| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,318,963 | 9,026,697 | +3,707,734 | 0.01 | 0.02 | +0.01 | buy |
| Atlas Venture Life Science Advisors, LLC | 8,020,136 | 8,020,136 | 0 | 29.80 | 26.71 | -3.10 | hold |
| VANGUARD GROUP INC | 4,718,054 | 6,864,137 | +2,146,083 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 6,387,138 | 6,818,641 | +431,503 | 3.49 | 3.54 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 4,623,824 | 6,813,163 | +2,189,339 | 0.09 | 0.13 | +0.04 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,049,204 | 6,381,144 | +331,940 | 2.82 | 2.64 | -0.18 | buy |
| FCPM III SERVICES B.V. | 7,845,364 | 5,954,069 | -1,891,295 | 40.83 | 36.73 | -4.10 | sell |
| STATE STREET CORP | 3,200,969 | 3,641,859 | +440,890 | 0.00 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 4,000,000 | 3,282,000 | -718,000 | 4.22 | 3.76 | -0.45 | sell |
| CITADEL ADVISORS LLC | 4,316,006 | 2,939,340 | -1,376,666 | 0.15 | 0.11 | -0.04 | sell |
| TCG Crossover Management, LLC | 2,650,150 | 2,650,150 | 0 | 9.75 | 8.07 | -1.68 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,366,069 | 2,636,293 | +270,224 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,328,000 | 2,402,972 | -925,028 | 0.22 | 0.15 | -0.07 | sell |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 4.89 | 4.09 | -0.80 | hold |
| Holocene Advisors, LP | 2,076,352 | 1,982,640 | -93,712 | 0.31 | 0.29 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,774,653 | 1,859,413 | +84,760 | 0.01 | 0.01 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,327,222 | 1,346,952 | +19,730 | 0.03 | 0.03 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,714,496 | 1,342,500 | -371,996 | 0.02 | 0.01 | -0.01 | sell |
| First Light Asset Management, LLC | 382,433 | 1,257,285 | +874,852 | 1.18 | 3.76 | +2.57 | buy |
| FEDERATED HERMES, INC. | 1,215,112 | 1,217,170 | +2,058 | 0.10 | 0.10 | -0.01 | buy |
| ARMISTICE CAPITAL, LLC | 970,891 | 1,155,204 | +184,313 | 0.90 | 1.09 | +0.19 | buy |
| Vivo Capital, LLC | 1,635,136 | 1,114,960 | -520,176 | 5.33 | 3.31 | -2.02 | sell |
| MORGAN STANLEY | 559,052 | 1,053,262 | +494,210 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,233,908 | 977,440 | -256,468 | 0.42 | 0.30 | -0.12 | sell |
| ArrowMark Colorado Holdings LLC | 919,416 | 900,190 | -19,226 | 0.39 | 0.41 | +0.03 | sell |
| Sofinnova Investments, Inc. | 1,625,703 | 772,070 | -853,633 | 3.62 | 2.30 | -1.32 | sell |
| NORTHERN TRUST CORP | 619,639 | 721,502 | +101,863 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 718,650 | +718,650 | 0.00 | 0.07 | +0.07 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 718,144 | +718,144 | 0.00 | 0.55 | +0.55 | buy |
| ORBIMED ADVISORS LLC | 708,400 | 708,400 | 0 | 0.50 | 0.47 | -0.03 | hold |
| MPM ASSET MANAGEMENT LLC | 1,561,496 | 682,376 | -879,120 | 30.26 | 16.87 | -13.39 | sell |
| BAKER BROS. ADVISORS LP | 672,096 | 672,096 | 0 | 0.30 | 0.25 | -0.05 | hold |
| GOLDMAN SACHS GROUP INC | 2,095,749 | 670,484 | -1,425,265 | 0.01 | 0.00 | -0.01 | sell |
| Avoro Capital Advisors LLC | 115,751 | 650,000 | +534,249 | 0.05 | 0.34 | +0.29 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 601,062 | 648,652 | +47,590 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 243,929 | 625,719 | +381,790 | 0.00 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 427,039 | 555,644 | +128,605 | 0.46 | 0.68 | +0.22 | buy |
| Rock Springs Capital Management LP | 461,028 | 461,028 | 0 | 0.49 | 0.54 | +0.05 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 435,653 | +435,653 | 0.00 | 0.23 | +0.23 | buy |
| NORGES BANK | 107,089 | 432,327 | +325,238 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 6,000 | 428,000 | +422,000 | 0.00 | 0.08 | +0.08 | buy |
| Vida Ventures Advisors, LLC | 407,499 | 407,499 | 0 | 15.73 | 10.56 | -5.17 | hold |
| Candriam S.C.A. | 533,273 | 390,956 | -142,317 | 0.11 | 0.08 | -0.03 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 485,000 | 332,277 | -152,723 | 0.29 | 0.21 | -0.09 | sell |
| WASATCH ADVISORS LP | 335,615 | 324,099 | -11,516 | 0.06 | 0.06 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 312,752 | 312,752 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Pictet Asset Management Holding SA | 294,748 | 304,705 | +9,957 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 176,774 | 291,712 | +114,938 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,180,798 | 262,726 | -918,072 | 6.88 | 1.51 | -5.36 | sell |
| PRUDENTIAL FINANCIAL INC | 253,045 | 255,910 | +2,865 | 0.01 | 0.01 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 260,367 | 255,385 | -4,982 | 0.01 | 0.01 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 245,110 | +245,110 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 311,504 | 234,100 | -77,404 | 0.00 | 0.00 | -0.00 | sell |
| Ratan Capital Management LP | 230,900 | 230,900 | 0 | 2.49 | 2.24 | -0.26 | hold |
| AMERIPRISE FINANCIAL INC | 26,028 | 212,900 | +186,872 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 79,063 | 207,309 | +128,246 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 210,149 | 188,951 | -21,198 | 0.02 | 0.02 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 255,365 | 184,211 | -71,154 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 171,185 | 166,147 | -5,038 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 0 | 165,000 | +165,000 | 0.00 | 0.30 | +0.30 | buy |
| Rafferty Asset Management, LLC | 145,378 | 164,962 | +19,584 | 0.02 | 0.02 | +0.00 | buy |
| Logos Global Management LP | 265,000 | 160,000 | -105,000 | 1.08 | 0.64 | -0.43 | sell |
| Neuberger Berman Group LLC | 0 | 137,066 | +137,066 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 127,550 | 134,334 | +6,784 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 121,595 | 124,510 | +2,915 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 105,677 | 123,464 | +17,787 | 0.01 | 0.01 | +0.00 | buy |
| Artia Global Partners LP | 119,488 | 119,488 | 0 | 1.08 | 1.21 | +0.13 | hold |
| Crestline Management, LP | 92,390 | 117,681 | +25,291 | 0.26 | 0.24 | -0.02 | buy |
| Soleus Capital Management, L.P. | 201,000 | 117,500 | -83,500 | 0.63 | 0.35 | -0.27 | sell |
| TD ASSET MANAGEMENT INC | 152,210 | 108,830 | -43,380 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 60,334 | 106,447 | +46,113 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 126,244 | 106,215 | -20,029 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 105,900 | 105,100 | -800 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 215,471 | 104,517 | -110,954 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 357,518 | 102,480 | -255,038 | 0.04 | 0.01 | -0.03 | sell |
| JPMORGAN CHASE & CO | 97,514 | 101,750 | +4,236 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 97,370 | 94,960 | -2,410 | 0.11 | 0.09 | -0.02 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 142,303 | 90,041 | -52,262 | 0.01 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 8,495 | 89,198 | +80,703 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 45,196 | 83,229 | +38,033 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 88,420 | 73,040 | -15,380 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 65,482 | +65,482 | 0.00 | 0.81 | +0.81 | buy |
| CITIGROUP INC | 36,713 | 64,438 | +27,725 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 81,962 | 64,090 | -17,872 | 0.04 | 0.03 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 124,000 | 60,700 | -63,300 | 0.01 | 0.01 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 56,504 | +56,504 | 0.00 | 0.33 | +0.33 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,550 | 55,103 | +3,553 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,528 | 52,882 | -1,646 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,640 | 50,677 | +11,037 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 47,069 | 50,483 | +3,414 | 0.02 | 0.02 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 48,845 | 48,391 | -454 | 0.02 | 0.02 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 34,040 | 46,857 | +12,817 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 46,719 | 46,719 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 212,500 | 46,200 | -166,300 | 6.32 | 1.34 | -4.98 | sell |
| State of New Jersey Common Pension Fund D | 0 | 44,197 | +44,197 | 0.00 | 0.01 | +0.01 | buy |
| Corebridge Financial, Inc. | 43,414 | 43,147 | -267 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 259,854 | 42,422 | -217,432 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 226,422 | 41,661 | -184,761 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 41,157 | +41,157 | 0.00 | 0.01 | +0.01 | buy |