| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 815,085 | 1,217,960 | +402,875 | 0.31 | 0.54 | +0.23 | buy |
| Sofinnova Investments, Inc. | 685,133 | 1,013,505 | +328,372 | 0.39 | 0.75 | +0.37 | buy |
| Octagon Capital Advisors LP | 692,945 | 792,945 | +100,000 | 1.09 | 1.69 | +0.59 | buy |
| Woodline Partners LP | 335,884 | 435,526 | +99,642 | 0.04 | 0.06 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 110,752 | 57,330 | +53,422 | 0.03 | 0.06 | 0.00 | sell |
| Candriam S.C.A. | 723,624 | 763,624 | +40,000 | 0.05 | 0.07 | +0.02 | buy |
| Rafferty Asset Management, LLC | 139,409 | 164,041 | +24,632 | 0.01 | 0.01 | +0.00 | buy |
| Belvedere Trading LLC | 16,058 | 34,744 | +18,686 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,558 | 7,099 | +5,541 | 0.00 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 23,793 | 26,962 | +3,169 | 0.01 | 0.02 | 0.00 | buy |
| ALGERT GLOBAL LLC | 158,713 | 161,004 | +2,291 | 0.07 | 0.09 | 0.00 | buy |
| Quarry LP | 3,200 | 1,500 | +1,700 | 0.02 | 0.01 | 0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 146,500 | 147,836 | +1,336 | 0.88 | 1.11 | +0.23 | buy |
| B. Metzler seel. Sohn & Co. AG | 18,973 | 19,962 | +989 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,972 | 7,833 | -139 | 0.04 | 0.07 | +0.02 | sell |
| Redmond Asset Management, LLC | 13,216 | 12,500 | -716 | 0.04 | 0.05 | +0.01 | sell |
| WASATCH ADVISORS LP | 1,687,802 | 1,684,517 | -3,285 | 0.10 | 0.12 | +0.03 | sell |
| Nantahala Capital Management, LLC | 683,164 | 642,789 | -40,375 | 0.52 | 0.51 | -0.01 | sell |
| Vida Ventures Advisors, LLC | 2,220,034 | 2,074,787 | -145,247 | 30.79 | 32.85 | +2.06 | sell |
| Logos Global Management LP | 2,180,000 | 1,880,000 | -300,000 | 2.79 | 2.78 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 1,200,000 | 824,000 | -376,000 | 0.16 | 0.15 | -0.02 | sell |
| Deep Track Capital, LP | 2,403,672 | 2,000,000 | -403,672 | 0.84 | 0.93 | +0.10 | sell |
| BRAIDWELL LP | 1,821,972 | 755,811 | -1,066,161 | 0.52 | 0.37 | -0.15 | sell |