Safra Asset Management Corp | 66 | 86 | +20 | 0.00 | 0.00 | -0.00 | buy |
| Avanza Fonder AB | 3,049 | 2,960 | -89 | 0.00 | 0.00 | -0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 38,122 | 37,968 | -154 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 65,636 | 65,236 | -400 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 11,726 | 10,052 | -1,674 | 0.01 | 0.01 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 50,106 | 45,411 | -4,695 | 0.02 | 0.01 | -0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 16,601 | 9,508 | -7,093 | 0.01 | 0.01 | -0.01 | sell |
| Rafferty Asset Management, LLC | 56,279 | 46,929 | -9,350 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 74,556 | 62,436 | -12,120 | 0.78 | 0.53 | -0.25 | sell |
| Artia Global Partners LP | 38,100 | 20,000 | -18,100 | 0.30 | 0.12 | -0.18 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 125,840 | 85,840 | -40,000 | 0.78 | 0.47 | -0.32 | sell |
| Ratan Capital Management LP | 76,800 | 13,288 | -63,512 | 0.67 | 0.52 | -0.15 | sell |
| Rhenman & Partners Asset Management AB | 141,627 | 55,127 | -86,500 | 0.44 | 0.16 | -0.28 | sell |
| ADAR1 Capital Management, LLC | 153,767 | 62,088 | -91,679 | 0.80 | 0.23 | -0.57 | sell |
| Alyeska Investment Group, L.P. | 408,678 | 258,678 | -150,000 | 0.04 | 0.02 | -0.02 | sell |
| Woodline Partners LP | 1,457,095 | 1,241,938 | -215,157 | 0.26 | 0.15 | -0.10 | sell |
| STEMPOINT CAPITAL LP | 342,062 | 89,933 | -252,129 | 2.95 | 0.67 | -2.28 | sell |
| Paradigm Biocapital Advisors LP | 3,329,909 | 2,920,258 | -409,651 | 4.14 | 2.88 | -1.26 | sell |
| Cormorant Asset Management, LP | 2,000,000 | 1,500,000 | -500,000 | 4.06 | 2.58 | -1.48 | sell |
| First Light Asset Management, LLC | 658,824 | 149,596 | -509,228 | 2.03 | 0.45 | -1.58 | sell |
| Logos Global Management LP | 1,650,000 | 1,000,000 | -650,000 | 7.92 | 3.09 | -4.83 | sell |
| PERCEPTIVE ADVISORS LLC | 970,412 | 292,686 | -677,726 | 0.93 | 0.25 | -0.67 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,654,574 | 2,525,000 | -1,129,574 | 0.18 | 0.10 | -0.08 | sell |