| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,091,587 | 6,387,138 | +3,295,551 | 1.30 | 3.49 | +2.19 | buy |
| JANUS HENDERSON GROUP PLC | 2,675,240 | 4,623,824 | +1,948,584 | 0.04 | 0.09 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,132,092 | 2,366,069 | +1,233,977 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,325,000 | 3,328,000 | +1,003,000 | 0.12 | 0.22 | +0.09 | buy |
| ArrowMark Colorado Holdings LLC | 382,416 | 919,416 | +537,000 | 0.12 | 0.39 | +0.26 | buy |
| Woodline Partners LP | 697,927 | 1,233,908 | +535,981 | 0.18 | 0.42 | +0.23 | buy |
| BAKER BROS. ADVISORS LP | 285,000 | 672,096 | +387,096 | 0.10 | 0.30 | +0.20 | buy |
| First Light Asset Management, LLC | 105,948 | 382,433 | +276,485 | 0.23 | 1.18 | +0.95 | buy |
| Ratan Capital Management LP | 29,000 | 230,900 | +201,900 | 0.44 | 2.47 | +2.03 | buy |
| JENNISON ASSOCIATES LLC | 1,207,551 | 1,327,222 | +119,671 | 0.02 | 0.03 | +0.01 | buy |
| ALGERT GLOBAL LLC | 27,423 | 97,370 | +69,947 | 0.03 | 0.12 | 0.00 | buy |
| CITADEL ADVISORS LLC | 4,254,276 | 4,316,006 | +61,730 | 0.17 | 0.21 | +0.04 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 184,500 | 212,500 | +28,000 | 3.40 | 6.32 | +2.91 | buy |
| PROFUND ADVISORS LLC | 53,447 | 27,421 | +26,026 | 0.06 | 0.04 | 0.00 | sell |
| Lisanti Capital Growth, LLC | 86,610 | 106,140 | +19,530 | 0.60 | 0.90 | +0.30 | buy |
| Crestline Management, LP | 75,000 | 92,390 | +17,390 | 0.19 | 0.25 | +0.07 | buy |
| OPPENHEIMER & CO INC | 28,529 | 38,455 | +9,926 | 0.01 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 451,824 | 461,028 | +9,204 | 0.33 | 0.49 | +0.16 | buy |
| Atika Capital Management LLC | 175,000 | 181,500 | +6,500 | 0.49 | 0.63 | +0.14 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137,751 | 142,303 | +4,552 | 0.00 | 0.01 | +0.00 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 31,325 | 35,175 | +3,850 | 0.16 | 0.21 | +0.05 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 33,125 | 32,944 | +181 | 0.07 | 0.07 | 0.00 | sell |
| Artal Group S.A. | 1,517,960 | 1,516,960 | -1,000 | 1.10 | 1.36 | +0.27 | sell |
| China Universal Asset Management Co., Ltd. | 15,573 | 11,498 | -4,075 | 0.06 | 0.06 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 7,326 | 2,687 | -4,639 | 0.11 | 0.05 | -0.06 | sell |
| EntryPoint Capital, LLC | 7,552 | 2,479 | -5,073 | 0.19 | 0.13 | -0.06 | sell |
| E Fund Management Co., Ltd. | 16,275 | 8,829 | -7,446 | 0.03 | 0.02 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 1,000,000 | 970,891 | -29,109 | 0.38 | 0.43 | +0.05 | sell |
| Informed Momentum Co LLC | 147,968 | 107,250 | -40,718 | 0.65 | 0.62 | -0.04 | sell |
| Octagon Capital Advisors LP | 1,242,945 | 1,180,798 | -62,147 | 4.29 | 6.88 | +2.59 | sell |
| WASATCH ADVISORS LP | 417,794 | 335,615 | -82,179 | 0.06 | 0.06 | +0.00 | sell |
| Monashee Investment Management LLC | 170,000 | 85,000 | -85,000 | 0.57 | 0.39 | -0.18 | sell |
| Candriam S.C.A. | 675,624 | 533,273 | -142,351 | 0.12 | 0.11 | -0.01 | sell |
| Rafferty Asset Management, LLC | 344,391 | 145,378 | -199,013 | 0.04 | 0.02 | -0.02 | sell |
| Sofinnova Investments, Inc. | 1,936,650 | 1,625,703 | -310,947 | 3.06 | 2.98 | -0.08 | sell |
| Deep Track Capital, LP | 4,555,383 | 4,000,000 | -555,383 | 3.72 | 4.22 | +0.50 | sell |
| Logos Global Management LP | 1,730,000 | 265,000 | -1,465,000 | 5.17 | 1.08 | -4.09 | sell |
| MPM ASSET MANAGEMENT LLC | 3,451,303 | 1,561,496 | -1,889,807 | 39.97 | 30.26 | -9.70 | sell |