| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,150,000 | 1,355,475 | +205,475 | 0.03 | 0.03 | +0.00 | buy |
| Cerity Partners LLC | 0 | 60,933 | +60,933 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 58,804 | +58,804 | 0.00 | 0.01 | +0.01 | buy |
| Janney Montgomery Scott LLC | 0 | 51,548 | +51,548 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 10,647 | 61,168 | +50,521 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 942,281 | 979,483 | +37,202 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 17,922 | 47,722 | +29,800 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 14,544 | 39,948 | +25,404 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 1,159 | 26,264 | +25,105 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,241 | 44,108 | +24,867 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 23,600 | +23,600 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 175,000 | 197,490 | +22,490 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 386,804 | 408,190 | +21,386 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 331,571 | 347,585 | +16,014 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 30,540 | 43,801 | +13,261 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 12,816 | +12,816 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 11,443 | +11,443 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 192,685 | 204,002 | +11,317 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 9,345 | +9,345 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 22,800 | 31,800 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,343 | +5,343 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,466 | 15,121 | +4,655 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,073 | 17,192 | +4,119 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 10,602 | 14,204 | +3,602 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 490 | 3,827 | +3,337 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 25 | 2,710 | +2,685 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,265 | 5,288 | +1,023 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 16,860 | 17,370 | +510 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,308 | 1,768 | +460 | 0.00 | 0.00 | -0.00 | buy |
| Raleigh Capital Management Inc. | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 243 | +243 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 1,667 | 1,734 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 56 | +56 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,317,927 | 3,317,927 | 0 | 0.72 | 0.71 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,706 | 1,706 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 4,579,818 | 4,579,818 | 0 | 1.24 | 1.23 | -0.02 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,165,652 | 9,165,652 | 0 | 1.82 | 1.54 | -0.28 | hold |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 10,614 | 10,614 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 360,414 | 360,414 | 0 | 1.11 | 0.60 | -0.51 | hold |
| Old Well Partners, LLC | 10,300 | 10,300 | 0 | 0.09 | 0.10 | +0.01 | hold |
| McGlone Suttner Wealth Management, Inc. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| US BANCORP \DE\ | 90 | 90 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,004 | 1,004 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 9,881 | 9,881 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 6,973 | 6,973 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 8,631 | 8,596 | -35 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,085 | 5,050 | -35 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 1,766 | 1,587 | -179 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 53,049 | 52,746 | -303 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 26,532 | 26,085 | -447 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 48,750 | 46,141 | -2,609 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 8,735 | 0 | -8,735 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 11,061 | 0 | -11,061 | 0.06 | 0.00 | -0.06 | sell |
| Trexquant Investment LP | 11,773 | 0 | -11,773 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 13,636 | 0 | -13,636 | 0.02 | 0.00 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 26,100 | 0 | -26,100 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 100,612 | 71,856 | -28,756 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 85,708 | 0 | -85,708 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF MONTREAL /CAN/ | 98,429 | 0 | -98,429 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 148,609 | 17,736 | -130,873 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 2,067,468 | 1,931,477 | -135,991 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 3,431,209 | 3,120,205 | -311,004 | 0.04 | 0.03 | -0.00 | sell |
| FMR LLC | 6,351,322 | 4,671,213 | -1,680,109 | 0.01 | 0.00 | -0.00 | sell |