| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Corvex Management LP | 3,058,629 | 3,058,629 | 0 | 11.95 | 11.80 | -0.15 | hold |
| Casdin Capital, LLC | 3,507,164 | 3,007,164 | -500,000 | 29.48 | 27.01 | -2.47 | sell |
| LMR Partners LLP | 2,035,439 | 2,135,439 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,434,634 | 1,529,075 | +94,441 | 0.00 | 0.00 | +0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,631,402 | 1,220,138 | -411,264 | 0.40 | 0.34 | -0.06 | sell |
| VANGUARD GROUP INC | 1,180,923 | 1,170,422 | -10,501 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,049,441 | 1,168,180 | +118,739 | 0.02 | 0.02 | +0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 922,454 | 889,954 | -32,500 | 73.69 | 66.91 | -6.78 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 767,265 | 823,567 | +56,302 | 2.76 | 2.89 | +0.13 | buy |
| T. Rowe Price Investment Management, Inc. | 1,037,116 | 718,003 | -319,113 | 0.06 | 0.05 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 337,427 | 681,381 | +343,954 | 0.01 | 0.02 | +0.01 | buy |
| Zweig-DiMenna Associates LLC | 586,100 | 602,300 | +16,200 | 5.55 | 5.04 | -0.51 | buy |
| JENNISON ASSOCIATES LLC | 397,896 | 598,426 | +200,530 | 0.02 | 0.04 | +0.02 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 589,188 | 544,094 | -45,094 | 0.23 | 0.25 | +0.02 | sell |
| LORD, ABBETT & CO. LLC | 434,472 | 525,377 | +90,905 | 0.13 | 0.17 | +0.04 | buy |
| FMR LLC | 163,324 | 503,309 | +339,985 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 554,419 | 494,072 | -60,347 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 484,714 | 489,397 | +4,683 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 413,223 | 475,543 | +62,320 | 0.01 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 487,070 | 467,812 | -19,258 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 467,197 | 467,197 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ARK Investment Management LLC | 0 | 446,979 | +446,979 | 0.00 | 0.29 | +0.29 | buy |
| STATE STREET CORP | 415,996 | 439,806 | +23,810 | 0.00 | 0.00 | +0.00 | buy |
| Pentwater Capital Management LP | 1,220,000 | 425,000 | -795,000 | 1.44 | 0.41 | -1.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 303,455 | 410,030 | +106,575 | 0.22 | 0.32 | +0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 406,573 | 395,731 | -10,842 | 0.01 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 386,758 | 360,063 | -26,695 | 0.01 | 0.01 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 820,523 | 357,302 | -463,221 | 0.34 | 0.15 | -0.19 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,055 | 331,408 | +316,353 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 292,255 | +292,255 | 0.00 | 0.02 | +0.02 | buy |
| Nikko Asset Management Americas, Inc. | 0 | 292,255 | +292,255 | 0.00 | 0.30 | +0.30 | buy |
| GAGNON SECURITIES LLC | 271,233 | 269,066 | -2,167 | 5.09 | 5.82 | +0.73 | sell |
| MACQUARIE GROUP LTD | 317,871 | 269,040 | -48,831 | 0.04 | 0.03 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 243,780 | 243,780 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEXT CENTURY GROWTH INVESTORS LLC | 221,610 | 234,109 | +12,499 | 1.58 | 1.84 | +0.26 | buy |
| Science & Technology Partners, L.P. | 317,276 | 224,073 | -93,203 | 7.67 | 6.85 | -0.82 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 235,085 | 209,255 | -25,830 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 214,984 | 206,461 | -8,523 | 0.00 | 0.00 | +0.00 | sell |
| Alamea Verwaltungs GmbH | 223,989 | 195,988 | -28,001 | 15.56 | 14.43 | -1.13 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 162,900 | 193,920 | +31,020 | 0.65 | 0.80 | +0.15 | buy |
| CITADEL ADVISORS LLC | 272,227 | 190,940 | -81,287 | 0.02 | 0.02 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 255,931 | 183,067 | -72,864 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 167,603 | 176,503 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 156,226 | 164,545 | +8,319 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 66,359 | 162,749 | +96,390 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,001,720 | 149,789 | -851,931 | 0.02 | 0.00 | -0.02 | sell |
| ASHFORD CAPITAL MANAGEMENT INC | 171,526 | 132,456 | -39,070 | 1.86 | 1.59 | -0.27 | sell |
| TWO SIGMA INVESTMENTS, LP | 122,749 | 130,433 | +7,684 | 0.02 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 124,753 | 128,382 | +3,629 | 0.00 | 0.00 | +0.00 | buy |
| Gagnon Advisors, LLC | 127,062 | 127,062 | 0 | 7.88 | 8.45 | +0.57 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,906 | 124,538 | +99,632 | 0.00 | 0.02 | +0.02 | buy |
| Telemark Asset Management, LLC | 0 | 120,000 | +120,000 | 0.00 | 1.23 | +1.23 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 116,727 | 117,696 | +969 | 0.01 | 0.01 | +0.00 | buy |
| Q Global Advisors, LLC | 111,701 | 111,701 | 0 | 0.01 | 0.02 | +0.01 | hold |
| TORONTO DOMINION BANK | 106,250 | 106,050 | -200 | 0.00 | 0.00 | +0.00 | sell |
| ROYCE & ASSOCIATES LP | 93,612 | 103,199 | +9,587 | 0.09 | 0.11 | +0.02 | buy |
| Capital International Investors | 0 | 100,284 | +100,284 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.47 | 0.41 | -0.05 | hold |
| Jump Financial, LLC | 9,900 | 92,548 | +82,648 | 0.01 | 0.15 | +0.14 | buy |
| JANE STREET GROUP, LLC | 0 | 92,292 | +92,292 | 0.00 | 0.01 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 106,400 | 90,500 | -15,900 | 0.02 | 0.02 | -0.00 | sell |
| Palisades Investment Partners, LLC | 82,975 | 84,743 | +1,768 | 3.35 | 3.58 | +0.24 | buy |
| Ensign Peak Advisors, Inc | 57,242 | 78,981 | +21,739 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 80,955 | 78,947 | -2,008 | 0.01 | 0.01 | +0.00 | sell |
| Squarepoint Ops LLC | 12,617 | 77,845 | +65,228 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 24,785 | 76,132 | +51,347 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 85,763 | 74,247 | -11,516 | 0.24 | 0.24 | +0.00 | sell |
| Divisadero Street Capital Management, LP | 73,146 | 73,146 | 0 | 0.45 | 0.37 | -0.09 | hold |
| StoneX Group Inc. | 0 | 71,959 | +71,959 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 71,786 | +71,786 | 0.00 | 0.22 | +0.22 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 68,654 | +68,654 | 0.00 | 0.05 | +0.05 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 80,980 | 68,169 | -12,811 | 0.02 | 0.02 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 62,379 | 64,101 | +1,722 | 0.00 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 93,377 | 61,790 | -31,587 | 0.06 | 0.04 | -0.01 | sell |
| Legal Advantage Investments, Inc. | 60,600 | 60,650 | +50 | 2.62 | 2.94 | +0.33 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 80,000 | 60,000 | -20,000 | 1.21 | 0.99 | -0.22 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 13,539 | 59,624 | +46,085 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 58,044 | 58,044 | 0 | 0.09 | 0.08 | -0.01 | hold |
| Lisanti Capital Growth, LLC | 56,615 | 56,623 | +8 | 1.45 | 1.49 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 55,381 | 55,453 | +72 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 42,466 | 54,064 | +11,598 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 51,738 | +51,738 | 0.00 | 0.00 | +0.00 | buy |
| Impax Asset Management Group plc | 0 | 50,000 | +50,000 | 0.00 | 0.03 | +0.03 | buy |
| Calamos Advisors LLC | 44,575 | 46,930 | +2,355 | 0.02 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 59,405 | 45,980 | -13,425 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 175,000 | 45,250 | -129,750 | 1.87 | 0.54 | -1.33 | sell |
| Portolan Capital Management, LLC | 162,228 | 44,048 | -118,180 | 0.94 | 0.26 | -0.68 | sell |
| Slow Capital, Inc. | 39,150 | 39,020 | -130 | 0.44 | 0.49 | +0.05 | sell |
| RBF Capital, LLC | 37,340 | 37,340 | 0 | 0.17 | 0.18 | +0.01 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 18,875 | 36,811 | +17,936 | 0.00 | 0.01 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 29,127 | 36,505 | +7,378 | 0.38 | 0.51 | +0.13 | buy |
| Swiss National Bank | 37,500 | 35,900 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 34,764 | 35,368 | +604 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 34,884 | 34,884 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Trexquant Investment LP | 0 | 34,474 | +34,474 | 0.00 | 0.04 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 35,258 | 33,432 | -1,826 | 0.00 | 0.00 | +0.00 | sell |
| NIA IMPACT ADVISORS, LLC | 17,123 | 31,875 | +14,752 | 0.55 | 1.12 | +0.57 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 48,161 | 31,657 | -16,504 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 32,569 | 30,518 | -2,051 | 0.01 | 0.01 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 14,274 | 28,926 | +14,652 | 0.00 | 0.00 | +0.00 | buy |