| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 9,437,962 | 14,745,505 | +5,307,543 | 0.04 | 0.09 | +0.04 | buy |
| VANGUARD GROUP INC | 7,651,157 | 9,760,414 | +2,109,257 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 8,078,428 | 9,634,909 | +1,556,481 | 0.00 | 0.00 | +0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 9,130,465 | 9,130,465 | 0 | 13.12 | 15.35 | +2.22 | hold |
| FCPM III SERVICES B.V. | 5,462,846 | 5,462,846 | 0 | 14.09 | 13.81 | -0.28 | hold |
| FMR LLC | 5,293,369 | 5,401,916 | +108,547 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,355,678 | 5,268,917 | +1,913,239 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 4,836,437 | 4,729,174 | -107,263 | 2.38 | 2.34 | -0.04 | sell |
| TCG Crossover Management, LLC | 3,766,660 | 4,615,144 | +848,484 | 4.10 | 2.87 | -1.22 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,191,000 | 3,554,000 | +363,000 | 0.05 | 0.07 | +0.02 | buy |
| CITADEL ADVISORS LLC | 943,874 | 3,413,435 | +2,469,561 | 0.01 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 3,086,779 | 3,365,245 | +278,466 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,560,000 | 3,064,000 | +504,000 | 0.92 | 1.22 | +0.29 | buy |
| MARSHALL WACE, LLP | 447,807 | 3,013,377 | +2,565,570 | 0.01 | 0.04 | +0.04 | buy |
| RTW INVESTMENTS, LP | 1,690,567 | 2,890,567 | +1,200,000 | 0.23 | 0.45 | +0.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,253,670 | 2,867,605 | +613,935 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,793,590 | 2,812,422 | +1,018,832 | 0.01 | 0.02 | +0.01 | buy |
| Vestal Point Capital, LP | 727,500 | 2,775,000 | +2,047,500 | 0.36 | 1.59 | +1.23 | buy |
| BRAIDWELL LP | 3,273,349 | 2,730,481 | -542,868 | 1.07 | 1.02 | -0.04 | sell |
| Frazier Life Sciences Management, L.P. | 1,505,984 | 2,718,105 | +1,212,121 | 0.57 | 1.03 | +0.46 | buy |
| Saturn V Capital Management LP | 1,455,429 | 2,674,469 | +1,219,040 | 5.62 | 7.42 | +1.80 | buy |
| Vivo Capital, LLC | 1,114,960 | 2,614,960 | +1,500,000 | 1.09 | 2.66 | +1.58 | buy |
| Logos Global Management LP | 1,900,000 | 2,400,000 | +500,000 | 2.42 | 3.00 | +0.58 | buy |
| ORBIMED ADVISORS LLC | 1,031,400 | 2,314,184 | +1,282,784 | 0.25 | 0.70 | +0.46 | buy |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 1.55 | 1.55 | -0.00 | hold |
| Deep Track Capital, LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.71 | +0.71 | buy |
| GOLDMAN SACHS GROUP INC | 1,340,443 | 1,900,215 | +559,772 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,898,950 | +1,898,950 | 0.00 | 0.71 | +0.71 | buy |
| Point72 Asset Management, L.P. | 123,284 | 1,717,807 | +1,594,523 | 0.00 | 0.05 | +0.04 | buy |
| MPM BioImpact LLC | 1,446,361 | 1,446,361 | 0 | 2.39 | 3.00 | +0.61 | hold |
| MORGAN STANLEY | 1,362,176 | 1,419,007 | +56,831 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,390,140 | 1,398,530 | +8,390 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,383,953 | 1,398,087 | -985,866 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 264,976 | 1,262,674 | +997,698 | 0.54 | 2.96 | +2.42 | buy |
| NORTHERN TRUST CORP | 841,037 | 1,037,568 | +196,531 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 745,071 | 1,007,194 | +262,123 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 614,865 | 985,828 | +370,963 | 0.40 | 0.77 | +0.37 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 789,425 | 910,919 | +121,494 | 0.07 | 0.10 | +0.03 | buy |
| Candriam S.C.A. | 524,161 | 833,922 | +309,761 | 0.03 | 0.06 | +0.03 | buy |
| Qube Research & Technologies Ltd | 791,987 | 829,769 | +37,782 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 580,998 | 824,061 | +243,063 | 0.34 | 0.61 | +0.26 | buy |
| Integral Health Asset Management, LLC | 0 | 800,000 | +800,000 | 0.00 | 0.74 | +0.74 | buy |
| ArrowMark Colorado Holdings LLC | 770,225 | 785,915 | +15,690 | 0.13 | 0.18 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 513,801 | 761,112 | +247,311 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 729,606 | +729,606 | 0.00 | 0.04 | +0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 791,120 | 710,044 | -81,076 | 0.03 | 0.03 | +0.00 | sell |
| Nantahala Capital Management, LLC | 745,062 | 702,884 | -42,178 | 0.50 | 0.55 | +0.05 | sell |
| MPM ASSET MANAGEMENT LLC | 682,376 | 682,376 | 0 | 14.99 | 19.40 | +4.41 | hold |
| Jain Global LLC | 596,167 | 644,082 | +47,915 | 0.09 | 0.11 | +0.02 | buy |
| Aberdeen Group plc | 483,963 | 556,733 | +72,770 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 374,969 | 543,166 | +168,197 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,247,390 | 540,444 | -1,706,946 | 0.80 | 0.20 | -0.61 | sell |
| Polar Capital Holdings Plc | 0 | 529,388 | +529,388 | 0.00 | 0.03 | +0.03 | buy |
| WASATCH ADVISORS LP | 557,937 | 523,924 | -34,013 | 0.03 | 0.04 | +0.01 | sell |
| University of Wisconsin Foundation | 0 | 517,750 | +517,750 | 0.00 | 5.55 | +5.55 | buy |
| ALGERT GLOBAL LLC | 558,896 | 515,132 | -43,764 | 0.11 | 0.11 | -0.00 | sell |
| BARCLAYS PLC | 320,490 | 480,701 | +160,211 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 474,612 | +474,612 | 0.00 | 1.21 | +1.21 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 221,416 | 426,518 | +205,102 | 0.55 | 1.28 | +0.73 | buy |
| AMERIPRISE FINANCIAL INC | 285,004 | 422,656 | +137,652 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 333,453 | 415,927 | +82,474 | 0.02 | 0.04 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 142,719 | 413,940 | +271,221 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 121,792 | 349,388 | +227,596 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 345,500 | +345,500 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 362,310 | 345,462 | -16,848 | 0.04 | 0.05 | +0.01 | sell |
| Nuveen, LLC | 199,831 | 344,897 | +145,066 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 200,266 | 321,426 | +121,160 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 269,664 | 317,364 | +47,700 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 284,000 | +284,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 128,962 | 281,340 | +152,378 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 205,626 | 275,596 | +69,970 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 293,644 | 229,430 | -64,214 | 0.00 | 0.00 | +0.00 | sell |
| TFG Asset Management GP Ltd | 138,375 | 223,181 | +84,806 | 0.24 | 0.41 | +0.17 | buy |
| Rafferty Asset Management, LLC | 110,248 | 213,211 | +102,963 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 385,248 | 201,240 | -184,008 | 0.21 | 0.16 | -0.05 | sell |
| Swiss National Bank | 140,400 | 178,300 | +37,900 | 0.00 | 0.00 | +0.00 | buy |
| Darwin Wealth Management, LLC | 172,656 | 173,517 | +861 | 0.57 | 0.70 | +0.13 | buy |
| RHUMBLINE ADVISERS | 154,541 | 167,820 | +13,279 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 42,910 | 141,875 | +98,965 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 277,259 | 136,385 | -140,874 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 118,961 | 132,900 | +13,939 | 0.05 | 0.07 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 318,653 | 125,886 | -192,767 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 0 | 120,000 | +120,000 | 0.00 | 0.09 | +0.09 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 186,015 | 117,770 | -68,245 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 82,142 | 117,563 | +35,421 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 197,148 | 115,341 | -81,807 | 0.04 | 0.06 | +0.02 | sell |
| Russell Investments Group, Ltd. | 43,925 | 113,932 | +70,007 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 363,837 | 113,837 | -250,000 | 1.15 | 0.29 | -0.85 | sell |
| Voleon Capital Management LP | 44,723 | 111,838 | +67,115 | 0.02 | 0.03 | +0.01 | buy |
| Legal & General Group Plc | 78,533 | 107,975 | +29,442 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 98,240 | 106,680 | +8,440 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 172,469 | 102,991 | -69,478 | 0.02 | 0.01 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.18 | +0.18 | buy |
| Jump Financial, LLC | 0 | 99,884 | +99,884 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 53,174 | 98,701 | +45,527 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 101,612 | 89,160 | -12,452 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 56,705 | 87,121 | +30,416 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 75,338 | 86,496 | +11,158 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 78,072 | +78,072 | 0.00 | 0.04 | +0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 51,480 | 76,912 | +25,432 | 0.00 | 0.00 | +0.00 | buy |