| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,714,392 | 9,714,392 | 0 | 1.70 | 1.56 | -0.14 | hold |
| JANUS HENDERSON GROUP PLC | 10,353,416 | 9,437,962 | -915,454 | 0.06 | 0.04 | -0.02 | sell |
| Atlas Venture Life Science Advisors, LLC | 9,130,465 | 9,130,465 | 0 | 18.30 | 13.12 | -5.18 | hold |
| BlackRock, Inc. | 8,046,938 | 8,078,428 | +31,490 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 7,406,344 | 7,651,157 | +244,813 | 0.00 | 0.00 | -0.00 | buy |
| FCPM III SERVICES B.V. | 5,462,846 | 5,462,846 | 0 | 13.81 | 14.09 | +0.28 | hold |
| FMR LLC | 5,195,294 | 5,293,369 | +98,075 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 2,717,987 | 4,836,437 | +2,118,450 | 1.60 | 2.38 | +0.78 | buy |
| TCG Crossover Management, LLC | 2,650,150 | 3,766,660 | +1,116,510 | 3.78 | 4.10 | +0.31 | buy |
| STATE STREET CORP | 3,609,651 | 3,355,678 | -253,973 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 3,621,344 | 3,273,349 | -347,995 | 1.33 | 1.07 | -0.27 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 3,191,000 | +3,191,000 | 0.00 | 0.05 | +0.05 | buy |
| JPMORGAN CHASE & CO | 2,531,313 | 3,086,779 | +555,466 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,768,000 | 2,560,000 | -208,000 | 0.77 | 0.92 | +0.15 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,820,415 | 2,383,953 | +563,538 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,955,505 | 2,253,670 | +298,165 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,313,403 | 2,247,390 | -66,013 | 0.86 | 0.80 | -0.06 | sell |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 1.93 | 1.55 | -0.38 | hold |
| Logos Global Management LP | 500,000 | 1,900,000 | +1,400,000 | 0.93 | 2.42 | +1.49 | buy |
| T. Rowe Price Investment Management, Inc. | 1,167,975 | 1,793,590 | +625,615 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,690,567 | 1,690,567 | 0 | 0.27 | 0.23 | -0.04 | hold |
| Frazier Life Sciences Management, L.P. | 1,443,341 | 1,505,984 | +62,643 | 0.69 | 0.57 | -0.12 | buy |
| Saturn V Capital Management LP | 0 | 1,455,429 | +1,455,429 | 0.00 | 5.62 | +5.62 | buy |
| MPM BioImpact LLC | 0 | 1,446,361 | +1,446,361 | 0.00 | 2.39 | +2.39 | buy |
| FRANKLIN RESOURCES INC | 1,414,835 | 1,390,140 | -24,695 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,391,587 | 1,362,176 | -29,411 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 994,886 | 1,340,443 | +345,557 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 1,114,960 | 1,114,960 | 0 | 1.54 | 1.09 | -0.46 | hold |
| ORBIMED ADVISORS LLC | 1,014,611 | 1,031,400 | +16,789 | 0.25 | 0.25 | -0.01 | buy |
| CITADEL ADVISORS LLC | 3,009,389 | 943,874 | -2,065,515 | 0.03 | 0.01 | -0.02 | sell |
| NORTHERN TRUST CORP | 722,462 | 841,037 | +118,575 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 680,836 | 791,987 | +111,151 | 0.01 | 0.01 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,388,425 | 791,120 | -597,305 | 0.05 | 0.03 | -0.03 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 289,603 | 789,425 | +499,822 | 0.03 | 0.07 | +0.04 | buy |
| ArrowMark Colorado Holdings LLC | 897,946 | 770,225 | -127,721 | 0.15 | 0.13 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 654,131 | 745,071 | +90,940 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 345,062 | 745,062 | +400,000 | 0.30 | 0.50 | +0.20 | buy |
| Vestal Point Capital, LP | 1,800,000 | 727,500 | -1,072,500 | 1.34 | 0.36 | -0.98 | sell |
| MPM ASSET MANAGEMENT LLC | 682,376 | 682,376 | 0 | 10.28 | 14.99 | +4.71 | hold |
| Sofinnova Investments, Inc. | 716,896 | 614,865 | -102,031 | 0.57 | 0.40 | -0.17 | sell |
| Jain Global LLC | 0 | 596,167 | +596,167 | 0.00 | 0.09 | +0.09 | buy |
| Rock Springs Capital Management LP | 524,499 | 580,998 | +56,499 | 0.31 | 0.34 | +0.03 | buy |
| Woodline Partners LP | 574,435 | 574,853 | +418 | 0.04 | 0.03 | -0.01 | buy |
| ALGERT GLOBAL LLC | 476,007 | 558,896 | +82,889 | 0.12 | 0.11 | -0.01 | buy |
| WASATCH ADVISORS LP | 511,048 | 557,937 | +46,889 | 0.03 | 0.03 | -0.00 | buy |
| Candriam S.C.A. | 463,368 | 524,161 | +60,793 | 0.03 | 0.03 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 269,976 | 513,801 | +243,825 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 287,653 | 508,940 | +221,287 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 488,498 | +488,498 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 314,586 | 483,963 | +169,377 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 447,807 | +447,807 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 224,176 | 385,248 | +161,072 | 0.17 | 0.21 | +0.04 | buy |
| ROYAL BANK OF CANADA | 0 | 374,969 | +374,969 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 358,837 | 363,837 | +5,000 | 1.22 | 1.15 | -0.08 | buy |
| Trexquant Investment LP | 334,443 | 362,310 | +27,867 | 0.04 | 0.04 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 146,294 | 333,453 | +187,159 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 231,224 | 320,490 | +89,266 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 317,664 | 318,653 | +989 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 157,791 | 293,644 | +135,853 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 206,965 | 285,004 | +78,039 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 115,534 | 278,362 | +162,828 | 0.02 | 0.03 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 147,365 | 277,259 | +129,894 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 232,626 | 269,664 | +37,038 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 20,150 | 266,073 | +245,923 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 333,391 | 264,976 | -68,415 | 0.66 | 0.54 | -0.13 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 329,262 | 221,416 | -107,846 | 0.85 | 0.55 | -0.30 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 242,825 | 205,626 | -37,199 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 0 | 200,266 | +200,266 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 223,215 | 199,831 | -23,384 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 58,525 | 197,148 | +138,623 | 0.01 | 0.04 | +0.03 | buy |
| Exome Asset Management LLC | 258,391 | 195,933 | -62,458 | 2.42 | 1.54 | -0.88 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 154,354 | 186,015 | +31,661 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 41,844 | 181,740 | +139,896 | 0.00 | 0.00 | +0.00 | buy |
| Darwin Wealth Management, LLC | 52,090 | 172,656 | +120,566 | 0.41 | 0.57 | +0.16 | buy |
| Engineers Gate Manager LP | 84,918 | 172,469 | +87,551 | 0.01 | 0.02 | +0.01 | buy |
| AXA S.A. | 251,817 | 162,745 | -89,072 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 133,627 | 154,541 | +20,914 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 78,179 | 142,719 | +64,540 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 118,300 | 140,400 | +22,100 | 0.00 | 0.00 | -0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 138,375 | +138,375 | 0.00 | 0.24 | +0.24 | buy |
| JANE STREET GROUP, LLC | 117,006 | 128,962 | +11,956 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 80,665 | 124,628 | +43,963 | 0.06 | 0.03 | -0.03 | buy |
| Point72 Asset Management, L.P. | 1,528,534 | 123,284 | -1,405,250 | 0.04 | 0.00 | -0.04 | sell |
| UBS Group AG | 357,754 | 121,792 | -235,962 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 115,078 | 120,084 | +5,006 | 0.04 | 0.03 | -0.01 | buy |
| SummitTX Capital, L.P. | 129,858 | 118,961 | -10,897 | 0.06 | 0.05 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 92,652 | 115,765 | +23,113 | 0.10 | 0.11 | +0.01 | buy |
| Rafferty Asset Management, LLC | 147,353 | 110,248 | -37,105 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,635 | 101,612 | +47,977 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 167,625 | 98,240 | -69,385 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 66,293 | 82,142 | +15,849 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,630 | 79,354 | +10,724 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 68,473 | 78,533 | +10,060 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 41,176 | 75,338 | +34,162 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 59,411 | 66,413 | +7,002 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 77,351 | 66,026 | -11,325 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 194,955 | 61,527 | -133,428 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 48,796 | 56,844 | +8,048 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 56,466 | 56,810 | +344 | 0.00 | 0.00 | -0.00 | buy |