| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 17,540,089 | 30,785,801 | +13,245,712 | 0.22 | 0.38 | +0.17 | buy |
| JANUS HENDERSON GROUP PLC | 13,887,722 | 13,647,376 | -240,346 | 0.12 | 0.12 | -0.00 | sell |
| BlackRock, Inc. | 11,190,838 | 11,699,870 | +509,032 | 0.00 | 0.00 | +0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 9,130,465 | 9,130,465 | 0 | 20.64 | 20.95 | +0.31 | hold |
| FMR LLC | 6,569,921 | 8,908,980 | +2,339,059 | 0.01 | 0.01 | +0.00 | buy |
| Orbis Allan Gray Ltd | 4,801,928 | 6,762,231 | +1,960,303 | 0.39 | 0.52 | +0.12 | buy |
| STATE STREET CORP | 6,692,745 | 6,653,746 | -38,999 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 3,478,944 | 4,668,839 | +1,189,895 | 1.25 | 1.67 | +0.43 | buy |
| FCPM III SERVICES B.V. | 5,462,846 | 4,644,386 | -818,460 | 14.01 | 11.66 | -2.35 | sell |
| TCG Crossover Management, LLC | 4,615,144 | 4,615,144 | 0 | 2.99 | 2.39 | -0.59 | hold |
| Vestal Point Capital, LP | 120,000 | 4,000,000 | +3,880,000 | 0.09 | 2.03 | +1.94 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,263,429 | 3,504,114 | +240,685 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,549,909 | 3,253,473 | -296,436 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 3,249,708 | 3,175,110 | -74,598 | 1.56 | 1.90 | +0.34 | sell |
| Frazier Life Sciences Management, L.P. | 3,153,082 | 3,153,082 | 0 | 1.66 | 1.47 | -0.19 | hold |
| ORBIMED ADVISORS LLC | 2,202,184 | 2,917,884 | +715,700 | 0.88 | 1.15 | +0.27 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,323,789 | 2,328,373 | +4,584 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 3,502,941 | 2,229,125 | -1,273,816 | 2.04 | 1.12 | -0.92 | sell |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 2.10 | 1.47 | -0.63 | hold |
| FRANKLIN RESOURCES INC | 2,006,638 | 2,009,082 | +2,444 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 2,650,000 | 2,000,000 | -650,000 | 1.18 | 0.75 | -0.43 | sell |
| SAMLYN CAPITAL, LLC | 1,493,075 | 1,922,543 | +429,468 | 0.47 | 0.60 | +0.13 | buy |
| GOLDMAN SACHS GROUP INC | 2,283,191 | 1,723,116 | -560,075 | 0.01 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 1,478,329 | 1,681,998 | +203,669 | 0.92 | 1.02 | +0.09 | buy |
| Palo Alto Investors LP | 1,472,197 | 1,652,972 | +180,775 | 4.01 | 4.58 | +0.57 | buy |
| Sofinnova Investments, Inc. | 2,254,161 | 1,633,897 | -620,264 | 1.90 | 1.48 | -0.42 | sell |
| Vivo Capital, LLC | 2,614,960 | 1,557,466 | -1,057,494 | 3.31 | 2.35 | -0.96 | sell |
| BANK OF AMERICA CORP /DE/ | 882,922 | 1,443,313 | +560,391 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,108,145 | 1,430,384 | +322,239 | 0.03 | 0.04 | +0.01 | buy |
| MPM BioImpact LLC | 1,405,388 | 1,408,152 | +2,764 | 3.15 | 1.97 | -1.17 | buy |
| Logos Global Management LP | 1,250,000 | 1,400,000 | +150,000 | 1.63 | 1.31 | -0.32 | buy |
| Fiera Capital Corp | 0 | 1,380,620 | +1,380,620 | 0.00 | 0.09 | +0.09 | buy |
| Polar Capital Holdings Plc | 1,269,131 | 1,359,169 | +90,038 | 0.11 | 0.11 | -0.01 | buy |
| NORTHERN TRUST CORP | 1,092,191 | 1,198,838 | +106,647 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,151,325 | 1,158,390 | +7,065 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,172,000 | 1,000,000 | -4,172,000 | 0.15 | 0.03 | -0.13 | sell |
| Rock Springs Capital Management LP | 912,955 | 972,198 | +59,243 | 0.92 | 1.04 | +0.12 | buy |
| Saturn V Capital Management LP | 1,788,616 | 966,609 | -822,007 | 6.42 | 3.17 | -3.25 | sell |
| DIMENSIONAL FUND ADVISORS LP | 98,074 | 951,589 | +853,515 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,213,559 | 929,003 | -284,556 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 255,160 | 834,176 | +579,016 | 0.01 | 0.03 | +0.02 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,138,868 | 821,849 | -317,019 | 0.24 | 0.15 | -0.08 | sell |
| BAKER BROS. ADVISORS LP | 813,449 | 813,449 | 0 | 0.09 | 0.08 | -0.01 | hold |
| Nuveen, LLC | 621,310 | 718,333 | +97,023 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 700,653 | 673,949 | -26,704 | 0.30 | 0.32 | +0.02 | sell |
| Artisan Partners Limited Partnership | 649,691 | 619,457 | -30,234 | 0.02 | 0.02 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 470,645 | 533,600 | +62,955 | 0.01 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 419,756 | 529,312 | +109,556 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 835,200 | 506,075 | -329,125 | 2.80 | 1.76 | -1.04 | sell |
| Ensign Peak Advisors, Inc | 496,590 | 496,590 | 0 | 0.02 | 0.02 | -0.00 | hold |
| University of Wisconsin Foundation | 416,750 | 484,745 | +67,995 | 6.85 | 7.80 | +0.95 | buy |
| ALGERT GLOBAL LLC | 271,303 | 454,463 | +183,160 | 0.08 | 0.12 | +0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 530,338 | 451,644 | -78,694 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 406,960 | 443,668 | +36,708 | 0.05 | 0.05 | +0.01 | buy |
| Clearbridge Investments, LLC | 407,794 | 403,225 | -4,569 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 353,497 | 401,616 | +48,119 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 380,978 | 380,561 | -417 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 79,262 | 333,497 | +254,235 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 250,065 | 323,051 | +72,986 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 519,715 | 282,954 | -236,761 | 1.80 | 1.07 | -0.73 | sell |
| TFG Asset Management GP Ltd | 247,997 | 258,132 | +10,135 | 1.02 | 0.92 | -0.10 | buy |
| Qube Research & Technologies Ltd | 412,440 | 253,153 | -159,287 | 0.01 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 137,684 | 248,941 | +111,257 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 214,491 | 239,285 | +24,794 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 222,500 | 228,100 | +5,600 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 196,080 | 221,123 | +25,043 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,171,624 | 201,144 | -970,480 | 0.02 | 0.00 | -0.01 | sell |
| SummitTX Capital, L.P. | 243,276 | 196,188 | -47,088 | 0.14 | 0.11 | -0.03 | sell |
| RHUMBLINE ADVISERS | 175,020 | 187,223 | +12,203 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 182,986 | 182,986 | 0 | 0.23 | 0.20 | -0.04 | hold |
| Rafferty Asset Management, LLC | 233,835 | 182,977 | -50,858 | 0.02 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 59,643 | 182,929 | +123,286 | 0.30 | 0.92 | +0.62 | buy |
| Neo Ivy Capital Management | 237,467 | 168,753 | -68,714 | 0.73 | 0.81 | +0.07 | sell |
| BNP Paribas Asset Management Holding S.A. | 165,692 | 164,887 | -805 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 197,691 | 162,972 | -34,719 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 392,894 | 160,594 | -232,300 | 1.61 | 0.50 | -1.11 | sell |
| MILLENNIUM MANAGEMENT LLC | 904,389 | 158,548 | -745,841 | 0.01 | 0.00 | -0.01 | sell |
| Burkehill Global Management, LP | 155,000 | 155,000 | 0 | 0.20 | 0.14 | -0.06 | hold |
| Darwin Wealth Management, LLC | 115,267 | 154,862 | +39,595 | 0.70 | 0.87 | +0.17 | buy |
| Woodline Partners LP | 120,788 | 149,388 | +28,600 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 147,831 | 145,509 | -2,322 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 120,800 | 139,663 | +18,863 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 134,260 | 135,940 | +1,680 | 0.00 | 0.00 | +0.00 | buy |
| Aegis Wealth Management LLC | 75,908 | 135,030 | +59,122 | 0.84 | 1.40 | +0.56 | buy |
| SG Americas Securities, LLC | 265,384 | 112,626 | -152,758 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,215 | 108,724 | +10,509 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 118,122 | 96,462 | -21,660 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 95,682 | +95,682 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 86,438 | 86,609 | +171 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 70,659 | 84,238 | +13,579 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 676,979 | 83,147 | -593,832 | 0.01 | 0.00 | -0.01 | sell |
| PROFUND ADVISORS LLC | 86,746 | 82,138 | -4,608 | 0.05 | 0.05 | +0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 78,765 | +78,765 | 0.00 | 0.05 | +0.05 | buy |
| TUDOR INVESTMENT CORP ET AL | 147,621 | 77,031 | -70,590 | 0.02 | 0.01 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,191 | 75,469 | +4,278 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 69,599 | 72,841 | +3,242 | 0.01 | 0.01 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 68,766 | 69,215 | +449 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 63,653 | 68,571 | +4,918 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 68,393 | +68,393 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 18,547 | 68,188 | +49,641 | 0.00 | 0.00 | +0.00 | buy |