| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,381,144 | 9,714,392 | +3,333,248 | 2.00 | 1.70 | -0.30 | buy |
| JANUS HENDERSON GROUP PLC | 7,379,309 | 10,353,416 | +2,974,107 | 0.09 | 0.06 | -0.02 | buy |
| BRAIDWELL LP | 681,182 | 3,621,344 | +2,940,162 | 0.48 | 1.33 | +0.86 | buy |
| JPMORGAN CHASE & CO | 98,387 | 2,531,313 | +2,432,926 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 964,518 | 2,768,000 | +1,803,482 | 0.53 | 0.77 | +0.25 | buy |
| Vestal Point Capital, LP | 0 | 1,800,000 | +1,800,000 | 0.00 | 1.34 | +1.34 | buy |
| PERCEPTIVE ADVISORS LLC | 543,277 | 2,313,403 | +1,770,126 | 0.36 | 0.86 | +0.50 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,443,341 | +1,443,341 | 0.00 | 0.69 | +0.69 | buy |
| Siren, L.L.C. | 1,347,456 | 2,717,987 | +1,370,531 | 1.40 | 1.60 | +0.20 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 119,015 | 1,388,425 | +1,269,410 | 0.01 | 0.05 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,167,975 | +1,167,975 | 0.00 | 0.01 | +0.01 | buy |
| Atlas Venture Life Science Advisors, LLC | 8,019,354 | 9,130,465 | +1,111,111 | 23.05 | 18.30 | -4.75 | buy |
| VANGUARD GROUP INC | 6,703,926 | 7,406,344 | +702,418 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 753,593 | 1,391,587 | +637,994 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 924,681 | 1,528,534 | +603,853 | 0.06 | 0.04 | -0.01 | buy |
| Qube Research & Technologies Ltd | 267,377 | 680,836 | +413,459 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 19,036 | 430,051 | +411,015 | 0.00 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 80,923 | 476,007 | +395,084 | 0.04 | 0.12 | +0.08 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 435,653 | 812,408 | +376,755 | 0.20 | 0.17 | -0.03 | buy |
| GOLDMAN SACHS GROUP INC | 628,703 | 994,886 | +366,183 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 0 | 358,837 | +358,837 | 0.00 | 1.22 | +1.22 | buy |
| Nantahala Capital Management, LLC | 0 | 345,062 | +345,062 | 0.00 | 0.30 | +0.30 | buy |
| Palo Alto Investors LP | 0 | 333,391 | +333,391 | 0.00 | 0.66 | +0.66 | buy |
| Integral Health Asset Management, LLC | 150,000 | 450,000 | +300,000 | 0.31 | 0.52 | +0.21 | buy |
| Aberdeen Group plc | 25,803 | 314,586 | +288,783 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 258,391 | +258,391 | 0.00 | 2.42 | +2.42 | buy |
| DEUTSCHE BANK AG\ | 70,961 | 317,664 | +246,703 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 224,176 | +224,176 | 0.00 | 0.17 | +0.17 | buy |
| Trexquant Investment LP | 125,378 | 334,443 | +209,065 | 0.03 | 0.04 | +0.01 | buy |
| WASATCH ADVISORS LP | 320,626 | 511,048 | +190,422 | 0.04 | 0.03 | -0.01 | buy |
| Walleye Capital LLC | 0 | 154,634 | +154,634 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 133,772 | 287,653 | +153,881 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,861,581 | 3,009,389 | +147,808 | 0.06 | 0.03 | -0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 122,641 | 269,976 | +147,335 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 146,294 | +146,294 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 118,869 | +118,869 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 115,078 | +115,078 | 0.00 | 0.04 | +0.04 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 108,374 | +108,374 | 0.00 | 0.05 | +0.05 | buy |
| Casdin Capital, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.09 | +0.09 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 98,597 | +98,597 | 0.00 | 0.09 | +0.09 | buy |
| BlackRock, Inc. | 7,949,402 | 8,046,938 | +97,536 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 147,002 | 242,825 | +95,823 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 236,262 | 329,262 | +93,000 | 1.03 | 0.85 | -0.18 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 92,652 | +92,652 | 0.00 | 0.10 | +0.10 | buy |
| FRANKLIN RESOURCES INC | 1,323,803 | 1,414,835 | +91,032 | 0.01 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 84,918 | +84,918 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 84,430 | +84,430 | 0.00 | 0.28 | +0.28 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 66,998 | 147,365 | +80,367 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,514 | 154,354 | +74,840 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 9,768 | 80,665 | +70,897 | 0.02 | 0.06 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,887,329 | 1,955,505 | +68,176 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 188,651 | 251,817 | +63,166 | 0.01 | 0.01 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 62,269 | +62,269 | 0.00 | 0.02 | +0.02 | buy |
| Candriam S.C.A. | 401,395 | 463,368 | +61,973 | 0.05 | 0.03 | -0.02 | buy |
| Voleon Capital Management LP | 0 | 59,673 | +59,673 | 0.00 | 0.05 | +0.05 | buy |
| TWINBEECH CAPITAL LP | 0 | 58,525 | +58,525 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 142,917 | 194,955 | +52,038 | 0.00 | 0.00 | -0.00 | buy |
| Logos Global Management LP | 450,000 | 500,000 | +50,000 | 1.24 | 0.93 | -0.31 | buy |
| Rock Springs Capital Management LP | 474,528 | 524,499 | +49,971 | 0.43 | 0.31 | -0.11 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 33,976 | 77,351 | +43,375 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 37,536 | 78,179 | +40,643 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 192,239 | 231,224 | +38,985 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 43,264 | 81,266 | +38,002 | 0.01 | 0.01 | -0.00 | buy |
| Aegis Wealth Management LLC | 0 | 33,228 | +33,228 | 0.00 | 0.20 | +0.20 | buy |
| XTX Topco Ltd | 0 | 31,574 | +31,574 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 0 | 30,099 | +30,099 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 40,323 | 66,293 | +25,970 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 23,560 | +23,560 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 17,834 | +17,834 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 17,805 | +17,805 | 0.00 | 0.05 | +0.05 | buy |
| GUGGENHEIM CAPITAL LLC | 26,018 | 43,680 | +17,662 | 0.01 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 17,088 | +17,088 | 0.00 | 0.03 | +0.03 | buy |
| Bayesian Capital Management, LP | 0 | 16,400 | +16,400 | 0.00 | 0.03 | +0.03 | buy |
| AlphaQuest LLC | 0 | 16,332 | +16,332 | 0.00 | 0.02 | +0.02 | buy |
| Bridgefront Capital, LLC | 0 | 15,540 | +15,540 | 0.00 | 0.05 | +0.05 | buy |
| HSBC HOLDINGS PLC | 13,354 | 28,396 | +15,042 | 0.00 | 0.00 | -0.00 | buy |
| Optimize Financial Inc | 0 | 14,761 | +14,761 | 0.00 | 0.06 | +0.06 | buy |
| Mariner, LLC | 11,157 | 25,652 | +14,495 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 143,363 | 157,791 | +14,428 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 153,218 | 167,625 | +14,407 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 11,744 | +11,744 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 108,600 | 118,300 | +9,700 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 12,584 | 21,422 | +8,838 | 0.01 | 0.01 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 8,795 | +8,795 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 20,366 | 27,566 | +7,200 | 0.11 | 0.08 | -0.03 | buy |
| Virtus Investment Advisers, LLC | 0 | 6,413 | +6,413 | 0.00 | 0.02 | +0.02 | buy |
| COMERICA BANK | 35,409 | 41,176 | +5,767 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 128,244 | 133,627 | +5,383 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 16,722 | 21,345 | +4,623 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 4,500 | +4,500 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,751 | 19,247 | +3,496 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 613 | 3,526 | +2,913 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,580 | 56,466 | +2,886 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 646 | 3,092 | +2,446 | 0.01 | 0.02 | +0.01 | buy |
| Aster Capital Management (DIFC) Ltd | 18 | 2,252 | +2,234 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 11,848 | 13,771 | +1,923 | 0.01 | 0.01 | -0.01 | buy |
| Arizona State Retirement System | 16,020 | 17,501 | +1,481 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,754 | 40,158 | +1,404 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 1,199 | +1,199 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,575 | 22,690 | +1,115 | 0.05 | 0.02 | -0.03 | buy |