| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,091,587 | 6,387,138 | +3,295,551 | 1.30 | 3.49 | +2.19 | buy |
| FMR LLC | 3,218,393 | 5,318,963 | +2,100,570 | 0.01 | 0.01 | +0.01 | buy |
| Holocene Advisors, LP | 0 | 2,076,352 | +2,076,352 | 0.00 | 0.31 | +0.31 | buy |
| JANUS HENDERSON GROUP PLC | 2,675,240 | 4,623,824 | +1,948,584 | 0.04 | 0.09 | +0.05 | buy |
| VANGUARD GROUP INC | 3,440,270 | 4,718,054 | +1,277,784 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,132,092 | 2,366,069 | +1,233,977 | 0.00 | 0.01 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 4,954,779 | 6,049,204 | +1,094,425 | 1.79 | 2.82 | +1.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,325,000 | 3,328,000 | +1,003,000 | 0.12 | 0.22 | +0.09 | buy |
| ArrowMark Colorado Holdings LLC | 382,416 | 919,416 | +537,000 | 0.12 | 0.39 | +0.26 | buy |
| Woodline Partners LP | 697,927 | 1,233,908 | +535,981 | 0.18 | 0.42 | +0.23 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 485,000 | +485,000 | 0.00 | 0.29 | +0.29 | buy |
| LMR Partners LLP | 0 | 477,000 | +477,000 | 0.00 | 0.36 | +0.36 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,307,604 | 1,774,653 | +467,049 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 452,213 | +452,213 | 0.00 | 0.05 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 1,661,088 | 2,095,749 | +434,661 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 285,000 | 672,096 | +387,096 | 0.10 | 0.30 | +0.20 | buy |
| Pictet Asset Management Holding SA | 0 | 294,748 | +294,748 | 0.00 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 105,948 | 382,433 | +276,485 | 0.23 | 1.18 | +0.95 | buy |
| Vestal Point Capital, LP | 0 | 225,000 | +225,000 | 0.00 | 0.59 | +0.59 | buy |
| MARSHALL WACE, LLP | 53,705 | 273,567 | +219,862 | 0.00 | 0.01 | +0.01 | buy |
| Ratan Capital Management LP | 29,000 | 230,900 | +201,900 | 0.44 | 2.49 | +2.05 | buy |
| Soleus Capital Management, L.P. | 0 | 201,000 | +201,000 | 0.00 | 0.63 | +0.63 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 76,934 | 260,367 | +183,433 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 8,912 | 159,154 | +150,242 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461,522 | 601,062 | +139,540 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 87,523 | 215,471 | +127,948 | 0.00 | 0.01 | +0.01 | buy |
| Global IMC LLC | 0 | 127,247 | +127,247 | 0.00 | 1.01 | +1.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 126,000 | +126,000 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 1,207,551 | 1,327,222 | +119,671 | 0.02 | 0.03 | +0.01 | buy |
| Avoro Capital Advisors LLC | 0 | 115,751 | +115,751 | 0.00 | 0.05 | +0.05 | buy |
| FEDERATED HERMES, INC. | 1,100,224 | 1,215,112 | +114,888 | 0.07 | 0.10 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 13,600 | 124,000 | +110,400 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 145,160 | 253,045 | +107,885 | 0.01 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 204,271 | 311,504 | +107,233 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.56 | +0.56 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.35 | +0.35 | buy |
| Trek Financial, LLC | 0 | 99,959 | +99,959 | 0.00 | 0.28 | +0.28 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 31,281 | 127,550 | +96,269 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 88,420 | +88,420 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 168,351 | 255,365 | +87,014 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 85,652 | +85,652 | 0.00 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 74,800 | 152,210 | +77,410 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 547,035 | 619,639 | +72,604 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 27,423 | 97,370 | +69,947 | 0.03 | 0.11 | +0.08 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64,342 | 126,244 | +61,902 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 4,254,276 | 4,316,006 | +61,730 | 0.12 | 0.15 | +0.03 | buy |
| NORGES BANK | 47,258 | 107,089 | +59,831 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 48,845 | +48,845 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 54,370 | 97,514 | +43,144 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 38,979 | 81,962 | +42,983 | 0.02 | 0.04 | +0.02 | buy |
| Cinctive Capital Management LP | 0 | 34,529 | +34,529 | 0.00 | 0.07 | +0.07 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 184,500 | 212,500 | +28,000 | 3.40 | 6.32 | +2.92 | buy |
| FIRST TRUST ADVISORS LP | 0 | 27,821 | +27,821 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 26,028 | +26,028 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 152,632 | 176,774 | +24,142 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 23,600 | +23,600 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 98,329 | 121,595 | +23,266 | 0.00 | 0.00 | +0.00 | buy |
| Virtue Capital Management, LLC | 0 | 22,227 | +22,227 | 0.00 | 0.17 | +0.17 | buy |
| Swiss National Bank | 85,200 | 105,900 | +20,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 20,605 | +20,605 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 86,610 | 106,140 | +19,530 | 0.60 | 0.90 | +0.30 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 19,152 | +19,152 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 17,869 | +17,869 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 17,546 | +17,546 | 0.00 | 0.01 | +0.01 | buy |
| Crestline Management, LP | 75,000 | 92,390 | +17,390 | 0.20 | 0.26 | +0.05 | buy |
| Genesee Capital Advisors, LLC | 0 | 16,359 | +16,359 | 0.00 | 0.28 | +0.28 | buy |
| MetLife Investment Management, LLC | 30,482 | 46,719 | +16,237 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 44,101 | 60,334 | +16,233 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 15,900 | +15,900 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 0 | 14,016 | +14,016 | 0.00 | 0.12 | +0.12 | buy |
| Tower Research Capital LLC (TRC) | 577 | 14,054 | +13,477 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,943 | 33,273 | +13,330 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 12,460 | +12,460 | 0.00 | 0.08 | +0.08 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,316 | 51,550 | +11,234 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 233,327 | 243,929 | +10,602 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 10,053 | +10,053 | 0.00 | 0.02 | +0.02 | buy |
| OPPENHEIMER & CO INC | 28,529 | 38,455 | +9,926 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 250,040 | 259,854 | +9,814 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,784 | 54,528 | +9,744 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 451,824 | 461,028 | +9,204 | 0.33 | 0.49 | +0.16 | buy |
| FORA Capital, LLC | 0 | 8,222 | +8,222 | 0.00 | 0.04 | +0.04 | buy |
| Creative Planning | 0 | 7,494 | +7,494 | 0.00 | 0.00 | +0.00 | buy |
| Compagnie Lombard Odier SCmA | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 27,078 | 34,040 | +6,962 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 175,000 | 181,500 | +6,500 | 0.56 | 0.74 | +0.19 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 6,451 | +6,451 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 6,137 | +6,137 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,957 | 26,060 | +6,103 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 5,740 | +5,740 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 5,698 | +5,698 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137,751 | 142,303 | +4,552 | 0.00 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 11,800 | 15,800 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 31,325 | 35,175 | +3,850 | 0.16 | 0.21 | +0.05 | buy |
| Russell Investments Group, Ltd. | 101,943 | 105,677 | +3,734 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 11,871 | 15,070 | +3,199 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,019 | 8,088 | +3,069 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 9,613 | 11,822 | +2,209 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,896 | 7,906 | +2,010 | 0.01 | 0.01 | +0.00 | buy |