| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,165,652 | 10,365,652 | +1,200,000 | 4.80 | 7.39 | +2.58 | buy |
| Paradigm Biocapital Advisors LP | 2,400,574 | 3,515,986 | +1,115,412 | 3.82 | 6.55 | +2.73 | buy |
| Cormorant Asset Management, LP | 1,050,000 | 2,100,000 | +1,050,000 | 2.53 | 6.17 | +3.65 | buy |
| JANUS HENDERSON GROUP PLC | 2,523,406 | 3,562,402 | +1,038,996 | 0.06 | 0.10 | +0.04 | buy |
| Holocene Advisors, LP | 0 | 1,015,060 | +1,015,060 | 0.00 | 0.18 | +0.18 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,075,000 | 3,061,750 | +986,750 | 0.17 | 0.29 | +0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 159,421 | 1,109,978 | +950,557 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 7,824,675 | 8,669,941 | +845,266 | 0.02 | 0.03 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 817,895 | +817,895 | 0.00 | 1.22 | +1.22 | buy |
| BANK OF AMERICA CORP /DE/ | 62,799 | 794,761 | +731,962 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 703,481 | 1,267,803 | +564,322 | 0.10 | 0.21 | +0.11 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 14,498 | 535,396 | +520,898 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 515,646 | +515,646 | 0.00 | 0.23 | +0.23 | buy |
| FRANKLIN RESOURCES INC | 18,983 | 497,287 | +478,304 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 0 | 384,797 | +384,797 | 0.00 | 0.02 | +0.02 | buy |
| First Turn Management, LLC | 0 | 383,602 | +383,602 | 0.00 | 3.68 | +3.68 | buy |
| CITADEL ADVISORS LLC | 1,009,768 | 1,360,878 | +351,110 | 0.05 | 0.07 | +0.02 | buy |
| First Light Asset Management, LLC | 0 | 313,782 | +313,782 | 0.00 | 1.61 | +1.61 | buy |
| READYSTATE ASSET MANAGEMENT LP | 32,335 | 339,639 | +307,304 | 0.08 | 0.77 | +0.69 | buy |
| BlackRock, Inc. | 2,422,636 | 2,725,813 | +303,177 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,847,930 | 2,136,332 | +288,402 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 9,938 | 284,662 | +274,724 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,600,263 | 1,852,187 | +251,924 | 0.61 | 0.67 | +0.06 | buy |
| Logos Global Management LP | 1,000,000 | 1,250,000 | +250,000 | 5.09 | 7.83 | +2.74 | buy |
| Tri Locum Partners LP | 0 | 236,407 | +236,407 | 0.00 | 2.62 | +2.62 | buy |
| Qube Research & Technologies Ltd | 0 | 229,390 | +229,390 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 395,875 | 621,383 | +225,508 | 0.06 | 0.09 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 29,745 | 242,409 | +212,664 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 0 | 204,466 | +204,466 | 0.00 | 0.42 | +0.42 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.95 | +0.95 | buy |
| Avidity Partners Management LP | 562,000 | 741,900 | +179,900 | 1.30 | 3.96 | +2.66 | buy |
| Siren, L.L.C. | 0 | 175,000 | +175,000 | 0.00 | 0.41 | +0.41 | buy |
| JPMORGAN CHASE & CO | 18,392 | 191,603 | +173,211 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 54,194 | 225,090 | +170,896 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 34,647 | 205,167 | +170,520 | 0.01 | 0.05 | +0.04 | buy |
| Artia Global Partners LP | 0 | 162,976 | +162,976 | 0.00 | 3.52 | +3.52 | buy |
| Ratan Capital Management LP | 28,800 | 179,307 | +150,507 | 0.35 | 1.47 | +1.12 | buy |
| Alyeska Investment Group, L.P. | 203,184 | 344,916 | +141,732 | 0.05 | 0.07 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 26,194 | 165,737 | +139,543 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 128,062 | +128,062 | 0.00 | 0.01 | +0.01 | buy |
| Prosight Management, LP | 205,000 | 329,768 | +124,768 | 2.36 | 4.95 | +2.58 | buy |
| Cutter Capital Management, LP | 0 | 120,000 | +120,000 | 0.00 | 2.63 | +2.63 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 116,102 | +116,102 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 49,415 | 145,876 | +96,461 | 0.67 | 1.96 | +1.29 | buy |
| BARCLAYS PLC | 174,061 | 263,970 | +89,909 | 0.00 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 164,770 | 253,262 | +88,492 | 0.62 | 0.99 | +0.37 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 74,273 | 156,874 | +82,601 | 0.00 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 82,005 | +82,005 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 140,464 | 217,831 | +77,367 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 74,691 | +74,691 | 0.00 | 1.14 | +1.14 | buy |
| DEUTSCHE BANK AG\ | 19,117 | 93,029 | +73,912 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 9,534 | 78,836 | +69,302 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 68,333 | +68,333 | 0.00 | 0.68 | +0.68 | buy |
| Trexquant Investment LP | 0 | 65,858 | +65,858 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 315,735 | 380,347 | +64,612 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 64,072 | +64,072 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 106,847 | 170,000 | +63,153 | 0.39 | 0.94 | +0.54 | buy |
| MPM BioImpact LLC | 171,105 | 230,000 | +58,895 | 1.17 | 1.75 | +0.58 | buy |
| CITIGROUP INC | 21,476 | 79,546 | +58,070 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 53,026 | +53,026 | 0.00 | 0.40 | +0.40 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 662,594 | 714,956 | +52,362 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 50,958 | +50,958 | 0.00 | 0.24 | +0.24 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.18 | +0.18 | buy |
| Caption Management, LLC | 0 | 48,532 | +48,532 | 0.00 | 0.11 | +0.11 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 48,000 | +48,000 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 23,472 | 69,715 | +46,243 | 0.37 | 1.39 | +1.02 | buy |
| TIG Advisors, LLC | 0 | 42,586 | +42,586 | 0.00 | 0.18 | +0.18 | buy |
| NORTHERN TRUST CORP | 266,498 | 308,800 | +42,302 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 11,349 | 52,379 | +41,030 | 0.01 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 24,472 | 64,961 | +40,489 | 0.03 | 0.08 | +0.05 | buy |
| Cubist Systematic Strategies, LLC | 0 | 40,349 | +40,349 | 0.00 | 0.04 | +0.04 | buy |
| Exome Asset Management LLC | 0 | 40,123 | +40,123 | 0.00 | 1.62 | +1.62 | buy |
| Atle Fund Management AB | 0 | 39,573 | +39,573 | 0.00 | 0.99 | +0.99 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 234,191 | 273,135 | +38,944 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 40,700 | 79,100 | +38,400 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,595 | 63,512 | +32,917 | 0.00 | 0.00 | +0.00 | buy |
| Troluce Capital Advisors LLC | 0 | 32,297 | +32,297 | 0.00 | 0.17 | +0.17 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 26,897 | +26,897 | 0.00 | 0.04 | +0.04 | buy |
| Proficio Capital Partners LLC | 0 | 25,271 | +25,271 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 16,142 | 41,176 | +25,034 | 0.00 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 23,501 | +23,501 | 0.00 | 0.01 | +0.01 | buy |
| Crestline Management, LP | 0 | 23,414 | +23,414 | 0.00 | 0.04 | +0.04 | buy |
| Quinn Opportunity Partners LLC | 0 | 20,000 | +20,000 | 0.00 | 0.08 | +0.08 | buy |
| Resolute Capital Asset Partners LLC | 0 | 20,000 | +20,000 | 0.00 | 0.58 | +0.58 | buy |
| ADAR1 Capital Management, LLC | 13,000 | 31,509 | +18,509 | 0.10 | 0.35 | +0.25 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,160 | 36,735 | +16,575 | 0.00 | 0.00 | +0.00 | buy |
| Lester Murray Antman dba SimplyRich | 7,964 | 24,315 | +16,351 | 0.10 | 0.37 | +0.27 | buy |
| Magnetar Financial LLC | 0 | 13,498 | +13,498 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 22,031 | 34,540 | +12,509 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 12,225 | +12,225 | 0.00 | 0.28 | +0.28 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 12,200 | +12,200 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 10,907 | +10,907 | 0.00 | 0.05 | +0.05 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,231 | +10,231 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 5,270 | 14,906 | +9,636 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 9,378 | +9,378 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 133,000 | 142,300 | +9,300 | 0.01 | 0.01 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 8,300 | +8,300 | 0.00 | 0.05 | +0.05 | buy |
| LPL Financial LLC | 0 | 8,202 | +8,202 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,585 | 40,733 | +8,148 | 0.00 | 0.01 | +0.00 | buy |