| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | 11,189,693 | 0 | 4.35 | 3.37 | -0.98 | hold |
| FMR LLC | 8,888,742 | 9,056,062 | +167,320 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,460,332 | 4,701,112 | +240,780 | 0.05 | 0.05 | +0.00 | buy |
| BlackRock, Inc. | 3,402,847 | 3,730,994 | +328,147 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,920,258 | 2,920,258 | 0 | 2.88 | 2.11 | -0.77 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,525,000 | 2,775,000 | +250,000 | 0.10 | 0.11 | +0.01 | buy |
| VANGUARD GROUP INC | 2,189,428 | 2,417,104 | +227,676 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,388,108 | 1,891,465 | +503,357 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,210,300 | 1,766,100 | +555,800 | 0.70 | 1.04 | +0.33 | buy |
| Point72 Asset Management, L.P. | 2,143,900 | 1,710,200 | -433,700 | 0.12 | 0.09 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,793,427 | 1,265,556 | -527,871 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 902,312 | 1,083,864 | +181,552 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,241,938 | 1,026,938 | -215,000 | 0.15 | 0.12 | -0.03 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 972,691 | +972,691 | 0.00 | 0.01 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 695,956 | 960,379 | +264,423 | 0.67 | 1.14 | +0.48 | buy |
| Logos Global Management LP | 1,000,000 | 935,000 | -65,000 | 3.09 | 2.26 | -0.83 | sell |
| FRANKLIN RESOURCES INC | 1,069,195 | 887,755 | -181,440 | 0.01 | 0.01 | -0.00 | sell |
| Prosight Management, LP | 853,904 | 865,350 | +11,446 | 4.81 | 5.08 | +0.27 | buy |
| Cormorant Asset Management, LP | 1,500,000 | 850,000 | -650,000 | 2.58 | 1.43 | -1.15 | sell |
| CITADEL ADVISORS LLC | 1,231,126 | 802,784 | -428,342 | 0.02 | 0.02 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 492,361 | 701,604 | +209,243 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 700,000 | +500,000 | 0.23 | 0.66 | +0.43 | buy |
| GOLDMAN SACHS GROUP INC | 348,490 | 655,108 | +306,618 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 447,420 | 639,699 | +192,279 | 1.93 | 2.35 | +0.42 | buy |
| MPM BioImpact LLC | 614,282 | 614,282 | 0 | 2.46 | 2.46 | -0.00 | hold |
| Pictet Asset Management Holding SA | 671,485 | 594,831 | -76,654 | 0.02 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 315,731 | 495,635 | +179,904 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 859,423 | 493,452 | -365,971 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 258,678 | 424,845 | +166,167 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 292,533 | 390,357 | +97,824 | 0.00 | 0.00 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 376,496 | 376,496 | 0 | 1.03 | 0.71 | -0.32 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 299,377 | 354,544 | +55,167 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 341,842 | 354,113 | +12,271 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 62,088 | 351,032 | +288,944 | 0.23 | 0.85 | +0.62 | buy |
| Aberdeen Group plc | 285,288 | 345,476 | +60,188 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 333,752 | 331,577 | -2,175 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 246,916 | 298,878 | +51,962 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 292,686 | 292,686 | 0 | 0.25 | 0.21 | -0.05 | hold |
| Cubist Systematic Strategies, LLC | 141,776 | 257,527 | +115,751 | 0.04 | 0.09 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 255,585 | 256,055 | +470 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 138,661 | 240,631 | +101,970 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 210,266 | 210,366 | +100 | 0.30 | 0.30 | -0.00 | buy |
| JPMORGAN CHASE & CO | 247,424 | 209,183 | -38,241 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 228,430 | 179,700 | -48,730 | 0.07 | 0.07 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 229,989 | 169,141 | -60,848 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 132,341 | 144,024 | +11,683 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 114,699 | 120,472 | +5,773 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 247,873 | 110,849 | -137,024 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 104,382 | 103,476 | -906 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 214,362 | 100,645 | -113,717 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 55,127 | 100,127 | +45,000 | 0.16 | 0.27 | +0.11 | buy |
| TUDOR INVESTMENT CORP ET AL | 113,749 | 98,556 | -15,193 | 0.02 | 0.02 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 99,858 | 97,473 | -2,385 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 95,975 | 95,629 | -346 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 65,236 | 92,302 | +27,066 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 457,012 | 90,000 | -367,012 | 0.97 | 0.13 | -0.84 | sell |
| ALGERT GLOBAL LLC | 92,482 | 88,217 | -4,265 | 0.04 | 0.04 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 85,840 | 85,840 | 0 | 0.52 | 0.50 | -0.02 | hold |
| JANE STREET GROUP, LLC | 33,813 | 81,322 | +47,509 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 76,601 | 76,601 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 46,929 | 76,196 | +29,267 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 79,100 | 74,600 | -4,500 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 111,362 | 66,325 | -45,037 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 189,569 | 66,161 | -123,408 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 74,740 | 64,988 | -9,752 | 0.00 | 0.00 | -0.00 | sell |
| Quinn Opportunity Partners LLC | 59,893 | 59,893 | 0 | 0.12 | 0.11 | -0.01 | hold |
| RHUMBLINE ADVISERS | 59,391 | 57,644 | -1,747 | 0.00 | 0.00 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 0 | 55,773 | +55,773 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 62,436 | 55,250 | -7,186 | 0.53 | 0.33 | -0.20 | sell |
| Ikarian Capital, LLC | 129,691 | 54,691 | -75,000 | 0.99 | 0.27 | -0.72 | sell |
| Avalon Ventures Management, LLC | 43,300 | 53,300 | +10,000 | 5.26 | 9.17 | +3.91 | buy |
| Hudson Bay Capital Management LP | 30,000 | 50,000 | +20,000 | 0.00 | 0.01 | +0.00 | buy |
| Atle Fund Management AB | 49,820 | 49,820 | 0 | 0.49 | 0.48 | -0.01 | hold |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 46,856 | 46,856 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Verition Fund Management LLC | 11,970 | 40,731 | +28,761 | 0.00 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 50,065 | 40,351 | -9,714 | 0.01 | 0.01 | -0.01 | sell |
| TEMA ETFS LLC | 50,065 | 40,351 | -9,714 | 0.31 | 0.08 | -0.23 | sell |
| GILDER GAGNON HOWE & CO LLC | 45,411 | 38,255 | -7,156 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 47,353 | 37,916 | -9,437 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,139 | 37,147 | +8 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 30,018 | 36,158 | +6,140 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 53,476 | 35,821 | -17,655 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,590 | 35,590 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 70,262 | 33,520 | -36,742 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 8,342 | 29,015 | +20,673 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,683 | 28,518 | +4,835 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Quadrature Capital Ltd | 0 | 26,861 | +26,861 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 18,299 | 24,469 | +6,170 | 0.00 | 0.00 | +0.00 | buy |
| Lester Murray Antman dba SimplyRich | 24,315 | 24,315 | 0 | 0.16 | 0.16 | +0.00 | hold |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 24,294 | +24,294 | 0.00 | 0.09 | +0.09 | buy |
| Raiffeisen Bank International AG | 0 | 24,000 | +24,000 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 23,876 | 23,876 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 46,856 | 23,647 | -23,209 | 0.04 | 0.02 | -0.03 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,866 | 22,364 | -1,502 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 12,566 | 21,543 | +8,977 | 0.02 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 11,290 | 18,953 | +7,663 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 55,536 | 17,502 | -38,034 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 21,935 | 16,743 | -5,192 | 0.00 | 0.00 | -0.00 | sell |