| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Siren, L.L.C. | 2,717,987 | 4,836,437 | +2,118,450 | 1.60 | 2.38 | +0.78 | buy |
| Logos Global Management LP | 500,000 | 1,900,000 | +1,400,000 | 0.93 | 2.42 | +1.49 | buy |
| TCG Crossover Management, LLC | 2,650,150 | 3,766,660 | +1,116,510 | 3.78 | 4.10 | +0.31 | buy |
| JANUS HENDERSON GROUP PLC | 10,353,416 | 9,437,962 | +915,454 | 0.07 | 0.04 | 0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 1,167,975 | 1,793,590 | +625,615 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,820,415 | 2,383,953 | +563,538 | 0.00 | 0.00 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 289,603 | 789,425 | +499,822 | 0.03 | 0.07 | +0.04 | buy |
| Nantahala Capital Management, LLC | 345,062 | 745,062 | +400,000 | 0.14 | 0.28 | +0.13 | buy |
| Aberdeen Group plc | 314,586 | 483,963 | +169,377 | 0.01 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 224,176 | 385,248 | +161,072 | 0.17 | 0.21 | +0.04 | buy |
| TWINBEECH CAPITAL LP | 58,525 | 197,148 | +138,623 | 0.01 | 0.04 | +0.03 | buy |
| Darwin Wealth Management, LLC | 52,090 | 172,656 | +120,566 | 0.44 | 0.57 | +0.13 | buy |
| ALGERT GLOBAL LLC | 476,007 | 558,896 | +82,889 | 0.12 | 0.11 | 0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,443,341 | 1,505,984 | +62,643 | 0.69 | 0.57 | -0.12 | buy |
| Candriam S.C.A. | 463,368 | 524,161 | +60,793 | 0.03 | 0.03 | -0.00 | buy |
| Rock Springs Capital Management LP | 524,499 | 580,998 | +56,499 | 0.31 | 0.34 | +0.03 | buy |
| WASATCH ADVISORS LP | 511,048 | 557,937 | +46,889 | 0.03 | 0.03 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 80,665 | 124,628 | +43,963 | 0.06 | 0.03 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 242,825 | 205,626 | +37,199 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 92,652 | 115,765 | +23,113 | 0.07 | 0.11 | +0.03 | buy |
| ORBIMED ADVISORS LLC | 1,014,611 | 1,031,400 | +16,789 | 0.25 | 0.25 | -0.01 | buy |
| Compagnie Lombard Odier SCmA | 7,000 | 18,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 44,865 | 55,215 | +10,350 | 0.08 | 0.08 | -0.00 | buy |
| Ikarian Capital, LLC | 358,837 | 363,837 | +5,000 | 0.46 | 0.67 | +0.20 | buy |
| Quarry LP | 4,500 | 7,000 | +2,500 | 0.01 | 0.02 | 0.00 | buy |
| CAXTON ASSOCIATES LLP | 14,972 | 16,599 | +1,627 | 0.01 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 574,435 | 574,853 | +418 | 0.04 | 0.03 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 22,690 | 22,829 | +139 | 0.02 | 0.02 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 6,413 | 6,503 | +90 | 0.02 | 0.02 | +0.00 | buy |
| Optimize Financial Inc | 14,761 | 14,657 | -104 | 0.11 | 0.09 | -0.03 | sell |
| E Fund Management Co., Ltd. | 13,771 | 12,274 | -1,497 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 30,099 | 23,063 | -7,036 | 0.06 | 0.04 | -0.02 | sell |
| PROFUND ADVISORS LLC | 30,719 | 23,642 | -7,077 | 0.01 | 0.01 | -0.01 | sell |
| SummitTX Capital, L.P. | 129,858 | 118,961 | -10,897 | 0.06 | 0.05 | -0.01 | sell |
| Voleon Capital Management LP | 59,673 | 44,723 | -14,950 | 0.05 | 0.02 | -0.03 | sell |
| Rafferty Asset Management, LLC | 147,353 | 110,248 | -37,105 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 78,420 | 26,324 | -52,096 | 0.32 | 0.09 | -0.22 | sell |
| Exome Asset Management LLC | 258,391 | 195,933 | -62,458 | 2.42 | 1.54 | -0.88 | sell |
| PERCEPTIVE ADVISORS LLC | 2,313,403 | 2,247,390 | -66,013 | 0.85 | 0.79 | -0.06 | sell |
| Palo Alto Investors LP | 333,391 | 264,976 | -68,415 | 0.66 | 0.54 | -0.13 | sell |
| Sofinnova Investments, Inc. | 716,896 | 614,865 | -102,031 | 0.49 | 0.36 | -0.13 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 329,262 | 221,416 | -107,846 | 0.79 | 0.49 | -0.30 | sell |
| ArrowMark Colorado Holdings LLC | 897,946 | 770,225 | -127,721 | 0.15 | 0.13 | -0.02 | sell |
| ARMISTICE CAPITAL, LLC | 2,768,000 | 2,560,000 | -208,000 | 0.43 | 0.42 | -0.01 | sell |
| BRAIDWELL LP | 3,621,344 | 3,273,349 | -347,995 | 1.33 | 1.07 | -0.27 | sell |
| Vestal Point Capital, LP | 1,800,000 | 727,500 | -1,072,500 | 1.34 | 0.36 | -0.98 | sell |