| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 30,785,801 | 30,912,287 | +126,486 | 0.38 | 0.45 | +0.07 | buy |
| BlackRock, Inc. | 11,699,870 | 12,404,330 | +704,460 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,908,980 | 11,207,000 | +2,298,020 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 6,653,746 | 7,458,263 | +804,517 | 0.00 | 0.00 | +0.00 | buy |
| Orbis Allan Gray Ltd | 6,762,231 | 7,006,542 | +244,311 | 0.52 | 0.53 | +0.02 | buy |
| Atlas Venture Life Science Advisors, LLC | 9,130,465 | 6,800,099 | -2,330,366 | 20.95 | 17.14 | -3.82 | sell |
| TCG Crossover Management, LLC | 4,615,144 | 4,615,144 | 0 | 2.39 | 2.46 | +0.07 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,328,373 | 3,936,806 | +1,608,433 | 0.00 | 0.01 | +0.00 | buy |
| FCPM III SERVICES B.V. | 4,644,386 | 3,848,256 | -796,130 | 11.66 | 11.39 | -0.27 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,504,114 | 3,743,427 | +239,313 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 4,000,000 | 3,375,000 | -625,000 | 2.03 | 1.75 | -0.28 | sell |
| ORBIMED ADVISORS LLC | 2,917,884 | 3,235,684 | +317,800 | 1.15 | 1.36 | +0.21 | buy |
| Frazier Life Sciences Management, L.P. | 3,153,082 | 3,153,082 | 0 | 1.47 | 1.53 | +0.05 | hold |
| JPMORGAN CHASE & CO | 3,253,473 | 3,151,656 | -101,817 | 0.00 | 0.00 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 3,175,110 | 3,087,226 | -87,884 | 1.90 | 1.90 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 4,668,839 | 2,689,235 | -1,979,604 | 1.67 | 0.93 | -0.74 | sell |
| Logos Global Management LP | 1,400,000 | 2,550,000 | +1,150,000 | 1.31 | 2.44 | +1.13 | buy |
| BANK OF AMERICA CORP /DE/ | 1,443,313 | 2,233,398 | +790,085 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 1.47 | 1.46 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 1,723,116 | 2,157,195 | +434,079 | 0.00 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 2,229,125 | 2,129,125 | -100,000 | 1.12 | 0.96 | -0.16 | sell |
| FRANKLIN RESOURCES INC | 2,009,082 | 2,030,819 | +21,737 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 951,589 | 1,946,479 | +994,890 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 1,408,152 | 1,922,093 | +513,941 | 1.97 | 2.60 | +0.63 | buy |
| SAMLYN CAPITAL, LLC | 1,922,543 | 1,754,708 | -167,835 | 0.60 | 0.65 | +0.05 | sell |
| Sofinnova Investments, Inc. | 1,633,897 | 1,658,384 | +24,487 | 1.48 | 1.97 | +0.48 | buy |
| Palo Alto Investors LP | 1,652,972 | 1,647,521 | -5,451 | 4.58 | 5.06 | +0.47 | sell |
| Vivo Capital, LLC | 1,557,466 | 1,557,466 | 0 | 2.35 | 3.16 | +0.81 | hold |
| Aberdeen Group plc | 1,430,384 | 1,539,434 | +109,050 | 0.04 | 0.05 | +0.01 | buy |
| Deep Track Capital, LP | 2,000,000 | 1,500,000 | -500,000 | 0.75 | 0.49 | -0.26 | sell |
| MARSHALL WACE, LLP | 83,147 | 1,488,917 | +1,405,770 | 0.00 | 0.03 | +0.03 | buy |
| Polar Capital Holdings Plc | 1,359,169 | 1,286,811 | -72,358 | 0.11 | 0.08 | -0.03 | sell |
| NORTHERN TRUST CORP | 1,198,838 | 1,278,081 | +79,243 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,202,203 | +1,202,203 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,158,390 | 1,202,203 | +43,813 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 201,144 | 1,143,958 | +942,814 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 966,609 | 1,057,493 | +90,884 | 3.17 | 3.37 | +0.19 | buy |
| Novo Holdings A/S | 0 | 960,394 | +960,394 | 0.00 | 1.24 | +1.24 | buy |
| Rock Springs Capital Management LP | 972,198 | 942,154 | -30,044 | 1.04 | 1.02 | -0.02 | sell |
| BRAIDWELL LP | 1,681,998 | 921,598 | -760,400 | 1.02 | 0.76 | -0.26 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 821,849 | 874,138 | +52,289 | 0.15 | 0.18 | +0.03 | buy |
| BAKER BROS. ADVISORS LP | 813,449 | 813,449 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Fiera Capital Corp | 1,380,620 | 789,989 | -590,631 | 0.09 | 0.06 | -0.02 | sell |
| MORGAN STANLEY | 929,003 | 746,200 | -182,803 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 619,457 | 659,786 | +40,329 | 0.02 | 0.02 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 451,644 | 576,350 | +124,706 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 529,312 | 548,112 | +18,800 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 454,463 | 506,273 | +51,810 | 0.12 | 0.13 | +0.01 | buy |
| WASATCH ADVISORS LP | 443,668 | 443,668 | 0 | 0.05 | 0.06 | +0.01 | hold |
| UBS Group AG | 380,561 | 443,284 | +62,723 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 158,548 | 431,850 | +273,302 | 0.00 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 403,225 | 415,131 | +11,906 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 401,616 | 409,801 | +8,185 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 673,949 | 397,221 | -276,728 | 0.32 | 0.37 | +0.04 | sell |
| Nuveen, LLC | 718,333 | 386,787 | -331,546 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 533,600 | 360,572 | -173,028 | 0.02 | 0.01 | -0.00 | sell |
| TFG Asset Management GP Ltd | 258,132 | 356,657 | +98,525 | 0.92 | 1.29 | +0.37 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 333,497 | 355,953 | +22,456 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 338,565 | +338,565 | 0.00 | 0.27 | +0.27 | buy |
| University of Wisconsin Foundation | 484,745 | 313,559 | -171,186 | 7.80 | 5.51 | -2.29 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 78,765 | 305,794 | +227,029 | 0.05 | 0.15 | +0.10 | buy |
| Squarepoint Ops LLC | 834,176 | 300,074 | -534,102 | 0.03 | 0.01 | -0.02 | sell |
| Fisher Asset Management, LLC | 323,051 | 298,505 | -24,546 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 162,972 | 298,317 | +135,345 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 496,590 | 289,730 | -206,860 | 0.02 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 239,285 | 269,985 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 245,278 | +245,278 | 0.00 | 0.01 | +0.01 | buy |
| Catalio Capital Management, LP | 282,954 | 244,929 | -38,025 | 1.07 | 1.02 | -0.05 | sell |
| DEUTSCHE BANK AG\ | 221,123 | 242,392 | +21,269 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 228,100 | 232,000 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 145,509 | 220,664 | +75,155 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 160,594 | 199,594 | +39,000 | 0.50 | 0.63 | +0.13 | buy |
| SummitTX Capital, L.P. | 196,188 | 194,643 | -1,545 | 0.11 | 0.11 | +0.00 | sell |
| CITIGROUP INC | 37,797 | 187,915 | +150,118 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 187,223 | 183,799 | -3,424 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 86,609 | 174,457 | +87,848 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 135,940 | 172,080 | +36,140 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 182,929 | 171,961 | -10,968 | 0.92 | 0.87 | -0.04 | sell |
| ALPS ADVISORS INC | 0 | 167,082 | +167,082 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 248,941 | 164,598 | -84,343 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 164,887 | 157,916 | -6,971 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 65,158 | 156,203 | +91,045 | 0.02 | 0.07 | +0.05 | buy |
| Darwin Wealth Management, LLC | 154,862 | 155,270 | +408 | 0.87 | 0.94 | +0.07 | buy |
| AXXCESS WEALTH MANAGEMENT, LLC | 0 | 155,270 | +155,270 | 0.00 | 0.05 | +0.05 | buy |
| Aegis Wealth Management LLC | 135,030 | 150,030 | +15,000 | 1.40 | 1.57 | +0.17 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 150,000 | -850,000 | 0.03 | 0.00 | -0.02 | sell |
| Woodline Partners LP | 149,388 | 149,388 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 139,663 | 135,147 | -4,516 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 134,752 | +134,752 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 42,710 | 125,786 | +83,076 | 0.01 | 0.04 | +0.02 | buy |
| Jain Global LLC | 0 | 116,341 | +116,341 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 182,977 | 115,102 | -67,875 | 0.01 | 0.01 | -0.01 | sell |
| Russell Investments Group, Ltd. | 40,036 | 105,417 | +65,381 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 96,462 | 97,940 | +1,478 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 112,626 | 97,648 | -14,978 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 84,238 | 84,054 | -184 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 72,841 | 79,775 | +6,934 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,850 | 78,622 | +14,772 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 75,469 | 76,195 | +726 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 54,229 | 75,859 | +21,630 | 0.00 | 0.00 | +0.00 | buy |