| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 300,825 | 1,600,263 | +1,299,438 | 0.12 | 0.61 | +0.49 | buy |
| Paradigm Biocapital Advisors LP | 1,564,452 | 2,400,574 | +836,122 | 2.51 | 3.82 | +1.31 | buy |
| JANUS HENDERSON GROUP PLC | 1,801,843 | 2,523,406 | +721,563 | 0.04 | 0.06 | 0.00 | buy |
| Logos Global Management LP | 750,000 | 1,000,000 | +250,000 | 2.53 | 4.90 | +2.37 | buy |
| Blue Owl Capital Holdings LP | 40,000 | 80,000 | +40,000 | 0.47 | 0.70 | +0.24 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 35,181 | 74,273 | +39,092 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 112,004 | 137,105 | +25,101 | 0.03 | 0.04 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 23,617 | 34,647 | +11,030 | 52.92 | 11.35 | -41.57 | buy |
| ADAR1 Capital Management, LLC | 7,891 | 13,000 | +5,109 | 0.07 | 0.10 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 6,090 | 10,033 | +3,943 | 0.04 | 0.05 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 199,384 | 203,184 | +3,800 | 0.05 | 0.05 | -0.00 | buy |
| NEOS Investment Management LLC | 9,723 | 13,276 | +3,553 | 0.02 | 0.02 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 38,773 | 42,133 | +3,360 | 0.02 | 0.02 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,980 | 11,785 | +1,805 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 14,274 | 13,012 | +1,262 | 0.02 | 0.02 | 0.00 | sell |
| DnB Asset Management AS | 5,273 | 6,253 | +980 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 702,607 | 703,481 | +874 | 0.10 | 0.10 | +0.01 | buy |
| Plato Investment Management Ltd | 999 | 1,186 | +187 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 23,332 | 23,472 | +140 | 0.36 | 0.37 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 2,137 | 2,178 | +41 | 0.04 | 0.05 | +0.00 | buy |
| FNY Investment Advisers, LLC | 650 | 600 | -50 | 0.02 | 0.01 | -0.01 | sell |
| BFSG, LLC | 400 | 300 | -100 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 11,554 | 11,349 | -205 | 0.01 | 0.01 | +0.00 | sell |
| FORA Capital, LLC | 4,858 | 4,599 | -259 | 0.02 | 0.02 | -0.00 | sell |
| HARVEST MANAGEMENT LLC | 9,700 | 9,300 | -400 | 0.31 | 0.21 | -0.10 | sell |
| Ovata Capital Management Ltd | 20,000 | 10,000 | -10,000 | 0.46 | 0.19 | -0.26 | sell |
| Rafferty Asset Management, LLC | 77,246 | 65,690 | -11,556 | 0.01 | 0.01 | -0.00 | sell |
| Samsara BioCapital, LLC | 45,052 | 22,526 | -22,526 | 0.39 | 0.20 | -0.20 | sell |
| STEMPOINT CAPITAL LP | 92,949 | 49,415 | -43,534 | 1.15 | 0.67 | -0.47 | sell |
| Ratan Capital Management LP | 105,757 | 28,800 | -76,957 | 1.34 | 0.35 | -0.99 | sell |
| Vestal Point Capital, LP | 725,000 | 485,000 | -240,000 | 2.26 | 1.74 | -0.53 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,327,896 | 2,075,000 | -252,896 | 0.18 | 0.17 | -0.01 | sell |
| Avidity Partners Management LP | 840,219 | 562,000 | -278,219 | 1.50 | 1.30 | -0.19 | sell |
| ORBIMED ADVISORS LLC | 2,979,828 | 1,258,566 | -1,721,262 | 2.48 | 1.05 | -1.44 | sell |