| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 107,742 | 2,021,395 | +1,913,653 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,184,840 | +1,184,840 | 0.00 | 0.84 | +0.84 | buy |
| Commodore Capital LP | 0 | 900,000 | +900,000 | 0.00 | 1.05 | +1.05 | buy |
| FMR LLC | 846,360 | 1,282,812 | +436,452 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 815,085 | 1,217,960 | +402,875 | 0.32 | 0.55 | +0.23 | buy |
| Laurion Capital Management LP | 0 | 400,000 | +400,000 | 0.00 | 0.19 | +0.19 | buy |
| STATE STREET CORP | 1,938,642 | 2,337,141 | +398,499 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 388,090 | +388,090 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 375,000 | +375,000 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 685,133 | 1,013,505 | +328,372 | 0.43 | 0.76 | +0.33 | buy |
| Ikarian Capital, LLC | 0 | 285,900 | +285,900 | 0.00 | 1.04 | +1.04 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 275,699 | +275,699 | 0.00 | 0.03 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 0 | 202,871 | +202,871 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 187,288 | +187,288 | 0.00 | 0.27 | +0.27 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 137,751 | +137,751 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 692,945 | 792,945 | +100,000 | 1.09 | 1.69 | +0.59 | buy |
| Woodline Partners LP | 335,884 | 435,526 | +99,642 | 0.04 | 0.06 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 857,710 | 932,838 | +75,128 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 476,026 | 550,324 | +74,298 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 54,158 | 124,050 | +69,892 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 57,200 | +57,200 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 99,574 | 153,351 | +53,777 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 53,344 | +53,344 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 723,624 | 763,624 | +40,000 | 0.05 | 0.07 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 115,935 | 145,474 | +29,539 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 250,986 | 280,114 | +29,128 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 394,251 | 423,085 | +28,834 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 139,409 | 164,041 | +24,632 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 24,511 | +24,511 | 0.00 | 0.07 | +0.07 | buy |
| Trexquant Investment LP | 0 | 22,822 | +22,822 | 0.00 | 0.01 | +0.01 | buy |
| Belvedere Trading LLC | 16,058 | 34,744 | +18,686 | 0.02 | 0.04 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 18,500 | +18,500 | 0.00 | 0.02 | +0.02 | buy |
| GROUP ONE TRADING LLC | 60,334 | 78,620 | +18,286 | 0.02 | 0.03 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 14,434 | +14,434 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,222 | 25,389 | +13,167 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 157,443 | 170,560 | +13,117 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 12,938 | +12,938 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,041,606 | 3,053,440 | +11,834 | 0.03 | 0.04 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 11,279 | +11,279 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 61,895 | 71,604 | +9,709 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 325,371 | 331,568 | +6,197 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 70,571 | 76,238 | +5,667 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,558 | 7,099 | +5,541 | 0.00 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 23,793 | 26,962 | +3,169 | 0.01 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 158,713 | 161,004 | +2,291 | 0.07 | 0.09 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,348 | 18,592 | +2,244 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 146,500 | 147,836 | +1,336 | 0.95 | 1.11 | +0.15 | buy |
| Mirae Asset Global Investments Co., Ltd. | 21,722 | 22,921 | +1,199 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,510 | 4,605 | +1,095 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 18,973 | 19,962 | +989 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 21,212 | 22,111 | +899 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 1,912,956 | 1,913,832 | +876 | 0.01 | 0.01 | +0.00 | buy |
| SIGNATUREFD, LLC | 111 | 579 | +468 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 231 | +231 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 230 | +230 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 24,092 | 24,274 | +182 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 4,299 | 4,460 | +161 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 61 | 79 | +18 | 0.00 | 0.00 | +0.00 | buy |
| MPM ASSET MANAGEMENT LLC | 4,951,303 | 4,951,303 | 0 | 23.76 | 32.36 | +8.60 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,379 | 8,379 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 511,293 | 511,293 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 210 | 210 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 382,416 | 382,416 | 0 | 0.04 | 0.06 | +0.01 | hold |
| MetLife Investment Management, LLC | 22,933 | 22,933 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 2.05 | 1.98 | -0.07 | hold |
| Vivo Capital, LLC | 1,035,136 | 1,035,136 | 0 | 1.02 | 1.13 | +0.11 | hold |
| Truvestments Capital LLC | 464 | 464 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TCG Crossover Management, LLC | 1,650,150 | 1,650,150 | 0 | 2.18 | 2.43 | +0.26 | hold |
| Washington Trust Advisors, Inc. | 125 | 125 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 9,885,449 | 9,885,449 | 0 | 13.72 | 15.66 | +1.94 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,376 | 2,376 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 175 | 175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,215 | 12,215 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 11,364 | 11,330 | -34 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 35 | 0 | -35 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 90 | 0 | -90 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 7,972 | 7,833 | -139 | 0.04 | 0.07 | +0.02 | sell |
| Spire Wealth Management | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 21,423 | 20,901 | -522 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 21,123 | 20,461 | -662 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 15,229 | 14,546 | -683 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,152 | 34,467 | -685 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 30,906 | 30,210 | -696 | 0.00 | 0.00 | +0.00 | sell |
| Redmond Asset Management, LLC | 13,216 | 12,500 | -716 | 0.04 | 0.05 | +0.01 | sell |
| Tower Research Capital LLC (TRC) | 7,989 | 6,795 | -1,194 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 3,200 | 1,500 | -1,700 | 0.02 | 0.01 | -0.01 | sell |
| WASATCH ADVISORS LP | 1,687,802 | 1,684,517 | -3,285 | 0.10 | 0.12 | +0.03 | sell |
| Swiss National Bank | 63,500 | 60,200 | -3,300 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 27,407 | 22,680 | -4,727 | 0.00 | 0.00 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 9,310 | 2,318 | -6,992 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,129 | 17,329 | -7,800 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,644 | 0 | -11,644 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 17,646 | 0 | -17,646 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 36,032 | 18,061 | -17,971 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 94,395 | 75,172 | -19,223 | 0.00 | 0.00 | +0.00 | sell |
| Corton Capital Inc. | 19,926 | 0 | -19,926 | 0.09 | 0.00 | -0.09 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 20,938 | 0 | -20,938 | 0.03 | 0.00 | -0.03 | sell |