| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,381,144 | 9,714,392 | +3,333,248 | 2.00 | 1.70 | -0.30 | buy |
| JANUS HENDERSON GROUP PLC | 7,379,309 | 10,353,416 | +2,974,107 | 0.09 | 0.07 | 0.00 | buy |
| BRAIDWELL LP | 681,182 | 3,621,344 | +2,940,162 | 0.48 | 1.33 | +0.86 | buy |
| ARMISTICE CAPITAL, LLC | 964,518 | 2,768,000 | +1,803,482 | 0.31 | 0.43 | +0.12 | buy |
| PERCEPTIVE ADVISORS LLC | 543,277 | 2,313,403 | +1,770,126 | 0.35 | 0.85 | +0.50 | buy |
| Siren, L.L.C. | 1,347,456 | 2,717,987 | +1,370,531 | 1.40 | 1.60 | +0.20 | buy |
| Atlas Venture Life Science Advisors, LLC | 8,019,354 | 9,130,465 | +1,111,111 | 23.05 | 18.30 | -4.75 | buy |
| ALGERT GLOBAL LLC | 80,923 | 476,007 | +395,084 | 0.05 | 0.12 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 435,653 | 812,408 | +376,755 | 0.19 | 0.17 | -0.03 | buy |
| Integral Health Asset Management, LLC | 150,000 | 450,000 | +300,000 | 0.31 | 0.52 | +0.21 | buy |
| Aberdeen Group plc | 25,803 | 314,586 | +288,783 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 320,626 | 511,048 | +190,422 | 0.04 | 0.03 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 147,002 | 242,825 | +95,823 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 236,262 | 329,262 | +93,000 | 1.01 | 0.79 | -0.21 | buy |
| Candriam S.C.A. | 401,395 | 463,368 | +61,973 | 0.05 | 0.03 | -0.02 | buy |
| Logos Global Management LP | 450,000 | 500,000 | +50,000 | 1.24 | 0.93 | -0.31 | buy |
| Rock Springs Capital Management LP | 474,528 | 524,499 | +49,971 | 0.43 | 0.31 | -0.11 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 12,584 | 21,422 | +8,838 | 0.02 | 0.02 | 0.00 | buy |
| Privium Fund Management B.V. | 20,366 | 27,566 | +7,200 | 0.11 | 0.08 | -0.03 | buy |
| E Fund Management Co., Ltd. | 11,848 | 13,771 | +1,923 | 0.01 | 0.01 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 21,575 | 22,690 | +1,115 | 0.05 | 0.02 | -0.03 | buy |
| Woodline Partners LP | 573,957 | 574,435 | +478 | 0.09 | 0.04 | -0.05 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,137 | 2,605 | +468 | 0.00 | 0.00 | -0.00 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 44,940 | 44,865 | -75 | 0.17 | 0.08 | -0.08 | sell |
| Aspect Partners, LLC | 725 | 25 | -700 | 0.01 | 0.00 | -0.01 | sell |
| PROFUND ADVISORS LLC | 32,594 | 30,719 | -1,875 | 0.03 | 0.01 | -0.01 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 298,052 | 289,603 | -8,449 | 0.07 | 0.03 | -0.03 | sell |
| Rafferty Asset Management, LLC | 167,482 | 147,353 | -20,129 | 0.01 | 0.01 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 932,231 | 897,946 | -34,285 | 0.30 | 0.15 | -0.14 | sell |
| Ratan Capital Management LP | 230,900 | 98,900 | -132,000 | 0.83 | 0.33 | -0.50 | sell |
| ORBIMED ADVISORS LLC | 1,227,080 | 1,014,611 | -212,469 | 0.60 | 0.25 | -0.35 | sell |
| Sofinnova Investments, Inc. | 1,071,498 | 716,896 | -354,602 | 1.84 | 0.49 | -1.35 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,402,452 | 1,820,415 | -582,037 | 0.01 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 5,218,641 | 1,690,567 | -3,528,074 | 1.86 | 0.27 | -1.59 | sell |