| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,623,824 | 6,813,163 | +2,189,339 | 0.09 | 0.13 | 0.00 | buy |
| First Light Asset Management, LLC | 382,433 | 1,257,285 | +874,852 | 1.18 | 3.76 | +2.57 | buy |
| Avoro Capital Advisors LLC | 115,751 | 650,000 | +534,249 | 0.05 | 0.34 | +0.29 | buy |
| RTW INVESTMENTS, LP | 6,387,138 | 6,818,641 | +431,503 | 3.49 | 3.54 | +0.05 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,049,204 | 6,381,144 | +331,940 | 2.82 | 2.64 | -0.18 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,366,069 | 2,636,293 | +270,224 | 0.01 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 970,891 | 1,155,204 | +184,313 | 0.43 | 0.66 | +0.23 | buy |
| EcoR1 Capital, LLC | 427,039 | 555,644 | +128,605 | 0.46 | 0.68 | +0.22 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 142,303 | 90,041 | +52,262 | 0.01 | 0.00 | -0.00 | sell |
| Crestline Management, LP | 92,390 | 117,681 | +25,291 | 0.25 | 0.22 | -0.03 | buy |
| JENNISON ASSOCIATES LLC | 1,327,222 | 1,346,952 | +19,730 | 0.03 | 0.03 | +0.00 | buy |
| Rafferty Asset Management, LLC | 145,378 | 164,962 | +19,584 | 0.02 | 0.02 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 32,944 | 19,318 | +13,626 | 0.07 | 0.05 | 0.00 | sell |
| FORA Capital, LLC | 8,222 | 18,180 | +9,958 | 0.04 | 0.08 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 11,498 | 19,310 | +7,812 | 0.06 | 0.08 | +0.02 | buy |
| ProShare Advisors LLC | 15,170 | 21,182 | +6,012 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 27,421 | 32,892 | +5,471 | 0.04 | 0.05 | 0.00 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 35,175 | 38,614 | +3,439 | 0.21 | 0.23 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 253,045 | 255,910 | +2,865 | 0.01 | 0.01 | 0.00 | buy |
| ALGERT GLOBAL LLC | 97,370 | 94,960 | +2,410 | 0.12 | 0.09 | 0.00 | sell |
| E Fund Management Co., Ltd. | 8,829 | 10,599 | +1,770 | 0.02 | 0.02 | +0.00 | buy |
| OPPENHEIMER & CO INC | 38,455 | 40,091 | +1,636 | 0.02 | 0.02 | +0.00 | buy |
| Privium Fund Management B.V. | 14,016 | 15,016 | +1,000 | 0.12 | 0.13 | +0.01 | buy |
| Virtue Capital Management, LLC | 22,227 | 23,208 | +981 | 0.17 | 0.17 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,687 | 2,736 | +49 | 0.05 | 0.05 | -0.00 | buy |
| Genesee Capital Advisors, LLC | 16,359 | 15,400 | -959 | 0.28 | 0.27 | -0.02 | sell |
| WASATCH ADVISORS LP | 335,615 | 324,099 | -11,516 | 0.06 | 0.06 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 919,416 | 900,190 | -19,226 | 0.39 | 0.41 | +0.03 | sell |
| TD ASSET MANAGEMENT INC | 152,210 | 108,830 | -43,380 | 0.01 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 201,000 | 117,500 | -83,500 | 0.63 | 0.35 | -0.27 | sell |
| Lisanti Capital Growth, LLC | 106,140 | 17,310 | -88,830 | 0.90 | 0.16 | -0.74 | sell |
| Holocene Advisors, LP | 2,076,352 | 1,982,640 | -93,712 | 0.31 | 0.29 | -0.02 | sell |
| Logos Global Management LP | 265,000 | 160,000 | -105,000 | 0.75 | 0.62 | -0.13 | sell |
| Candriam S.C.A. | 533,273 | 390,956 | -142,317 | 0.11 | 0.08 | -0.03 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 485,000 | 332,277 | -152,723 | 0.29 | 0.21 | -0.09 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 212,500 | 46,200 | -166,300 | 6.32 | 1.34 | -4.97 | sell |
| Woodline Partners LP | 1,233,908 | 977,440 | -256,468 | 0.42 | 0.30 | -0.12 | sell |
| Vivo Capital, LLC | 1,635,136 | 1,114,960 | -520,176 | 5.33 | 3.31 | -2.02 | sell |
| Deep Track Capital, LP | 4,000,000 | 3,282,000 | -718,000 | 4.22 | 3.76 | -0.45 | sell |
| Sofinnova Investments, Inc. | 1,625,703 | 772,070 | -853,633 | 2.98 | 2.20 | -0.78 | sell |
| MPM ASSET MANAGEMENT LLC | 1,561,496 | 682,376 | -879,120 | 30.26 | 16.87 | -13.39 | sell |
| Octagon Capital Advisors LP | 1,180,798 | 262,726 | -918,072 | 6.88 | 1.51 | -5.36 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,328,000 | 2,402,972 | -925,028 | 0.22 | 0.15 | -0.07 | sell |
| CITADEL ADVISORS LLC | 4,316,006 | 2,939,340 | -1,376,666 | 0.21 | 0.16 | -0.05 | sell |
| FCPM III SERVICES B.V. | 7,845,364 | 5,954,069 | -1,891,295 | 40.83 | 36.73 | -4.10 | sell |