| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 1,408,152 | 1,922,093 | +513,941 | 1.97 | 2.60 | +0.63 | buy |
| Orbis Allan Gray Ltd | 6,762,231 | 7,006,542 | +244,311 | 0.52 | 0.53 | +0.02 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 78,765 | 305,794 | +227,029 | 0.03 | 0.10 | +0.07 | buy |
| TFG Asset Management GP Ltd | 258,132 | 356,657 | +98,525 | 0.91 | 1.25 | +0.34 | buy |
| Artisan Partners Limited Partnership | 619,457 | 659,786 | +40,329 | 0.02 | 0.02 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 160,594 | 199,594 | +39,000 | 0.46 | 0.58 | +0.12 | buy |
| Sofinnova Investments, Inc. | 1,633,897 | 1,658,384 | +24,487 | 1.13 | 1.90 | +0.78 | buy |
| Aegis Wealth Management LLC | 135,030 | 150,030 | +15,000 | 1.40 | 1.57 | +0.17 | buy |
| Clearbridge Investments, LLC | 403,225 | 415,131 | +11,906 | 0.01 | 0.01 | +0.00 | buy |
| Darwin Wealth Management, LLC | 154,862 | 155,270 | +408 | 0.87 | 0.58 | -0.29 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 4,150 | 4,250 | +100 | 0.04 | 0.05 | +0.01 | buy |
| Aspect Partners, LLC | 225 | 233 | +8 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 196,188 | 194,643 | -1,545 | 0.11 | 0.11 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 29,219 | 26,310 | -2,909 | 0.04 | 0.03 | -0.01 | sell |
| HighVista Strategies LLC | 182,929 | 171,961 | -10,968 | 0.92 | 0.87 | -0.04 | sell |
| Rock Springs Capital Management LP | 972,198 | 942,154 | -30,044 | 1.04 | 1.02 | -0.02 | sell |
| ARMISTICE CAPITAL, LLC | 3,175,110 | 3,087,226 | -87,884 | 1.02 | 0.84 | -0.18 | sell |
| SAMLYN CAPITAL, LLC | 1,922,543 | 1,754,708 | -167,835 | 0.59 | 0.63 | +0.04 | sell |
| University of Wisconsin Foundation | 484,745 | 313,559 | -171,186 | 7.80 | 5.51 | -2.29 | sell |
| ArrowMark Colorado Holdings LLC | 673,949 | 397,221 | -276,728 | 0.32 | 0.37 | +0.04 | sell |
| Fiera Capital Corp | 1,380,620 | 789,989 | -590,631 | 0.09 | 0.06 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 4,668,839 | 2,689,235 | -1,979,604 | 1.65 | 0.90 | -0.76 | sell |