| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 6,813,163 | 7,379,309 | +566,146 | 0.13 | 0.09 | 0.00 | buy |
| ORBIMED ADVISORS LLC | 708,400 | 1,227,080 | +518,680 | 0.47 | 0.60 | +0.13 | buy |
| Octagon Capital Advisors LP | 262,726 | 668,000 | +405,274 | 1.51 | 2.68 | +1.17 | buy |
| Holocene Advisors, LP | 1,982,640 | 2,348,161 | +365,521 | 0.29 | 0.18 | -0.11 | buy |
| Sofinnova Investments, Inc. | 772,070 | 1,071,498 | +299,428 | 2.20 | 1.84 | -0.36 | buy |
| Logos Global Management LP | 160,000 | 450,000 | +290,000 | 0.62 | 1.24 | +0.62 | buy |
| Siren, L.L.C. | 1,134,664 | 1,347,456 | +212,792 | 2.04 | 1.40 | -0.64 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 56,504 | 236,262 | +179,758 | 0.32 | 1.01 | +0.68 | buy |
| Crestline Management, LP | 117,681 | 184,818 | +67,137 | 0.22 | 0.14 | -0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 90,041 | 147,002 | +56,961 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 17,310 | 57,755 | +40,445 | 0.16 | 0.33 | +0.17 | buy |
| ArrowMark Colorado Holdings LLC | 900,190 | 932,231 | +32,041 | 0.41 | 0.30 | -0.12 | buy |
| ALGERT GLOBAL LLC | 94,960 | 80,923 | +14,037 | 0.09 | 0.05 | 0.00 | sell |
| Rock Springs Capital Management LP | 461,028 | 474,528 | +13,500 | 0.54 | 0.43 | -0.11 | buy |
| HighVista Strategies LLC | 65,482 | 78,420 | +12,938 | 0.81 | 0.69 | -0.12 | buy |
| Candriam S.C.A. | 390,956 | 401,395 | +10,439 | 0.08 | 0.05 | -0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 19,318 | 12,584 | +6,734 | 0.05 | 0.02 | 0.00 | sell |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 38,614 | 44,940 | +6,326 | 0.23 | 0.17 | -0.06 | buy |
| Privium Fund Management B.V. | 15,016 | 20,366 | +5,350 | 0.13 | 0.11 | -0.03 | buy |
| Rafferty Asset Management, LLC | 164,962 | 167,482 | +2,520 | 0.02 | 0.01 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 19,310 | 21,575 | +2,265 | 0.08 | 0.05 | -0.03 | buy |
| E Fund Management Co., Ltd. | 10,599 | 11,848 | +1,249 | 0.02 | 0.01 | -0.01 | buy |
| PROFUND ADVISORS LLC | 32,892 | 32,594 | +298 | 0.05 | 0.03 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,736 | 2,776 | +40 | 0.05 | 0.03 | -0.02 | buy |
| Atlas Venture Life Science Advisors, LLC | 8,020,136 | 8,019,354 | -782 | 26.71 | 23.05 | -3.66 | sell |
| WASATCH ADVISORS LP | 324,099 | 320,626 | -3,473 | 0.06 | 0.04 | -0.02 | sell |
| OPPENHEIMER & CO INC | 40,091 | 34,715 | -5,376 | 0.02 | 0.01 | -0.01 | sell |
| FORA Capital, LLC | 18,180 | 9,235 | -8,945 | 0.08 | 0.02 | -0.05 | sell |
| Avidity Partners Management LP | 165,000 | 96,000 | -69,000 | 0.30 | 0.22 | -0.08 | sell |
| Candriam S.C.A. | 533,273 | 401,395 | -131,878 | 0.11 | 0.05 | -0.06 | sell |
| JENNISON ASSOCIATES LLC | 1,346,952 | 1,211,915 | -135,037 | 0.03 | 0.02 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 718,144 | 543,277 | -174,867 | 0.55 | 0.35 | -0.19 | sell |
| ARMISTICE CAPITAL, LLC | 1,155,204 | 964,518 | -190,686 | 0.66 | 0.31 | -0.35 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,636,293 | 2,402,452 | -233,841 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 977,440 | 573,957 | -403,483 | 0.30 | 0.09 | -0.20 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,402,972 | 1,950,000 | -452,972 | 0.15 | 0.08 | -0.07 | sell |
| FCPM III SERVICES B.V. | 5,954,069 | 5,462,846 | -491,223 | 36.73 | 21.73 | -15.00 | sell |
| First Light Asset Management, LLC | 1,257,285 | 420,431 | -836,854 | 3.76 | 0.95 | -2.81 | sell |
| Deep Track Capital, LP | 3,282,000 | 2,000,000 | -1,282,000 | 3.76 | 1.77 | -2.00 | sell |
| RTW INVESTMENTS, LP | 6,818,641 | 5,218,641 | -1,600,000 | 3.54 | 1.86 | -1.68 | sell |