| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Prosight Management, LP | 865,350 | 2,392,523 | +1,527,173 | 4.93 | 6.82 | +1.89 | buy |
| Alyeska Investment Group, L.P. | 424,845 | 1,301,089 | +876,244 | 0.03 | 0.05 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 1,766,100 | 1,954,426 | +188,326 | 1.04 | 0.55 | -0.48 | buy |
| Rock Springs Capital Management LP | 210,366 | 358,798 | +148,432 | 0.30 | 0.25 | -0.05 | buy |
| Rhenman & Partners Asset Management AB | 100,127 | 225,377 | +125,250 | 0.27 | 0.29 | +0.02 | buy |
| Rafferty Asset Management, LLC | 76,196 | 175,248 | +99,052 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 85,840 | 157,840 | +72,000 | 0.44 | 0.42 | -0.02 | buy |
| Logos Global Management LP | 935,000 | 1,000,000 | +65,000 | 2.26 | 0.92 | -1.34 | buy |
| PROFUND ADVISORS LLC | 16,438 | 64,022 | +47,584 | 0.01 | 0.03 | 0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 23,647 | 57,363 | +33,716 | 0.02 | 0.04 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 298,878 | 267,051 | +31,827 | 0.01 | 0.00 | -0.00 | sell |
| Raiffeisen Bank International AG | 24,000 | 46,000 | +22,000 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 4,452 | 17,388 | +12,936 | 0.03 | 0.07 | +0.03 | buy |
| DnB Asset Management AS | 8,919 | 17,274 | +8,355 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 5,210 | 10,300 | +5,090 | 0.04 | 0.04 | -0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 55,773 | 57,342 | +1,569 | 0.01 | 0.01 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,293 | 1,181 | -112 | 0.00 | 0.00 | -0.00 | sell |
| ANTIPODES PARTNERS Ltd | 1,344 | 720 | -624 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,534 | 9,801 | -733 | 0.02 | 0.01 | -0.01 | sell |
| NEOS Investment Management LLC | 40,351 | 37,647 | -2,704 | 0.01 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 40,351 | 37,092 | -3,259 | 0.08 | 0.04 | -0.04 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 24,294 | 18,172 | -6,122 | 0.09 | 0.04 | -0.05 | sell |
| HighVista Strategies LLC | 55,250 | 41,443 | -13,807 | 0.33 | 0.15 | -0.18 | sell |
| READYSTATE ASSET MANAGEMENT LP | 960,379 | 885,895 | -74,484 | 1.14 | 0.54 | -0.60 | sell |
| ADAR1 Capital Management, LLC | 351,032 | 245,452 | -105,580 | 0.85 | 0.25 | -0.60 | sell |
| Cormorant Asset Management, LP | 850,000 | 650,000 | -200,000 | 1.43 | 0.41 | -1.02 | sell |
| T. Rowe Price Investment Management, Inc. | 972,691 | 1,726 | -970,965 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,775,000 | 400,000 | -2,375,000 | 0.11 | 0.01 | -0.10 | sell |