| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 300,825 | 1,600,263 | +1,299,438 | 0.12 | 0.61 | +0.49 | buy |
| Paradigm Biocapital Advisors LP | 1,564,452 | 2,400,574 | +836,122 | 2.51 | 3.82 | +1.31 | buy |
| JANUS HENDERSON GROUP PLC | 1,801,843 | 2,523,406 | +721,563 | 0.04 | 0.06 | +0.02 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 471,736 | +471,736 | 0.00 | 2.97 | +2.97 | buy |
| VANGUARD GROUP INC | 1,561,758 | 1,847,930 | +286,172 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 136,430 | 395,875 | +259,445 | 0.02 | 0.06 | +0.04 | buy |
| Logos Global Management LP | 750,000 | 1,000,000 | +250,000 | 3.62 | 5.09 | +1.47 | buy |
| Prosight Management, LP | 0 | 205,000 | +205,000 | 0.00 | 2.36 | +2.36 | buy |
| MPM BioImpact LLC | 0 | 171,105 | +171,105 | 0.00 | 1.17 | +1.17 | buy |
| Sofinnova Investments, Inc. | 0 | 164,770 | +164,770 | 0.00 | 0.62 | +0.62 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,516 | 234,191 | +156,675 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 29,178 | 174,061 | +144,883 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 123,658 | +123,658 | 0.00 | 0.04 | +0.04 | buy |
| Ally Bridge Group (NY) LLC | 0 | 108,811 | +108,811 | 0.00 | 2.65 | +2.65 | buy |
| NORTHERN TRUST CORP | 194,373 | 266,498 | +72,125 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 65,098 | +65,098 | 0.00 | 0.15 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 63,215 | +63,215 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 81,798 | 140,464 | +58,666 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 48,051 | +48,051 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,777,600 | 7,824,675 | +47,075 | 0.02 | 0.02 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 40,000 | 80,000 | +40,000 | 0.47 | 0.70 | +0.24 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 35,181 | 74,273 | +39,092 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 624,104 | 662,594 | +38,490 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 32,335 | +32,335 | 0.00 | 0.08 | +0.08 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,624 | 55,638 | +30,014 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 112,004 | 137,105 | +25,101 | 0.03 | 0.04 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 24,472 | +24,472 | 0.00 | 0.03 | +0.03 | buy |
| Neo Ivy Capital Management | 0 | 20,674 | +20,674 | 0.00 | 0.30 | +0.30 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,751 | 20,343 | +17,592 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,220 | 29,745 | +17,525 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 14,888 | +14,888 | 0.00 | 0.01 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 0 | 13,500 | +13,500 | 0.00 | 0.01 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 23,617 | 34,647 | +11,030 | 0.00 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 60,578 | 69,801 | +9,223 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 8,108 | +8,108 | 0.00 | 0.00 | +0.00 | buy |
| Valence8 US LP | 0 | 7,857 | +7,857 | 0.00 | 0.16 | +0.16 | buy |
| FRANKLIN RESOURCES INC | 11,541 | 18,983 | +7,442 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 6,971 | +6,971 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,043 | 17,987 | +6,944 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 12,424 | 19,117 | +6,693 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,048 | 30,595 | +6,547 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 6,413 | +6,413 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15,595 | 21,476 | +5,881 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 5,270 | +5,270 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 0 | 5,251 | +5,251 | 0.00 | 0.01 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 5,201 | +5,201 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 5,140 | +5,140 | 0.00 | 0.11 | +0.11 | buy |
| ADAR1 Capital Management, LLC | 7,891 | 13,000 | +5,109 | 0.07 | 0.10 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 6,090 | 10,033 | +3,943 | 0.04 | 0.05 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 199,384 | 203,184 | +3,800 | 0.05 | 0.05 | -0.00 | buy |
| NEOS Investment Management LLC | 9,723 | 13,276 | +3,553 | 0.02 | 0.02 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 38,773 | 42,133 | +3,360 | 0.02 | 0.02 | -0.00 | buy |
| UBS Group AG | 50,868 | 54,194 | +3,326 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 5,518 | 8,381 | +2,863 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 5,044 | 7,463 | +2,419 | 0.01 | 0.02 | +0.00 | buy |
| Allianz Asset Management GmbH | 9,500 | 11,400 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,900 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,742 | 32,585 | +1,843 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,980 | 11,785 | +1,805 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 5,273 | 6,253 | +980 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 702,607 | 703,481 | +874 | 0.10 | 0.10 | +0.01 | buy |
| Legal & General Group Plc | 21,285 | 22,031 | +746 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 5,125 | 5,524 | +399 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,548 | 1,887 | +339 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 9,653 | 9,938 | +285 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 5,784 | 5,973 | +189 | 0.00 | 0.00 | +0.00 | buy |
| Plato Investment Management Ltd | 999 | 1,186 | +187 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 23,332 | 23,472 | +140 | 0.36 | 0.37 | +0.01 | buy |
| LRI Investments, LLC | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 1,103 | 1,168 | +65 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,137 | 2,178 | +41 | 0.04 | 0.05 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 35 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 21 | 41 | +20 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 25 | 32 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 49 | 55 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 169 | 173 | +4 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,747 | 2,747 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,165,652 | 9,165,652 | 0 | 5.08 | 4.80 | -0.28 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,609 | 3,609 | 0 | 0.00 | 0.00 | -0.00 | hold |
| J. Goldman & Co LP | 5,400 | 5,400 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MACQUARIE GROUP LTD | 76,601 | 76,601 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 133,000 | 133,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 187 | 187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 16,349 | 16,349 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUMMIT SECURITIES GROUP LLC | 700 | 700 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Allworth Financial LP | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 40,700 | 40,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cormorant Asset Management, LP | 1,050,000 | 1,050,000 | 0 | 2.56 | 2.53 | -0.03 | hold |
| EcoR1 Capital, LLC | 1,469,818 | 1,469,818 | 0 | 1.88 | 2.29 | +0.40 | hold |
| Avior Wealth Management, LLC | 111 | 111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rhenman & Partners Asset Management AB | 106,847 | 106,847 | 0 | 0.43 | 0.39 | -0.04 | hold |
| Lester Murray Antman dba SimplyRich | 7,964 | 7,964 | 0 | 0.11 | 0.10 | -0.00 | hold |
| Covestor Ltd | 3 | 3 | 0 | 0.00 | 0.00 | 0.00 | hold |