| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,165,652 | 10,365,652 | +1,200,000 | 4.80 | 7.39 | +2.58 | buy |
| Paradigm Biocapital Advisors LP | 2,400,574 | 3,515,986 | +1,115,412 | 3.82 | 6.55 | +2.73 | buy |
| Cormorant Asset Management, LP | 1,050,000 | 2,100,000 | +1,050,000 | 2.53 | 6.17 | +3.65 | buy |
| JANUS HENDERSON GROUP PLC | 2,523,406 | 3,562,402 | +1,038,996 | 0.06 | 0.10 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,075,000 | 3,061,750 | +986,750 | 0.17 | 0.29 | +0.12 | buy |
| LORD, ABBETT & CO. LLC | 703,481 | 1,267,803 | +564,322 | 0.10 | 0.21 | +0.11 | buy |
| READYSTATE ASSET MANAGEMENT LP | 32,335 | 339,639 | +307,304 | 0.08 | 0.77 | +0.69 | buy |
| Woodline Partners LP | 1,600,263 | 1,852,187 | +251,924 | 0.61 | 0.67 | +0.06 | buy |
| Logos Global Management LP | 1,000,000 | 1,250,000 | +250,000 | 5.09 | 7.83 | +2.74 | buy |
| Avidity Partners Management LP | 562,000 | 741,900 | +179,900 | 1.30 | 3.96 | +2.66 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 34,647 | 205,167 | +170,520 | 11.35 | 100.00 | +88.65 | buy |
| Ratan Capital Management LP | 28,800 | 179,307 | +150,507 | 0.35 | 1.47 | +1.12 | buy |
| Alyeska Investment Group, L.P. | 203,184 | 344,916 | +141,732 | 0.05 | 0.07 | +0.02 | buy |
| Prosight Management, LP | 205,000 | 329,768 | +124,768 | 2.29 | 4.88 | +2.59 | buy |
| STEMPOINT CAPITAL LP | 49,415 | 145,876 | +96,461 | 0.67 | 1.96 | +1.29 | buy |
| Sofinnova Investments, Inc. | 164,770 | 253,262 | +88,492 | 0.59 | 0.99 | +0.39 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 74,273 | 156,874 | +82,601 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 106,847 | 170,000 | +63,153 | 0.39 | 0.94 | +0.54 | buy |
| MPM BioImpact LLC | 171,105 | 230,000 | +58,895 | 1.17 | 1.75 | +0.58 | buy |
| HighVista Strategies LLC | 23,472 | 69,715 | +46,243 | 0.37 | 1.39 | +1.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 11,349 | 52,379 | +41,030 | 0.01 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 24,472 | 64,961 | +40,489 | 0.03 | 0.08 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 13,000 | 31,509 | +18,509 | 0.10 | 0.35 | +0.25 | buy |
| Lester Murray Antman dba SimplyRich | 7,964 | 24,315 | +16,351 | 0.10 | 0.37 | +0.27 | buy |
| PROFUND ADVISORS LLC | 13,012 | 10,206 | +2,806 | 0.02 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,033 | 11,128 | +1,095 | 0.05 | 0.06 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 11,785 | 12,713 | +928 | 0.01 | 0.02 | +0.00 | buy |
| J.Safra Asset Management Corp | 7 | 10 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 300 | 100 | -200 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 6,253 | 5,778 | -475 | 0.00 | 0.00 | +0.00 | sell |
| E Fund Management Co., Ltd. | 65,098 | 64,568 | -530 | 0.15 | 0.17 | +0.02 | sell |
| FNY Investment Advisers, LLC | 600 | 35 | -565 | 0.01 | 0.00 | -0.01 | sell |
| Chicago Partners Investment Group LLC | 5,251 | 4,621 | -630 | 0.01 | 0.01 | -0.00 | sell |
| Plato Investment Management Ltd | 1,186 | 498 | -688 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 7,400 | 6,500 | -900 | 0.01 | 0.01 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,178 | 1,156 | -1,022 | 0.05 | 0.03 | -0.02 | sell |
| ZACKS INVESTMENT MANAGEMENT | 42,133 | 38,173 | -3,960 | 0.02 | 0.02 | +0.00 | sell |
| NEOS Investment Management LLC | 13,276 | 5,223 | -8,053 | 0.02 | 0.01 | -0.01 | sell |
| Samsara BioCapital, LLC | 22,526 | 11,263 | -11,263 | 0.20 | 0.08 | -0.11 | sell |
| Rafferty Asset Management, LLC | 65,690 | 52,168 | -13,522 | 0.01 | 0.01 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 108,811 | 90,292 | -18,519 | 2.65 | 4.14 | +1.50 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 471,736 | 429,392 | -42,344 | 2.97 | 2.78 | -0.19 | sell |
| Hudson Bay Capital Management LP | 123,658 | 30,000 | -93,658 | 0.02 | 0.01 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 1,258,566 | 758,566 | -500,000 | 1.05 | 0.84 | -0.20 | sell |