| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 3,507,164 | 3,507,164 | 0 | 25.38 | 29.48 | +4.10 | hold |
| Corvex Management LP | 2,473,781 | 3,058,629 | +584,848 | 8.51 | 11.95 | +3.45 | buy |
| LMR Partners LLP | 1,732,805 | 2,035,439 | +302,634 | 0.01 | 0.00 | -0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,188,988 | 1,631,402 | +442,414 | 0.30 | 0.40 | +0.10 | buy |
| BlackRock, Inc. | 1,147,355 | 1,434,634 | +287,279 | 0.00 | 0.00 | +0.00 | buy |
| Pentwater Capital Management LP | 32,000 | 1,220,000 | +1,188,000 | 0.04 | 1.44 | +1.40 | buy |
| VANGUARD GROUP INC | 1,031,326 | 1,180,923 | +149,597 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,089,384 | 1,049,441 | -39,943 | 0.02 | 0.02 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 503,733 | 1,037,116 | +533,383 | 0.03 | 0.06 | +0.03 | buy |
| UBS Group AG | 52,141 | 1,001,720 | +949,579 | 0.00 | 0.02 | +0.02 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 969,954 | 922,454 | -47,500 | 55.93 | 73.69 | +17.76 | sell |
| FRED ALGER MANAGEMENT, LLC | 557,018 | 820,523 | +263,505 | 0.28 | 0.34 | +0.06 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,202,529 | 767,265 | -435,264 | 5.11 | 2.76 | -2.35 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 222,477 | 589,188 | +366,711 | 0.10 | 0.23 | +0.13 | buy |
| Zweig-DiMenna Associates LLC | 457,100 | 586,100 | +129,000 | 6.49 | 5.55 | -0.93 | buy |
| Invesco Ltd. | 389,579 | 554,419 | +164,840 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 212,466 | 487,070 | +274,604 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 392,725 | 484,714 | +91,989 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 467,197 | 467,197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORD, ABBETT & CO. LLC | 409,336 | 434,472 | +25,136 | 0.13 | 0.13 | -0.00 | buy |
| STATE STREET CORP | 339,629 | 415,996 | +76,367 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 333,376 | 413,223 | +79,847 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 425,647 | 406,573 | -19,074 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 6,353 | 397,896 | +391,543 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 436,900 | 386,758 | -50,142 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 222,883 | 337,427 | +114,544 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 303,000 | 326,677 | +23,677 | 0.14 | 0.14 | -0.01 | buy |
| MACQUARIE GROUP LTD | 362,019 | 317,871 | -44,148 | 0.04 | 0.04 | -0.00 | sell |
| Science & Technology Partners, L.P. | 276,641 | 317,276 | +40,635 | 9.71 | 7.67 | -2.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 454,956 | 303,455 | -151,501 | 0.39 | 0.22 | -0.16 | sell |
| CITADEL ADVISORS LLC | 28,396 | 272,227 | +243,831 | 0.00 | 0.02 | +0.02 | buy |
| GAGNON SECURITIES LLC | 284,911 | 271,233 | -13,678 | 5.55 | 5.09 | -0.47 | sell |
| AMERIPRISE FINANCIAL INC | 145,247 | 255,931 | +110,684 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 243,780 | 243,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 235,085 | +235,085 | 0.00 | 0.01 | +0.01 | buy |
| Alamea Verwaltungs GmbH | 211,065 | 223,989 | +12,924 | 16.16 | 15.56 | -0.60 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 417,037 | 221,610 | -195,427 | 3.29 | 1.58 | -1.70 | sell |
| NORTHERN TRUST CORP | 185,189 | 214,984 | +29,795 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 175,000 | +175,000 | 0.00 | 1.87 | +1.87 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 172,383 | +172,383 | 0.00 | 0.12 | +0.12 | buy |
| ASHFORD CAPITAL MANAGEMENT INC | 94,216 | 171,526 | +77,310 | 1.08 | 1.86 | +0.78 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 146,907 | 167,603 | +20,696 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,793,953 | 163,324 | -2,630,629 | 0.02 | 0.00 | -0.01 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 123,500 | 162,900 | +39,400 | 0.55 | 0.65 | +0.11 | buy |
| Portolan Capital Management, LLC | 0 | 162,228 | +162,228 | 0.00 | 0.94 | +0.94 | buy |
| BANK OF AMERICA CORP /DE/ | 60,837 | 156,226 | +95,389 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 136,732 | +136,732 | 0.00 | 0.02 | +0.02 | buy |
| Gagnon Advisors, LLC | 127,062 | 127,062 | 0 | 7.94 | 7.88 | -0.05 | hold |
| DIMENSIONAL FUND ADVISORS LP | 14,924 | 124,753 | +109,829 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 28,358 | 122,749 | +94,391 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 6,819 | 116,727 | +109,908 | 0.00 | 0.01 | +0.01 | buy |
| Q Global Advisors, LLC | 111,701 | 111,701 | 0 | 0.02 | 0.01 | -0.01 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 196,600 | 106,400 | -90,200 | 0.04 | 0.02 | -0.02 | sell |
| TORONTO DOMINION BANK | 0 | 106,250 | +106,250 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.47 | +0.47 | buy |
| Polar Asset Management Partners Inc. | 19,520 | 97,604 | +78,084 | 0.06 | 0.22 | +0.17 | buy |
| ROYCE & ASSOCIATES LP | 31,567 | 93,612 | +62,045 | 0.03 | 0.09 | +0.06 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 71,298 | 93,377 | +22,079 | 0.05 | 0.06 | +0.01 | buy |
| AXA S.A. | 0 | 88,269 | +88,269 | 0.00 | 0.02 | +0.02 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 85,763 | +85,763 | 0.00 | 0.24 | +0.24 | buy |
| Palisades Investment Partners, LLC | 83,913 | 82,975 | -938 | 3.73 | 3.35 | -0.38 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 80,980 | +80,980 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 108,368 | 80,955 | -27,413 | 0.01 | 0.01 | -0.00 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 0 | 80,000 | +80,000 | 0.00 | 1.21 | +1.21 | buy |
| Divisadero Street Capital Management, LP | 73,146 | 73,146 | 0 | 0.74 | 0.45 | -0.29 | hold |
| BOSUN ASSET MANAGEMENT, LLC | 85,776 | 69,858 | -15,918 | 3.64 | 2.31 | -1.33 | sell |
| NORGES BANK | 68,000 | 68,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 43,489 | 66,359 | +22,870 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 62,379 | +62,379 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 61,507 | +61,507 | 0.00 | 1.19 | +1.19 | buy |
| Legal Advantage Investments, Inc. | 50,600 | 60,600 | +10,000 | 2.42 | 2.62 | +0.20 | buy |
| BARCLAYS PLC | 74,880 | 59,405 | -15,475 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 58,044 | +58,044 | 0.00 | 0.09 | +0.09 | buy |
| Ensign Peak Advisors, Inc | 1,500 | 57,242 | +55,742 | 0.00 | 0.01 | +0.01 | buy |
| Simplify Asset Management Inc. | 0 | 56,700 | +56,700 | 0.00 | 0.32 | +0.32 | buy |
| Lisanti Capital Growth, LLC | 29,435 | 56,615 | +27,180 | 0.78 | 1.45 | +0.67 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 85,922 | 55,381 | -30,541 | 0.01 | 0.01 | -0.00 | sell |
| LPL Financial LLC | 43,105 | 54,702 | +11,597 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 286,971 | 52,549 | -234,422 | 0.07 | 0.01 | -0.06 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 28,224 | 48,161 | +19,937 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 106,119 | 47,638 | -58,481 | 0.02 | 0.01 | -0.01 | sell |
| NATIONAL BANK OF CANADA /FI/ | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Calamos Advisors LLC | 57,342 | 44,575 | -12,767 | 0.02 | 0.02 | -0.01 | sell |
| ALGERT GLOBAL LLC | 47,726 | 43,580 | -4,146 | 0.10 | 0.08 | -0.02 | sell |
| Nuveen, LLC | 197,912 | 42,466 | -155,446 | 0.01 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 40,000 | +40,000 | 0.00 | 0.26 | +0.26 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 15,937 | 39,979 | +24,042 | 0.06 | 0.15 | +0.09 | buy |
| Slow Capital, Inc. | 0 | 39,150 | +39,150 | 0.00 | 0.44 | +0.44 | buy |
| Swiss National Bank | 31,900 | 37,500 | +5,600 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 37,340 | 37,340 | 0 | 0.21 | 0.17 | -0.04 | hold |
| TD ASSET MANAGEMENT INC | 16,948 | 35,258 | +18,310 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 34,884 | 34,884 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 29,386 | 34,764 | +5,378 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 48,008 | 34,753 | -13,255 | 0.11 | 0.06 | -0.04 | sell |
| Tri Locum Partners LP | 58,145 | 32,931 | -25,214 | 2.64 | 0.92 | -1.72 | sell |
| COMERICA BANK | 15,388 | 32,569 | +17,181 | 0.01 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 29,479 | 29,190 | -289 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 11,013 | 29,127 | +18,114 | 0.16 | 0.38 | +0.22 | buy |
| PRUDENTIAL FINANCIAL INC | 72,858 | 28,120 | -44,738 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 19,352 | 27,610 | +8,258 | 0.00 | 0.00 | +0.00 | buy |