| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | 11,189,693 | 0 | 3.37 | 1.58 | -1.79 | hold |
| JANUS HENDERSON GROUP PLC | 4,701,112 | 5,350,453 | +649,341 | 0.05 | 0.03 | -0.02 | buy |
| BlackRock, Inc. | 3,730,994 | 4,080,200 | +349,206 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,891,465 | 3,853,951 | +1,962,486 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 9,056,062 | 3,512,384 | -5,543,678 | 0.01 | 0.00 | -0.01 | sell |
| VANGUARD GROUP INC | 2,417,104 | 2,906,386 | +489,282 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 865,350 | 2,392,523 | +1,527,173 | 5.08 | 6.82 | +1.74 | buy |
| ORBIMED ADVISORS LLC | 1,766,100 | 1,954,426 | +188,326 | 1.04 | 0.55 | -0.48 | buy |
| TCG Crossover Management, LLC | 0 | 1,789,617 | +1,789,617 | 0.00 | 0.82 | +0.82 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 701,604 | 1,610,186 | +908,582 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 424,845 | 1,301,089 | +876,244 | 0.03 | 0.05 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,083,864 | 1,113,582 | +29,718 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 802,784 | 1,104,144 | +301,360 | 0.02 | 0.01 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 655,108 | 1,073,656 | +418,548 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,026,938 | 1,027,221 | +283 | 0.12 | 0.05 | -0.06 | buy |
| Logos Global Management LP | 935,000 | 1,000,000 | +65,000 | 2.26 | 0.92 | -1.34 | buy |
| Point72 Asset Management, L.P. | 1,710,200 | 961,819 | -748,381 | 0.09 | 0.02 | -0.07 | sell |
| READYSTATE ASSET MANAGEMENT LP | 960,379 | 885,895 | -74,484 | 1.14 | 0.54 | -0.60 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 885,551 | +885,551 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,265,556 | 744,466 | -521,090 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 493,452 | 738,330 | +244,878 | 0.00 | 0.00 | -0.00 | buy |
| Cormorant Asset Management, LP | 850,000 | 650,000 | -200,000 | 1.43 | 0.51 | -0.92 | sell |
| MORGAN STANLEY | 495,635 | 618,385 | +122,750 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 390,357 | 590,060 | +199,703 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 81,322 | 540,233 | +458,911 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 103,476 | 471,009 | +367,533 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,775,000 | 400,000 | -2,375,000 | 0.11 | 0.01 | -0.10 | sell |
| Squarepoint Ops LLC | 66,161 | 390,952 | +324,791 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 354,544 | 390,506 | +35,962 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 887,755 | 385,301 | -502,454 | 0.01 | 0.00 | -0.00 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 376,496 | 376,496 | 0 | 0.71 | 0.46 | -0.25 | hold |
| University of Wisconsin Foundation | 0 | 362,000 | +362,000 | 0.00 | 4.20 | +4.20 | buy |
| Rock Springs Capital Management LP | 210,366 | 358,798 | +148,432 | 0.30 | 0.25 | -0.05 | buy |
| NORTHERN TRUST CORP | 354,113 | 340,406 | -13,707 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 35,821 | 323,017 | +287,196 | 0.01 | 0.03 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 100,645 | 289,808 | +189,163 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 90,000 | 272,500 | +182,500 | 0.13 | 0.17 | +0.04 | buy |
| Pictet Asset Management Holding SA | 594,831 | 272,251 | -322,580 | 0.01 | 0.00 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 298,878 | 267,051 | -31,827 | 0.01 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 351,032 | 245,452 | -105,580 | 0.85 | 0.25 | -0.60 | sell |
| Rhenman & Partners Asset Management AB | 100,127 | 225,377 | +125,250 | 0.27 | 0.29 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 240,631 | 224,294 | -16,337 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 144,024 | 221,233 | +77,209 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 110,849 | 216,005 | +105,156 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 88,217 | 183,367 | +95,150 | 0.04 | 0.04 | +0.00 | buy |
| Rafferty Asset Management, LLC | 76,196 | 175,248 | +99,052 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 209,183 | 170,509 | -38,674 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 13,217 | 170,484 | +157,267 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 161,548 | +161,548 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 161,427 | +161,427 | 0.00 | 0.06 | +0.06 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 85,840 | 157,840 | +72,000 | 0.50 | 0.46 | -0.04 | buy |
| Bank of New York Mellon Corp | 120,472 | 122,066 | +1,594 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 50,000 | 110,000 | +60,000 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 104,100 | +104,100 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 100,000 | +100,000 | 0.00 | 0.43 | +0.43 | buy |
| Jump Financial, LLC | 179,700 | 96,684 | -83,016 | 0.07 | 0.02 | -0.05 | sell |
| Nuveen, LLC | 95,629 | 96,416 | +787 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 89,589 | +89,589 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 29,015 | 79,817 | +50,802 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 98,556 | 79,158 | -19,398 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 74,600 | 77,100 | +2,500 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66,325 | 75,498 | +9,173 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 64,512 | +64,512 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 16,438 | 64,022 | +47,584 | 0.01 | 0.03 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 63,544 | +63,544 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 58,810 | +58,810 | 0.00 | 0.06 | +0.06 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 46,856 | 57,363 | +10,507 | 0.03 | 0.04 | +0.01 | buy |
| CONGRESS ASSET MANAGEMENT CO | 55,773 | 57,342 | +1,569 | 0.01 | 0.01 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 56,497 | +56,497 | 0.00 | 0.07 | +0.07 | buy |
| Aquatic Capital Management LLC | 0 | 52,421 | +52,421 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 57,644 | 52,361 | -5,283 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 49,500 | 49,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 28,518 | 47,919 | +19,401 | 0.00 | 0.00 | -0.00 | buy |
| Raiffeisen Bank International AG | 24,000 | 46,000 | +22,000 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 45,453 | +45,453 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 37,916 | 43,467 | +5,551 | 0.00 | 0.00 | -0.00 | buy |
| Freestone Grove Partners LP | 0 | 41,806 | +41,806 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 55,250 | 41,443 | -13,807 | 0.33 | 0.15 | -0.18 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 38,875 | +38,875 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,520 | 38,487 | +4,967 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 40,351 | 37,647 | -2,704 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,147 | 37,320 | +173 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 40,351 | 37,092 | -3,259 | 0.08 | 0.04 | -0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64,988 | 36,555 | -28,433 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,590 | 35,590 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 169,141 | 35,237 | -133,904 | 0.01 | 0.00 | -0.01 | sell |
| Quadrature Capital Ltd | 26,861 | 33,002 | +6,141 | 0.01 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 32,707 | +32,707 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 36,158 | 32,170 | -3,988 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 0 | 31,800 | +31,800 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,364 | 30,148 | +7,784 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 24,469 | 28,322 | +3,853 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 0 | 27,942 | +27,942 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 18,953 | 27,691 | +8,738 | 0.00 | 0.00 | -0.00 | buy |
| Rangeley Capital, LLC | 0 | 25,414 | +25,414 | 0.00 | 0.30 | +0.30 | buy |
| Lester Murray Antman dba SimplyRich | 24,315 | 24,315 | 0 | 0.16 | 0.09 | -0.07 | hold |
| Quantinno Capital Management LP | 0 | 24,218 | +24,218 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,515 | 24,218 | +18,703 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,876 | 23,876 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OXFORD ASSET MANAGEMENT LLP | 14,206 | 22,811 | +8,605 | 0.11 | 0.11 | -0.00 | buy |