| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,908,980 | 11,207,000 | +2,298,020 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,328,373 | 3,936,806 | +1,608,433 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 83,147 | 1,488,917 | +1,405,770 | 0.00 | 0.03 | +0.03 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,202,203 | +1,202,203 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 1,400,000 | 2,550,000 | +1,150,000 | 1.31 | 2.44 | +1.13 | buy |
| DIMENSIONAL FUND ADVISORS LP | 951,589 | 1,946,479 | +994,890 | 0.00 | 0.01 | +0.00 | buy |
| Novo Holdings A/S | 0 | 960,394 | +960,394 | 0.00 | 1.24 | +1.24 | buy |
| CITADEL ADVISORS LLC | 201,144 | 1,143,958 | +942,814 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 6,653,746 | 7,458,263 | +804,517 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,443,313 | 2,233,398 | +790,085 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 11,699,870 | 12,404,330 | +704,460 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,408,152 | 1,922,093 | +513,941 | 1.97 | 2.60 | +0.63 | buy |
| GOLDMAN SACHS GROUP INC | 1,723,116 | 2,157,195 | +434,079 | 0.00 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 338,565 | +338,565 | 0.00 | 0.27 | +0.27 | buy |
| ORBIMED ADVISORS LLC | 2,917,884 | 3,235,684 | +317,800 | 1.15 | 1.36 | +0.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 158,548 | 431,850 | +273,302 | 0.00 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 245,278 | +245,278 | 0.00 | 0.01 | +0.01 | buy |
| Orbis Allan Gray Ltd | 6,762,231 | 7,006,542 | +244,311 | 0.52 | 0.53 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,504,114 | 3,743,427 | +239,313 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 78,765 | 305,794 | +227,029 | 0.05 | 0.15 | +0.10 | buy |
| ALPS ADVISORS INC | 0 | 167,082 | +167,082 | 0.00 | 0.02 | +0.02 | buy |
| AXXCESS WEALTH MANAGEMENT, LLC | 0 | 155,270 | +155,270 | 0.00 | 0.05 | +0.05 | buy |
| CITIGROUP INC | 37,797 | 187,915 | +150,118 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 162,972 | 298,317 | +135,345 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 134,752 | +134,752 | 0.00 | 0.02 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 30,785,801 | 30,912,287 | +126,486 | 0.38 | 0.45 | +0.07 | buy |
| RAYMOND JAMES FINANCIAL INC | 451,644 | 576,350 | +124,706 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 116,341 | +116,341 | 0.00 | 0.03 | +0.03 | buy |
| Aberdeen Group plc | 1,430,384 | 1,539,434 | +109,050 | 0.04 | 0.05 | +0.01 | buy |
| TFG Asset Management GP Ltd | 258,132 | 356,657 | +98,525 | 0.92 | 1.29 | +0.37 | buy |
| Y-Intercept (Hong Kong) Ltd | 65,158 | 156,203 | +91,045 | 0.02 | 0.07 | +0.05 | buy |
| Saturn V Capital Management LP | 966,609 | 1,057,493 | +90,884 | 3.17 | 3.37 | +0.19 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 86,609 | 174,457 | +87,848 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 42,710 | 125,786 | +83,076 | 0.01 | 0.04 | +0.02 | buy |
| NORTHERN TRUST CORP | 1,198,838 | 1,278,081 | +79,243 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 145,509 | 220,664 | +75,155 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 40,036 | 105,417 | +65,381 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 380,561 | 443,284 | +62,723 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 60,161 | +60,161 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 53,200 | +53,200 | 0.00 | 0.00 | +0.00 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 0 | 52,975 | +52,975 | 0.00 | 0.01 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 821,849 | 874,138 | +52,289 | 0.15 | 0.18 | +0.03 | buy |
| ALGERT GLOBAL LLC | 454,463 | 506,273 | +51,810 | 0.12 | 0.13 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| NORGES BANK | 0 | 49,319 | +49,319 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,158,390 | 1,202,203 | +43,813 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 619,457 | 659,786 | +40,329 | 0.02 | 0.02 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 160,594 | 199,594 | +39,000 | 0.50 | 0.63 | +0.13 | buy |
| ALLIANCEBERNSTEIN L.P. | 135,940 | 172,080 | +36,140 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 19,297 | 51,489 | +32,192 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 239,285 | 269,985 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 30,600 | +30,600 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 1,633,897 | 1,658,384 | +24,487 | 1.48 | 1.97 | +0.48 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 333,497 | 355,953 | +22,456 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,009,082 | 2,030,819 | +21,737 | 0.01 | 0.01 | +0.00 | buy |
| FIFTH THIRD BANCORP | 54,229 | 75,859 | +21,630 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 21,538 | +21,538 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 221,123 | 242,392 | +21,269 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 24,078 | 43,097 | +19,019 | 0.03 | 0.09 | +0.05 | buy |
| TD ASSET MANAGEMENT INC | 529,312 | 548,112 | +18,800 | 0.01 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 0 | 15,700 | +15,700 | 0.00 | 0.01 | +0.01 | buy |
| Aegis Wealth Management LLC | 135,030 | 150,030 | +15,000 | 1.40 | 1.57 | +0.17 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,850 | 78,622 | +14,772 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 14,178 | +14,178 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 13,522 | +13,522 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 403,225 | 415,131 | +11,906 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 15,000 | 26,700 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 24,023 | 35,537 | +11,514 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,015 | +10,015 | 0.00 | 0.02 | +0.02 | buy |
| Janney Montgomery Scott LLC | 0 | 9,762 | +9,762 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 9,429 | +9,429 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 401,616 | 409,801 | +8,185 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 72,841 | 79,775 | +6,934 | 0.01 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52,152 | 58,947 | +6,795 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 69,215 | 75,783 | +6,568 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 6,561 | +6,561 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 5,569 | +5,569 | 0.00 | 0.04 | +0.04 | buy |
| Creative Planning | 29,945 | 34,857 | +4,912 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 36,304 | 40,235 | +3,931 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 228,100 | 232,000 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 14,150 | 17,988 | +3,838 | 0.07 | 0.09 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 48,882 | 52,427 | +3,545 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,922 | +1,922 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 20,575 | 22,480 | +1,905 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 18,364 | 20,058 | +1,694 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 52,980 | 54,498 | +1,518 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 96,462 | 97,940 | +1,478 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 10,907 | 12,381 | +1,474 | 0.01 | 0.01 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 1,268 | +1,268 | 0.00 | 0.01 | +0.01 | buy |
| XPONANCE, INC. | 12,208 | 13,436 | +1,228 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,571 | 69,702 | +1,131 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 997 | +997 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 804 | +804 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 747 | +747 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 75,469 | 76,195 | +726 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 683 | +683 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 36,569 | 37,180 | +611 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 2,328 | 2,787 | +459 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 4,480 | 4,928 | +448 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,972 | 3,387 | +415 | 0.00 | 0.00 | +0.00 | buy |