| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Atlas Venture Life Science Advisors, LLC | 9,885,449 | 8,020,136 | -1,865,313 | 15.66 | 21.01 | +5.36 | sell |
| FCPM III SERVICES B.V. | 6,131,079 | 7,845,364 | +1,714,285 | 24.03 | 31.49 | +7.46 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,954,779 | +4,954,779 | 0.00 | 1.79 | +1.79 | buy |
| Deep Track Capital, LP | 2,000,000 | 4,555,383 | +2,555,383 | 0.93 | 3.72 | +2.79 | buy |
| CITADEL ADVISORS LLC | 3,053,440 | 4,254,276 | +1,200,836 | 0.04 | 0.12 | +0.08 | buy |
| STATE STREET CORP | 2,337,141 | 4,193,553 | +1,856,412 | 0.00 | 0.01 | +0.00 | buy |
| MPM ASSET MANAGEMENT LLC | 4,951,303 | 3,451,303 | -1,500,000 | 32.36 | 39.97 | +7.61 | sell |
| VANGUARD GROUP INC | 2,329,641 | 3,440,270 | +1,110,629 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,282,812 | 3,218,393 | +1,935,581 | 0.00 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 3,091,587 | +3,091,587 | 0.00 | 1.30 | +1.30 | buy |
| JANUS HENDERSON GROUP PLC | 11,330 | 2,675,240 | +2,663,910 | 0.00 | 0.04 | +0.04 | buy |
| TCG Crossover Management, LLC | 1,650,150 | 2,650,150 | +1,000,000 | 2.43 | 5.95 | +3.51 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,325,000 | +2,325,000 | 0.00 | 0.12 | +0.12 | buy |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 1.98 | 2.94 | +0.95 | hold |
| Sofinnova Investments, Inc. | 1,013,505 | 1,936,650 | +923,145 | 0.76 | 3.24 | +2.49 | buy |
| FRANKLIN RESOURCES INC | 1,913,832 | 1,783,271 | -130,561 | 0.01 | 0.02 | +0.00 | sell |
| Logos Global Management LP | 1,880,000 | 1,730,000 | -150,000 | 2.78 | 5.17 | +2.39 | sell |
| GOLDMAN SACHS GROUP INC | 1,160,772 | 1,661,088 | +500,316 | 0.00 | 0.01 | +0.01 | buy |
| Vivo Capital, LLC | 1,035,136 | 1,635,136 | +600,000 | 1.13 | 3.65 | +2.52 | buy |
| Artal Group S.A. | 1,217,960 | 1,517,960 | +300,000 | 0.55 | 1.11 | +0.56 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 932,838 | 1,307,604 | +374,766 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 792,945 | 1,242,945 | +450,000 | 1.69 | 4.29 | +2.60 | buy |
| JENNISON ASSOCIATES LLC | 202,871 | 1,207,551 | +1,004,680 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,502 | 1,132,092 | +1,118,590 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 375,000 | 1,100,224 | +725,224 | 0.01 | 0.07 | +0.06 | buy |
| ARMISTICE CAPITAL, LLC | 824,000 | 1,000,000 | +176,000 | 0.29 | 0.76 | +0.46 | buy |
| MORGAN STANLEY | 2,021,395 | 962,164 | -1,059,231 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 708,400 | +708,400 | 0.00 | 0.37 | +0.37 | buy |
| Woodline Partners LP | 435,526 | 697,927 | +262,401 | 0.06 | 0.18 | +0.12 | buy |
| Point72 Asset Management, L.P. | 389,200 | 686,434 | +297,234 | 0.02 | 0.06 | +0.04 | buy |
| Candriam S.C.A. | 763,624 | 675,624 | -88,000 | 0.07 | 0.12 | +0.05 | sell |
| Ensign Peak Advisors, Inc | 511,293 | 611,293 | +100,000 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 423,085 | 547,035 | +123,950 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 331,568 | 461,522 | +129,954 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 451,824 | +451,824 | 0.00 | 0.33 | +0.33 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,018 | 440,534 | +414,516 | 0.00 | 0.02 | +0.02 | buy |
| Nantahala Capital Management, LLC | 642,789 | 435,256 | -207,533 | 0.86 | 1.21 | +0.35 | sell |
| EcoR1 Capital, LLC | 0 | 427,039 | +427,039 | 0.00 | 0.31 | +0.31 | buy |
| WASATCH ADVISORS LP | 1,684,517 | 417,794 | -1,266,723 | 0.12 | 0.06 | -0.06 | sell |
| Vida Ventures Advisors, LLC | 2,074,787 | 407,499 | -1,667,288 | 32.85 | 6.43 | -26.42 | sell |
| ArrowMark Colorado Holdings LLC | 382,416 | 382,416 | 0 | 0.06 | 0.12 | +0.07 | hold |
| Rafferty Asset Management, LLC | 164,041 | 344,391 | +180,350 | 0.01 | 0.04 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 805,551 | 326,629 | -478,922 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 71,604 | 300,127 | +228,523 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 285,000 | +285,000 | 0.00 | 0.10 | +0.10 | buy |
| AXA S.A. | 550,324 | 278,566 | -271,758 | 0.02 | 0.02 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 275,699 | 269,757 | -5,942 | 0.03 | 0.06 | +0.03 | sell |
| Invesco Ltd. | 75,172 | 250,040 | +174,868 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 145,474 | 235,288 | +89,814 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 124,050 | 233,327 | +109,277 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 170,560 | 204,271 | +33,711 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 147,836 | 184,500 | +36,664 | 1.11 | 3.40 | +2.30 | buy |
| Atika Capital Management LLC | 0 | 175,000 | +175,000 | 0.00 | 0.56 | +0.56 | buy |
| Monashee Investment Management LLC | 0 | 170,000 | +170,000 | 0.00 | 0.57 | +0.57 | buy |
| ALLIANCEBERNSTEIN L.P. | 280,114 | 168,351 | -111,763 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 40,782 | 152,632 | +111,850 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 147,968 | +147,968 | 0.00 | 0.65 | +0.65 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 145,160 | +145,160 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137,751 | 137,751 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Artia Global Partners LP | 0 | 119,488 | +119,488 | 0.00 | 0.83 | +0.83 | buy |
| First Light Asset Management, LLC | 0 | 105,948 | +105,948 | 0.00 | 0.23 | +0.23 | buy |
| Russell Investments Group, Ltd. | 100,496 | 101,943 | +1,447 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 53,344 | 100,656 | +47,312 | 0.00 | 0.01 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 99,822 | +99,822 | 0.00 | 1.87 | +1.87 | buy |
| RHUMBLINE ADVISERS | 76,238 | 98,329 | +22,091 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 18,483 | 87,523 | +69,040 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 0 | 86,610 | +86,610 | 0.00 | 0.60 | +0.60 | buy |
| Swiss National Bank | 60,200 | 85,200 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 153,351 | 83,972 | -69,379 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 0 | 79,180 | +79,180 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 38,782 | 76,934 | +38,152 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.20 | +0.20 | buy |
| TD ASSET MANAGEMENT INC | 0 | 74,800 | +74,800 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,329 | 64,342 | +47,013 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 40,000 | 60,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 56,961 | +56,961 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 41,483 | 54,370 | +12,887 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 53,705 | +53,705 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 26,962 | 53,447 | +26,485 | 0.02 | 0.06 | +0.04 | buy |
| SIMPLEX TRADING, LLC | 18,061 | 49,706 | +31,645 | 0.01 | 0.04 | +0.03 | buy |
| NORGES BANK | 0 | 47,258 | +47,258 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,467 | 44,784 | +10,317 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 24,274 | 44,101 | +19,827 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 42,817 | +42,817 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,461 | 40,316 | +19,855 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 22,822 | 38,979 | +16,157 | 0.01 | 0.02 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 18,500 | 37,768 | +19,268 | 0.02 | 0.09 | +0.07 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 57,330 | 33,125 | -24,205 | 0.02 | 0.03 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 0 | 32,410 | +32,410 | 0.00 | 0.00 | +0.00 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 0 | 31,325 | +31,325 | 0.00 | 0.16 | +0.16 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 25,389 | 31,281 | +5,892 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 22,933 | 30,482 | +7,549 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 22,111 | 29,138 | +7,027 | 0.00 | 0.00 | +0.00 | buy |
| Ratan Capital Management LP | 0 | 29,000 | +29,000 | 0.00 | 0.44 | +0.44 | buy |
| Mirae Asset Global Investments Co., Ltd. | 22,921 | 28,617 | +5,696 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 28,529 | +28,529 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 161,004 | 27,423 | -133,581 | 0.09 | 0.03 | -0.06 | sell |
| Jump Financial, LLC | 0 | 27,382 | +27,382 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 20,901 | 27,078 | +6,177 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 0 | 25,500 | +25,500 | 0.00 | 0.02 | +0.02 | buy |