| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 577,642 | 1,035,136 | +457,494 | 0.45 | 1.02 | +0.57 | buy |
| BRAIDWELL LP | 1,377,872 | 1,821,972 | +444,100 | 0.51 | 0.52 | +0.01 | buy |
| Logos Global Management LP | 1,780,000 | 2,180,000 | +400,000 | 2.77 | 2.79 | +0.02 | buy |
| ARMISTICE CAPITAL, LLC | 912,000 | 1,200,000 | +288,000 | 0.26 | 0.32 | +0.06 | buy |
| Sofinnova Investments, Inc. | 441,048 | 685,133 | +244,085 | 0.33 | 0.43 | +0.10 | buy |
| Altium Capital Management LLC | 155,000 | 315,000 | +160,000 | 1.36 | 1.63 | +0.27 | buy |
| Nantahala Capital Management, LLC | 593,164 | 683,164 | +90,000 | 0.81 | 0.78 | -0.03 | buy |
| ALGERT GLOBAL LLC | 239,072 | 158,713 | +80,359 | 0.12 | 0.07 | 0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 73,000 | 146,500 | +73,500 | 0.56 | 0.95 | +0.40 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 175,752 | 110,752 | +65,000 | 0.07 | 0.03 | 0.00 | sell |
| Rafferty Asset Management, LLC | 117,264 | 139,409 | +22,145 | 0.01 | 0.01 | -0.00 | buy |
| Corton Capital Inc. | 13,133 | 19,926 | +6,793 | 0.07 | 0.09 | +0.02 | buy |
| PROFUND ADVISORS LLC | 21,662 | 23,793 | +2,131 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 764 | 1,558 | +794 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 21,235 | 20,938 | -297 | 0.04 | 0.03 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 8,769 | 7,972 | -797 | 0.06 | 0.04 | -0.02 | sell |
| B. Metzler seel. Sohn & Co. AG | 37,946 | 18,973 | -18,973 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 382,576 | 335,884 | -46,692 | 0.05 | 0.04 | -0.02 | sell |
| Deep Track Capital, LP | 2,499,912 | 2,403,672 | -96,240 | 1.31 | 0.84 | -0.48 | sell |
| WASATCH ADVISORS LP | 2,259,535 | 1,687,802 | -571,733 | 0.15 | 0.10 | -0.06 | sell |