| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 17,540,089 | 30,785,801 | +13,245,712 | 0.22 | 0.38 | +0.17 | buy |
| Orbis Allan Gray Ltd | 4,801,928 | 6,762,231 | +1,960,303 | 0.39 | 0.52 | +0.12 | buy |
| PERCEPTIVE ADVISORS LLC | 3,478,944 | 4,668,839 | +1,189,895 | 1.25 | 1.67 | +0.43 | buy |
| SAMLYN CAPITAL, LLC | 1,493,075 | 1,922,543 | +429,468 | 0.47 | 0.60 | +0.13 | buy |
| Aberdeen Group plc | 1,108,145 | 1,430,384 | +322,239 | 0.03 | 0.04 | +0.01 | buy |
| Palo Alto Investors LP | 1,472,197 | 1,652,972 | +180,775 | 4.01 | 4.58 | +0.57 | buy |
| Logos Global Management LP | 1,250,000 | 1,400,000 | +150,000 | 1.63 | 1.31 | -0.32 | buy |
| HighVista Strategies LLC | 59,643 | 182,929 | +123,286 | 0.30 | 0.92 | +0.62 | buy |
| Polar Capital Holdings Plc | 1,269,131 | 1,359,169 | +90,038 | 0.11 | 0.11 | -0.01 | buy |
| University of Wisconsin Foundation | 416,750 | 484,745 | +67,995 | 6.85 | 7.80 | +0.95 | buy |
| Rock Springs Capital Management LP | 912,955 | 972,198 | +59,243 | 0.92 | 1.04 | +0.12 | buy |
| Aegis Wealth Management LLC | 75,908 | 135,030 | +59,122 | 0.84 | 1.40 | +0.56 | buy |
| Darwin Wealth Management, LLC | 115,267 | 154,862 | +39,595 | 0.70 | 0.87 | +0.17 | buy |
| WASATCH ADVISORS LP | 406,960 | 443,668 | +36,708 | 0.05 | 0.05 | +0.01 | buy |
| E Fund Management Co., Ltd. | 12,274 | 23,001 | +10,727 | 0.01 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 247,997 | 258,132 | +10,135 | 1.02 | 0.92 | -0.10 | buy |
| MPM BioImpact LLC | 1,405,388 | 1,408,152 | +2,764 | 3.15 | 1.97 | -1.17 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 47,875 | 49,475 | +1,600 | 0.15 | 0.15 | +0.00 | buy |
| Chung Wu Investment Group, LLC | 2,800 | 2,000 | -800 | 0.04 | 0.03 | -0.01 | sell |
| Clearbridge Investments, LLC | 407,794 | 403,225 | -4,569 | 0.01 | 0.01 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 700,653 | 673,949 | -26,704 | 0.30 | 0.32 | +0.02 | sell |
| Artisan Partners Limited Partnership | 649,691 | 619,457 | -30,234 | 0.02 | 0.02 | -0.00 | sell |
| SummitTX Capital, L.P. | 243,276 | 196,188 | -47,088 | 0.14 | 0.11 | -0.03 | sell |
| Neo Ivy Capital Management | 237,467 | 168,753 | -68,714 | 0.73 | 0.81 | +0.07 | sell |
| ARMISTICE CAPITAL, LLC | 3,249,708 | 3,175,110 | -74,598 | 1.56 | 1.90 | +0.34 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 392,894 | 160,594 | -232,300 | 1.61 | 0.50 | -1.11 | sell |
| Sofinnova Investments, Inc. | 2,254,161 | 1,633,897 | -620,264 | 1.90 | 1.48 | -0.42 | sell |
| Deep Track Capital, LP | 2,650,000 | 2,000,000 | -650,000 | 1.18 | 0.75 | -0.43 | sell |
| Vivo Capital, LLC | 2,614,960 | 1,557,466 | -1,057,494 | 3.31 | 2.35 | -0.96 | sell |