| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Jefferies Financial Group Inc. | 0 | 1,800,000 | +1,800,000 | 0.00 | 0.47 | +0.47 | buy |
| Point72 Asset Management, L.P. | 102,480 | 924,681 | +822,201 | 0.01 | 0.06 | +0.05 | buy |
| BRAIDWELL LP | 0 | 681,182 | +681,182 | 0.00 | 0.48 | +0.48 | buy |
| JANUS HENDERSON GROUP PLC | 6,813,163 | 7,379,309 | +566,146 | 0.13 | 0.09 | -0.04 | buy |
| ORBIMED ADVISORS LLC | 708,400 | 1,227,080 | +518,680 | 0.47 | 0.60 | +0.13 | buy |
| NORGES BANK | 432,327 | 950,104 | +517,777 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 262,726 | 668,000 | +405,274 | 1.51 | 2.68 | +1.17 | buy |
| Holocene Advisors, LP | 1,982,640 | 2,348,161 | +365,521 | 0.29 | 0.18 | -0.11 | buy |
| Sofinnova Investments, Inc. | 772,070 | 1,071,498 | +299,428 | 2.30 | 1.85 | -0.44 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 298,052 | +298,052 | 0.00 | 0.07 | +0.07 | buy |
| Logos Global Management LP | 160,000 | 450,000 | +290,000 | 0.64 | 1.24 | +0.60 | buy |
| Qube Research & Technologies Ltd | 23,166 | 267,377 | +244,211 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 1,134,664 | 1,347,456 | +212,792 | 2.04 | 1.40 | -0.64 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 56,504 | 236,262 | +179,758 | 0.33 | 1.03 | +0.70 | buy |
| BlackRock, Inc. | 7,794,114 | 7,949,402 | +155,288 | 0.01 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.31 | +0.31 | buy |
| Cubist Systematic Strategies, LLC | 0 | 119,065 | +119,065 | 0.00 | 0.05 | +0.05 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 119,015 | +119,015 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 64,438 | 142,917 | +78,479 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,641,859 | 3,717,383 | +75,524 | 0.01 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 73,150 | +73,150 | 0.00 | 1.51 | +1.51 | buy |
| Crestline Management, LP | 117,681 | 184,818 | +67,137 | 0.24 | 0.15 | -0.09 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 66,998 | +66,998 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 64,090 | 125,378 | +61,288 | 0.03 | 0.03 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 73,040 | 133,772 | +60,732 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 90,041 | 147,002 | +56,961 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 721,502 | 777,013 | +55,511 | 0.00 | 0.00 | -0.00 | buy |
| Darwin Wealth Management, LLC | 0 | 52,090 | +52,090 | 0.00 | 0.41 | +0.41 | buy |
| Jump Financial, LLC | 0 | 50,911 | +50,911 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,869 | 79,514 | +46,645 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 17,310 | 57,755 | +40,445 | 0.16 | 0.33 | +0.17 | buy |
| COMERICA BANK | 175 | 35,409 | +35,234 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 900,190 | 932,231 | +32,041 | 0.41 | 0.30 | -0.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 5,991 | 37,536 | +31,545 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 30,537 | 61,348 | +30,811 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 28,781 | +28,781 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,859,413 | 1,887,329 | +27,916 | 0.01 | 0.00 | -0.00 | buy |
| Man Group plc | 718,650 | 746,463 | +27,813 | 0.07 | 0.05 | -0.02 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 26,816 | +26,816 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 25,803 | +25,803 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 24,501 | +24,501 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 46,857 | 70,961 | +24,104 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 104,517 | 128,290 | +23,773 | 0.01 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 22,702 | +22,702 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 55,103 | 74,378 | +19,275 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 304,705 | 323,552 | +18,847 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 648,652 | 667,452 | +18,800 | 0.00 | 0.00 | -0.00 | buy |
| SYON CAPITAL LLC | 0 | 16,930 | +16,930 | 0.00 | 0.04 | +0.04 | buy |
| HRT FINANCIAL LP | 0 | 16,722 | +16,722 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 60,700 | 76,100 | +15,400 | 0.01 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 137,066 | 152,306 | +15,240 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,622 | 16,018 | +14,396 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 25,077 | 38,754 | +13,677 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 461,028 | 474,528 | +13,500 | 0.54 | 0.43 | -0.11 | buy |
| HighVista Strategies LLC | 65,482 | 78,420 | +12,938 | 0.81 | 0.69 | -0.12 | buy |
| Magnetar Financial LLC | 0 | 11,181 | +11,181 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 390,956 | 401,395 | +10,439 | 0.08 | 0.05 | -0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 134,334 | 143,363 | +9,029 | 0.00 | 0.00 | -0.00 | buy |
| Neo Ivy Capital Management | 0 | 8,715 | +8,715 | 0.00 | 0.04 | +0.04 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,814 | 33,976 | +8,162 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 21,182 | 28,044 | +6,862 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 212,900 | 219,635 | +6,735 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,333 | 15,751 | +6,418 | 0.00 | 0.00 | +0.00 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 38,614 | 44,940 | +6,326 | 0.23 | 0.17 | -0.06 | buy |
| Point72 (DIFC) Ltd | 992 | 6,420 | +5,428 | 0.00 | 0.01 | +0.01 | buy |
| Privium Fund Management B.V. | 15,016 | 20,366 | +5,350 | 0.13 | 0.11 | -0.03 | buy |
| HSBC HOLDINGS PLC | 9,176 | 13,354 | +4,178 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 124,510 | 128,244 | +3,734 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 105,100 | 108,600 | +3,500 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 19,300 | 22,500 | +3,200 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,677 | 53,580 | +2,903 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,502 | 16,385 | +2,883 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 312,752 | 315,602 | +2,850 | 0.02 | 0.01 | -0.01 | buy |
| MetLife Investment Management, LLC | 46,719 | 49,467 | +2,748 | 0.01 | 0.01 | -0.00 | buy |
| Rafferty Asset Management, LLC | 164,962 | 167,482 | +2,520 | 0.02 | 0.01 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 19,310 | 21,575 | +2,265 | 0.08 | 0.05 | -0.03 | buy |
| E Fund Management Co., Ltd. | 10,599 | 11,848 | +1,249 | 0.02 | 0.01 | -0.01 | buy |
| KBC Group NV | 2,157 | 3,135 | +978 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,882 | 53,635 | +753 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,906 | 8,627 | +721 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 234,100 | 234,798 | +698 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 18,344 | 19,036 | +692 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 613 | +613 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 15,502 | 16,020 | +518 | 0.00 | 0.00 | -0.00 | buy |
| Spire Wealth Management | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Venturi Wealth Management, LLC | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,368 | 1,609 | +241 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 375 | 610 | +235 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 237 | 280 | +43 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,736 | 2,776 | +40 | 0.05 | 0.03 | -0.02 | buy |
| Amundi | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 435,653 | 435,653 | 0 | 0.23 | 0.20 | -0.04 | hold |
| MPM ASSET MANAGEMENT LLC | 682,376 | 682,376 | 0 | 16.87 | 12.92 | -3.95 | hold |
| BAKER BROS. ADVISORS LP | 672,096 | 672,096 | 0 | 0.25 | 0.17 | -0.08 | hold |