| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,165,652 | 9,165,652 | 0 | 5.08 | 4.80 | -0.28 | hold |
| FMR LLC | 7,777,600 | 7,824,675 | +47,075 | 0.02 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,801,843 | 2,523,406 | +721,563 | 0.04 | 0.06 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 1,564,452 | 2,400,574 | +836,122 | 2.51 | 3.82 | +1.31 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,327,896 | 2,075,000 | -252,896 | 0.18 | 0.17 | -0.01 | sell |
| VANGUARD GROUP INC | 1,561,758 | 1,847,930 | +286,172 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 300,825 | 1,600,263 | +1,299,438 | 0.12 | 0.61 | +0.49 | buy |
| EcoR1 Capital, LLC | 1,469,818 | 1,469,818 | 0 | 1.88 | 2.29 | +0.40 | hold |
| STATE STREET CORP | 1,401,234 | 1,361,178 | -40,056 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 2,979,828 | 1,258,566 | -1,721,262 | 2.48 | 1.05 | -1.44 | sell |
| Cormorant Asset Management, LP | 1,050,000 | 1,050,000 | 0 | 2.56 | 2.53 | -0.03 | hold |
| CITADEL ADVISORS LLC | 1,557,116 | 1,009,768 | -547,348 | 0.06 | 0.05 | -0.02 | sell |
| Logos Global Management LP | 750,000 | 1,000,000 | +250,000 | 3.62 | 5.09 | +1.47 | buy |
| LORD, ABBETT & CO. LLC | 702,607 | 703,481 | +874 | 0.10 | 0.10 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 624,104 | 662,594 | +38,490 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 840,219 | 562,000 | -278,219 | 1.50 | 1.30 | -0.19 | sell |
| Vestal Point Capital, LP | 725,000 | 485,000 | -240,000 | 2.26 | 1.74 | -0.53 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 471,736 | +471,736 | 0.00 | 2.97 | +2.97 | buy |
| Point72 Asset Management, L.P. | 136,430 | 395,875 | +259,445 | 0.02 | 0.06 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 344,672 | 315,735 | -28,937 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 194,373 | 266,498 | +72,125 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,516 | 234,191 | +156,675 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 205,000 | +205,000 | 0.00 | 2.36 | +2.36 | buy |
| Alyeska Investment Group, L.P. | 199,384 | 203,184 | +3,800 | 0.05 | 0.05 | -0.00 | buy |
| BARCLAYS PLC | 29,178 | 174,061 | +144,883 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 171,105 | +171,105 | 0.00 | 1.17 | +1.17 | buy |
| Sofinnova Investments, Inc. | 0 | 164,770 | +164,770 | 0.00 | 0.62 | +0.62 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 252,358 | 159,421 | -92,937 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 242,531 | 149,355 | -93,176 | 0.08 | 0.06 | -0.02 | sell |
| MORGAN STANLEY | 81,798 | 140,464 | +58,666 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 112,004 | 137,105 | +25,101 | 0.03 | 0.04 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 133,000 | 133,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Hudson Bay Capital Management LP | 0 | 123,658 | +123,658 | 0.00 | 0.04 | +0.04 | buy |
| Ally Bridge Group (NY) LLC | 0 | 108,811 | +108,811 | 0.00 | 2.65 | +2.65 | buy |
| Rhenman & Partners Asset Management AB | 106,847 | 106,847 | 0 | 0.43 | 0.39 | -0.04 | hold |
| Bank of New York Mellon Corp | 115,027 | 86,835 | -28,192 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 97,823 | 83,989 | -13,834 | 0.01 | 0.00 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 40,000 | 80,000 | +40,000 | 0.47 | 0.70 | +0.24 | buy |
| TWO SIGMA INVESTMENTS, LP | 103,601 | 77,192 | -26,409 | 0.01 | 0.01 | -0.00 | sell |
| MACQUARIE GROUP LTD | 76,601 | 76,601 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 35,181 | 74,273 | +39,092 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 60,578 | 69,801 | +9,223 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 77,246 | 65,690 | -11,556 | 0.01 | 0.01 | -0.00 | sell |
| E Fund Management Co., Ltd. | 0 | 65,098 | +65,098 | 0.00 | 0.15 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 63,215 | +63,215 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 119,395 | 62,799 | -56,596 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,624 | 55,638 | +30,014 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 50,868 | 54,194 | +3,326 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STEMPOINT CAPITAL LP | 92,949 | 49,415 | -43,534 | 1.15 | 0.67 | -0.47 | sell |
| MARSHALL WACE, LLP | 0 | 48,051 | +48,051 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 38,773 | 42,133 | +3,360 | 0.02 | 0.02 | -0.00 | buy |
| Swiss National Bank | 40,700 | 40,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 39,566 | 39,158 | -408 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 38,008 | 37,554 | -454 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 23,617 | 34,647 | +11,030 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,742 | 32,585 | +1,843 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 32,335 | +32,335 | 0.00 | 0.08 | +0.08 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,048 | 30,595 | +6,547 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,220 | 29,745 | +17,525 | 0.00 | 0.00 | +0.00 | buy |
| Ratan Capital Management LP | 105,757 | 28,800 | -76,957 | 1.36 | 0.35 | -1.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 29,240 | 27,640 | -1,600 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 30,178 | 26,194 | -3,984 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 24,472 | +24,472 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 23,332 | 23,472 | +140 | 0.36 | 0.37 | +0.01 | buy |
| Samsara BioCapital, LLC | 45,052 | 22,526 | -22,526 | 0.39 | 0.20 | -0.20 | sell |
| Legal & General Group Plc | 21,285 | 22,031 | +746 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15,595 | 21,476 | +5,881 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 20,674 | +20,674 | 0.00 | 0.30 | +0.30 | buy |
| DIMENSIONAL FUND ADVISORS LP | 24,019 | 20,372 | -3,647 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 2,751 | 20,343 | +17,592 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,738 | 20,160 | -578 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 12,424 | 19,117 | +6,693 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 11,541 | 18,983 | +7,442 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 19,213 | 18,392 | -821 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,043 | 17,987 | +6,944 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,349 | 16,349 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 32,862 | 16,142 | -16,720 | 0.01 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 15,085 | 14,993 | -92 | 0.00 | 0.00 | +0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 14,888 | +14,888 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 43,934 | 14,498 | -29,436 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 0 | 13,500 | +13,500 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 9,723 | 13,276 | +3,553 | 0.02 | 0.02 | +0.00 | buy |
| PROFUND ADVISORS LLC | 14,274 | 13,012 | -1,262 | 0.02 | 0.02 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 7,891 | 13,000 | +5,109 | 0.07 | 0.10 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,980 | 11,785 | +1,805 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 9,500 | 11,400 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 11,554 | 11,349 | -205 | 0.01 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,090 | 10,033 | +3,943 | 0.04 | 0.05 | +0.01 | buy |
| Ovata Capital Management Ltd | 20,000 | 10,000 | -10,000 | 0.46 | 0.19 | -0.26 | sell |
| Invesco Ltd. | 9,653 | 9,938 | +285 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 19,800 | 9,534 | -10,266 | 0.00 | 0.00 | -0.00 | sell |
| HARVEST MANAGEMENT LLC | 9,700 | 9,300 | -400 | 0.33 | 0.24 | -0.10 | sell |
| ROYAL BANK OF CANADA | 24,519 | 9,019 | -15,500 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 9,007 | 8,666 | -341 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,546 | 8,646 | -2,900 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 5,518 | 8,381 | +2,863 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 9,409 | 8,371 | -1,038 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 8,108 | +8,108 | 0.00 | 0.00 | +0.00 | buy |
| Lester Murray Antman dba SimplyRich | 7,964 | 7,964 | 0 | 0.11 | 0.10 | -0.00 | hold |