| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 972,691 | +972,691 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 1,210,300 | 1,766,100 | +555,800 | 0.70 | 1.04 | +0.33 | buy |
| STATE STREET CORP | 1,388,108 | 1,891,465 | +503,357 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 700,000 | +500,000 | 0.23 | 0.66 | +0.43 | buy |
| BlackRock, Inc. | 3,402,847 | 3,730,994 | +328,147 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 348,490 | 655,108 | +306,618 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 62,088 | 351,032 | +288,944 | 0.23 | 0.85 | +0.62 | buy |
| READYSTATE ASSET MANAGEMENT LP | 695,956 | 960,379 | +264,423 | 0.67 | 1.14 | +0.48 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,525,000 | 2,775,000 | +250,000 | 0.10 | 0.11 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 4,460,332 | 4,701,112 | +240,780 | 0.05 | 0.05 | +0.00 | buy |
| VANGUARD GROUP INC | 2,189,428 | 2,417,104 | +227,676 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 492,361 | 701,604 | +209,243 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 447,420 | 639,699 | +192,279 | 1.93 | 2.35 | +0.42 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 902,312 | 1,083,864 | +181,552 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 315,731 | 495,635 | +179,904 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,888,742 | 9,056,062 | +167,320 | 0.01 | 0.01 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 258,678 | 424,845 | +166,167 | 0.02 | 0.03 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 141,776 | 257,527 | +115,751 | 0.04 | 0.09 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 138,661 | 240,631 | +101,970 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 292,533 | 390,357 | +97,824 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 285,288 | 345,476 | +60,188 | 0.01 | 0.01 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 55,773 | +55,773 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 299,377 | 354,544 | +55,167 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 246,916 | 298,878 | +51,962 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 33,813 | 81,322 | +47,509 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 55,127 | 100,127 | +45,000 | 0.16 | 0.27 | +0.11 | buy |
| Rafferty Asset Management, LLC | 46,929 | 76,196 | +29,267 | 0.00 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 11,970 | 40,731 | +28,761 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 65,236 | 92,302 | +27,066 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 26,861 | +26,861 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 24,294 | +24,294 | 0.00 | 0.09 | +0.09 | buy |
| Raiffeisen Bank International AG | 0 | 24,000 | +24,000 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 8,342 | 29,015 | +20,673 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 30,000 | 50,000 | +20,000 | 0.00 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 15,463 | +15,463 | 0.00 | 0.03 | +0.03 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 14,206 | +14,206 | 0.00 | 0.11 | +0.11 | buy |
| NORTHERN TRUST CORP | 341,842 | 354,113 | +12,271 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 132,341 | 144,024 | +11,683 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 853,904 | 865,350 | +11,446 | 4.81 | 5.08 | +0.27 | buy |
| STIFEL FINANCIAL CORP | 0 | 11,307 | +11,307 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 10,010 | +10,010 | 0.00 | 0.06 | +0.06 | buy |
| Avalon Ventures Management, LLC | 43,300 | 53,300 | +10,000 | 5.26 | 9.17 | +3.91 | buy |
| Jain Global LLC | 0 | 9,844 | +9,844 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 12,566 | 21,543 | +8,977 | 0.02 | 0.03 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 8,961 | +8,961 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 8,454 | +8,454 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 11,290 | 18,953 | +7,663 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,052 | 16,438 | +6,386 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,673 | 13,875 | +6,202 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 18,299 | 24,469 | +6,170 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 30,018 | 36,158 | +6,140 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 114,699 | 120,472 | +5,773 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,683 | 28,518 | +4,835 | 0.00 | 0.00 | +0.00 | buy |
| Winthrop Capital Management, LLC | 0 | 4,327 | +4,327 | 0.00 | 0.03 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,508 | 11,413 | +1,905 | 0.01 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,054 | 10,900 | +1,846 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 1,259 | +1,259 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 752 | 1,873 | +1,121 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 3,679 | 4,452 | +773 | 0.03 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 255,585 | 256,055 | +470 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 0 | 416 | +416 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 386 | +386 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 3,468 | 3,790 | +322 | 0.00 | 0.00 | -0.00 | buy |
| Fourth Dimension Wealth, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 1,048 | 1,344 | +296 | 0.00 | 0.00 | -0.00 | buy |
| HighMark Wealth Management LLC | 0 | 265 | +265 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 210,266 | 210,366 | +100 | 0.30 | 0.30 | -0.00 | buy |
| COMERICA BANK | 28 | 104 | +76 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,699 | 1,774 | +75 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,770 | 1,810 | +40 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,286 | 2,323 | +37 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 6 | 28 | +22 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 140 | 156 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,139 | 37,147 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 15,135 | 15,141 | +6 | 0.03 | 0.03 | -0.00 | buy |
| Advisory Services Network, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 35,590 | 35,590 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 292,686 | 292,686 | 0 | 0.25 | 0.21 | -0.05 | hold |
| CIBC Private Wealth Group LLC | 171 | 171 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | 11,189,693 | 0 | 4.35 | 3.37 | -0.98 | hold |
| Atle Fund Management AB | 49,820 | 49,820 | 0 | 0.49 | 0.48 | -0.01 | hold |
| Handelsbanken Fonder AB | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KBC Group NV | 1,387 | 1,387 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 76,601 | 76,601 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 9,300 | 9,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 187 | 187 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 85,840 | 85,840 | 0 | 0.52 | 0.50 | -0.02 | hold |
| BNP Paribas Asset Management Holding S.A. | 371 | 371 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 23,876 | 23,876 | 0 | 0.00 | 0.00 | -0.00 | hold |
| J.Safra Asset Management Corp | 86 | 86 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quinn Opportunity Partners LLC | 59,893 | 59,893 | 0 | 0.12 | 0.11 | -0.01 | hold |
| MPM BioImpact LLC | 614,282 | 614,282 | 0 | 2.46 | 2.46 | -0.00 | hold |
| BFSG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 8,400 | 8,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Lester Murray Antman dba SimplyRich | 24,315 | 24,315 | 0 | 0.16 | 0.16 | +0.00 | hold |
| FNY Investment Advisers, LLC | 5,210 | 5,210 | 0 | 0.05 | 0.04 | -0.01 | hold |