| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Corvex Management LP | 3,058,629 | 3,228,149 | +169,520 | 13.23 | 8.24 | -4.99 | buy |
| Casdin Capital, LLC | 3,007,164 | 3,007,164 | 0 | 24.29 | 14.62 | -9.67 | hold |
| LMR Partners LLP | 2,135,439 | 2,135,439 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BlackRock, Inc. | 1,560,094 | 1,550,708 | -9,386 | 0.00 | 0.00 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,018,261 | 1,369,108 | +350,847 | 0.55 | 0.37 | -0.18 | buy |
| GOLDMAN SACHS GROUP INC | 1,220,502 | 1,334,980 | +114,478 | 0.02 | 0.01 | -0.01 | buy |
| ARK Investment Management LLC | 604,561 | 1,324,583 | +720,022 | 0.52 | 0.66 | +0.14 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 809,210 | 775,269 | -33,941 | 0.29 | 0.16 | -0.13 | sell |
| Zweig-DiMenna Associates LLC | 597,825 | 689,290 | +91,465 | 5.52 | 6.21 | +0.69 | buy |
| CITADEL ADVISORS LLC | 182,351 | 647,401 | +465,050 | 0.02 | 0.03 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 381,725 | 638,800 | +257,075 | 0.57 | 0.58 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 381,725 | 633,457 | +251,732 | 0.03 | 0.03 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 505,341 | 610,073 | +104,732 | 0.02 | 0.01 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 1,092,988 | 607,221 | -485,767 | 0.03 | 0.01 | -0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 504,567 | 549,147 | +44,580 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 786,466 | 540,229 | -246,237 | 0.01 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 506,091 | 532,235 | +26,144 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 55,000 | 523,463 | +468,463 | 1.48 | 5.51 | +4.03 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 920,587 | 479,418 | -441,169 | 3.37 | 1.42 | -1.94 | sell |
| STATE STREET CORP | 456,258 | 472,445 | +16,187 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 467,197 | 467,197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 459,015 | +459,015 | 0.00 | 0.49 | +0.49 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 198,926 | 358,978 | +160,052 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 384,750 | 341,005 | -43,745 | 0.01 | 0.00 | -0.00 | sell |
| Capital International Investors | 283,248 | 324,588 | +41,340 | 0.01 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 227,586 | 315,508 | +87,922 | 0.01 | 0.00 | -0.00 | buy |
| GAGNON SECURITIES LLC | 253,534 | 303,149 | +49,615 | 6.71 | 4.49 | -2.22 | buy |
| FMR LLC | 832,738 | 295,621 | -537,117 | 0.01 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 109,188 | 265,791 | +156,603 | 0.00 | 0.00 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 198,770 | 261,370 | +62,600 | 0.95 | 0.50 | -0.45 | buy |
| Vestal Point Capital, LP | 0 | 250,000 | +250,000 | 0.00 | 0.45 | +0.45 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 258,745 | 249,432 | -9,313 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 243,780 | 243,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| First Light Asset Management, LLC | 0 | 242,927 | +242,927 | 0.00 | 1.40 | +1.40 | buy |
| Science & Technology Partners, L.P. | 201,264 | 241,200 | +39,936 | 7.31 | 4.06 | -3.26 | buy |
| BANK OF AMERICA CORP /DE/ | 132,150 | 234,606 | +102,456 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 0 | 230,096 | +230,096 | 0.00 | 0.02 | +0.02 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 58,044 | 209,887 | +151,843 | 0.08 | 0.14 | +0.07 | buy |
| FRED ALGER MANAGEMENT, LLC | 266,636 | 202,771 | -63,865 | 0.14 | 0.06 | -0.08 | sell |
| AMERIPRISE FINANCIAL INC | 117,057 | 195,889 | +78,832 | 0.00 | 0.00 | -0.00 | buy |
| Alamea Verwaltungs GmbH | 185,989 | 185,989 | 0 | 14.25 | 8.85 | -5.40 | hold |
| Qube Research & Technologies Ltd | 75,408 | 184,514 | +109,106 | 0.01 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 198,621 | 175,767 | -22,854 | 0.00 | 0.00 | -0.00 | sell |
| ASHFORD CAPITAL MANAGEMENT INC | 132,326 | 174,512 | +42,186 | 1.92 | 1.38 | -0.53 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,030 | 170,615 | -6,415 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 2,710 | 153,721 | +151,011 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 57,316 | 153,716 | +96,400 | 0.01 | 0.02 | +0.00 | buy |
| Capital Research Global Investors | 122,666 | 151,055 | +28,389 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 65,955 | 149,906 | +83,951 | 0.01 | 0.01 | +0.00 | buy |
| Gagnon Advisors, LLC | 127,062 | 148,225 | +21,163 | 10.49 | 7.00 | -3.49 | buy |
| ROYCE & ASSOCIATES LP | 75,783 | 140,513 | +64,730 | 0.10 | 0.09 | -0.01 | buy |
| Engineers Gate Manager LP | 1,575 | 132,962 | +131,387 | 0.00 | 0.11 | +0.10 | buy |
| Q Global Advisors, LLC | 111,701 | 111,701 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TORONTO DOMINION BANK | 106,050 | 105,950 | -100 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 81,963 | 102,929 | +20,966 | 0.01 | 0.00 | -0.00 | buy |
| Portolan Capital Management, LLC | 55,776 | 102,575 | +46,799 | 0.39 | 0.35 | -0.04 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 55,000 | 100,000 | +45,000 | 0.91 | 0.98 | +0.07 | buy |
| Granahan Investment Management, LLC | 30,910 | 96,605 | +65,695 | 0.17 | 0.30 | +0.13 | buy |
| Rockefeller Capital Management L.P. | 562 | 96,590 | +96,028 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 205,895 | 95,128 | -110,767 | 0.04 | 0.01 | -0.03 | sell |
| Palisades Investment Partners, LLC | 87,164 | 91,996 | +4,832 | 4.28 | 2.32 | -1.97 | buy |
| T. Rowe Price Investment Management, Inc. | 584,150 | 86,082 | -498,068 | 0.05 | 0.00 | -0.04 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 59,861 | 77,419 | +17,558 | 0.03 | 0.03 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 58,458 | 77,369 | +18,911 | 0.01 | 0.01 | -0.00 | buy |
| Trexquant Investment LP | 62,194 | 77,350 | +15,156 | 0.07 | 0.04 | -0.04 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 61,911 | 76,383 | +14,472 | 0.06 | 0.04 | -0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 75,795 | +75,795 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 62,050 | 74,602 | +12,552 | 0.01 | 0.00 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 54,038 | 71,572 | +17,534 | 0.22 | 0.17 | -0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,664 | 70,105 | +58,441 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE GROUP LLC | 55,103 | 66,977 | +11,874 | 0.29 | 0.18 | -0.11 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 26,975 | 63,505 | +36,530 | 0.00 | 0.00 | +0.00 | buy |
| Legal Advantage Investments, Inc. | 59,650 | 61,675 | +2,025 | 3.59 | 2.05 | -1.55 | buy |
| Impax Asset Management Group plc | 60,000 | 60,000 | 0 | 0.05 | 0.03 | -0.02 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 59,948 | 58,876 | -1,072 | 0.00 | 0.00 | -0.00 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 31,973 | 57,759 | +25,786 | 0.29 | 0.28 | -0.01 | buy |
| Meridiem Capital Partners LP | 20,807 | 55,585 | +34,778 | 0.17 | 0.23 | +0.07 | buy |
| AXIOM INVESTORS LLC /DE | 68,855 | 51,006 | -17,849 | 0.08 | 0.04 | -0.04 | sell |
| UBS Group AG | 89,190 | 50,825 | -38,365 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 39,272 | 50,778 | +11,506 | 0.49 | 0.34 | -0.15 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 18,182 | 46,377 | +28,195 | 0.00 | 0.00 | +0.00 | buy |
| Future Fund LLC | 12,053 | 43,871 | +31,818 | 0.50 | 0.99 | +0.49 | buy |
| LORD, ABBETT & CO. LLC | 518,304 | 42,648 | -475,656 | 0.21 | 0.01 | -0.20 | sell |
| Nuveen, LLC | 42,625 | 41,944 | -681 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 73,007 | 41,271 | -31,736 | 0.02 | 0.00 | -0.01 | sell |
| Slow Capital, Inc. | 38,714 | 40,457 | +1,743 | 0.60 | 0.34 | -0.26 | buy |
| Swiss National Bank | 39,600 | 40,000 | +400 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,027 | 38,300 | -12,727 | 0.01 | 0.00 | -0.01 | sell |
| RBF Capital, LLC | 37,340 | 37,340 | 0 | 0.22 | 0.12 | -0.10 | hold |
| TD ASSET MANAGEMENT INC | 34,884 | 34,884 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 34,562 | +34,562 | 0.00 | 0.05 | +0.05 | buy |
| Kovack Advisors, Inc. | 0 | 33,960 | +33,960 | 0.00 | 0.12 | +0.12 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 33,894 | +33,894 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 27,148 | 33,674 | +6,526 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 33,540 | +33,540 | 0.00 | 0.01 | +0.01 | buy |
| One Capital Management, LLC | 12,053 | 33,306 | +21,253 | 0.05 | 0.06 | +0.01 | buy |
| Russell Investments Group, Ltd. | 74,895 | 32,535 | -42,360 | 0.01 | 0.00 | -0.01 | sell |
| StoneX Group Inc. | 32,396 | 32,396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 17,338 | 32,105 | +14,767 | 0.01 | 0.02 | +0.01 | buy |
| NIA IMPACT ADVISORS, LLC | 30,632 | 31,631 | +999 | 1.34 | 0.90 | -0.43 | buy |