| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 2,812,422 | 17,540,089 | +14,727,667 | 0.02 | 0.22 | +0.19 | buy |
| JANUS HENDERSON GROUP PLC | 14,745,505 | 13,887,722 | -857,783 | 0.09 | 0.12 | +0.04 | sell |
| VANGUARD GROUP INC | 9,760,414 | 11,215,565 | +1,455,151 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 9,634,909 | 11,190,838 | +1,555,929 | 0.00 | 0.00 | +0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 9,130,465 | 9,130,465 | 0 | 15.35 | 20.64 | +5.30 | hold |
| STATE STREET CORP | 5,268,917 | 6,692,745 | +1,423,828 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,401,916 | 6,569,921 | +1,168,005 | 0.00 | 0.01 | +0.00 | buy |
| FCPM III SERVICES B.V. | 5,462,846 | 5,462,846 | 0 | 13.81 | 14.01 | +0.20 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,554,000 | 5,172,000 | +1,618,000 | 0.07 | 0.15 | +0.08 | buy |
| Orbis Allan Gray Ltd | 0 | 4,801,928 | +4,801,928 | 0.00 | 0.39 | +0.39 | buy |
| TCG Crossover Management, LLC | 4,615,144 | 4,615,144 | 0 | 2.87 | 2.99 | +0.12 | hold |
| JPMORGAN CHASE & CO | 3,365,245 | 3,549,909 | +184,664 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 4,729,174 | 3,502,941 | -1,226,233 | 2.34 | 2.04 | -0.30 | sell |
| PERCEPTIVE ADVISORS LLC | 540,444 | 3,478,944 | +2,938,500 | 0.20 | 1.25 | +1.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,867,605 | 3,263,429 | +395,824 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 3,064,000 | 3,249,708 | +185,708 | 1.22 | 1.56 | +0.34 | buy |
| Frazier Life Sciences Management, L.P. | 2,718,105 | 3,153,082 | +434,977 | 1.03 | 1.66 | +0.63 | buy |
| Deep Track Capital, LP | 2,000,000 | 2,650,000 | +650,000 | 0.71 | 1.18 | +0.48 | buy |
| Vivo Capital, LLC | 2,614,960 | 2,614,960 | 0 | 2.66 | 3.31 | +0.64 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,398,087 | 2,323,789 | +925,702 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,900,215 | 2,283,191 | +382,976 | 0.00 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 985,828 | 2,254,161 | +1,268,333 | 0.77 | 1.90 | +1.14 | buy |
| ORBIMED ADVISORS LLC | 2,314,184 | 2,202,184 | -112,000 | 0.70 | 0.88 | +0.18 | sell |
| VR Adviser, LLC | 2,173,913 | 2,173,913 | 0 | 1.55 | 2.10 | +0.55 | hold |
| FRANKLIN RESOURCES INC | 1,398,530 | 2,006,638 | +608,108 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 2,674,469 | 1,788,616 | -885,853 | 7.42 | 6.42 | -1.00 | sell |
| SAMLYN CAPITAL, LLC | 0 | 1,493,075 | +1,493,075 | 0.00 | 0.47 | +0.47 | buy |
| BRAIDWELL LP | 2,730,481 | 1,478,329 | -1,252,152 | 1.02 | 0.92 | -0.10 | sell |
| Palo Alto Investors LP | 1,262,674 | 1,472,197 | +209,523 | 2.96 | 4.01 | +1.05 | buy |
| MPM BioImpact LLC | 1,446,361 | 1,405,388 | -40,973 | 3.00 | 3.15 | +0.15 | sell |
| Polar Capital Holdings Plc | 529,388 | 1,269,131 | +739,743 | 0.03 | 0.11 | +0.08 | buy |
| Logos Global Management LP | 2,400,000 | 1,250,000 | -1,150,000 | 3.00 | 1.63 | -1.37 | sell |
| MORGAN STANLEY | 1,419,007 | 1,213,559 | -205,448 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 3,413,435 | 1,171,624 | -2,241,811 | 0.03 | 0.02 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,007,194 | 1,151,325 | +144,131 | 0.00 | 0.00 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 910,919 | 1,138,868 | +227,949 | 0.10 | 0.24 | +0.13 | buy |
| Aberdeen Group plc | 556,733 | 1,108,145 | +551,412 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 1,037,568 | 1,092,191 | +54,623 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 833,922 | 1,057,263 | +223,341 | 0.06 | 0.10 | +0.05 | buy |
| Rock Springs Capital Management LP | 824,061 | 912,955 | +88,894 | 0.61 | 0.92 | +0.31 | buy |
| MILLENNIUM MANAGEMENT LLC | 413,940 | 904,389 | +490,449 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 761,112 | 882,922 | +121,810 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 474,612 | 835,200 | +360,588 | 1.21 | 2.80 | +1.59 | buy |
| BAKER BROS. ADVISORS LP | 0 | 813,449 | +813,449 | 0.00 | 0.09 | +0.09 | buy |
| ArrowMark Colorado Holdings LLC | 785,915 | 700,653 | -85,262 | 0.18 | 0.30 | +0.12 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 680,305 | +680,305 | 0.00 | 0.21 | +0.21 | buy |
| MARSHALL WACE, LLP | 3,013,377 | 676,979 | -2,336,398 | 0.04 | 0.01 | -0.03 | sell |
| Artisan Partners Limited Partnership | 0 | 649,691 | +649,691 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 344,897 | 621,310 | +276,413 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 76,912 | 530,338 | +453,426 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 519,715 | +519,715 | 0.00 | 1.80 | +1.80 | buy |
| Ensign Peak Advisors, Inc | 20,150 | 496,590 | +476,440 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 345,500 | 470,645 | +125,145 | 0.01 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 464,797 | +464,797 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 480,701 | 448,658 | -32,043 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 432,986 | +432,986 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 20,382 | 419,756 | +399,374 | 0.00 | 0.01 | +0.01 | buy |
| University of Wisconsin Foundation | 517,750 | 416,750 | -101,000 | 5.55 | 6.85 | +1.31 | sell |
| Qube Research & Technologies Ltd | 829,769 | 412,440 | -417,329 | 0.01 | 0.01 | -0.00 | sell |
| Clearbridge Investments, LLC | 0 | 407,794 | +407,794 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 523,924 | 406,960 | -116,964 | 0.04 | 0.05 | +0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 426,518 | 392,894 | -33,624 | 1.28 | 1.61 | +0.33 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 275,596 | 386,953 | +111,357 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 349,388 | 380,978 | +31,590 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 317,364 | 353,497 | +36,133 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 343,726 | +343,726 | 0.00 | 0.15 | +0.15 | buy |
| Point72 Asset Management, L.P. | 1,717,807 | 329,345 | -1,388,462 | 0.05 | 0.01 | -0.04 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 284,000 | 284,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALGERT GLOBAL LLC | 515,132 | 271,303 | -243,829 | 0.11 | 0.08 | -0.03 | sell |
| SG Americas Securities, LLC | 0 | 265,384 | +265,384 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 47,592 | 255,160 | +207,568 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 0 | 250,065 | +250,065 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 223,181 | 247,997 | +24,816 | 0.41 | 1.02 | +0.61 | buy |
| SummitTX Capital, L.P. | 132,900 | 243,276 | +110,376 | 0.07 | 0.14 | +0.07 | buy |
| Neo Ivy Capital Management | 0 | 237,467 | +237,467 | 0.00 | 0.73 | +0.73 | buy |
| Rafferty Asset Management, LLC | 213,211 | 233,835 | +20,624 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 113,932 | 232,013 | +118,081 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 178,300 | 222,500 | +44,200 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 229,430 | 214,491 | -14,939 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 422,656 | 197,691 | -224,965 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 125,886 | 196,080 | +70,194 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 201,240 | 182,986 | -18,254 | 0.16 | 0.23 | +0.07 | sell |
| RHUMBLINE ADVISERS | 167,820 | 175,020 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 31,385 | 168,304 | +136,919 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 846 | 165,692 | +164,846 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 321,426 | 165,482 | -155,944 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 644,082 | 162,047 | -482,035 | 0.11 | 0.03 | -0.07 | sell |
| Brevan Howard Capital Management LP | 59,302 | 157,969 | +98,667 | 0.01 | 0.06 | +0.05 | buy |
| First Light Asset Management, LLC | 0 | 155,231 | +155,231 | 0.00 | 0.23 | +0.23 | buy |
| Burkehill Global Management, LP | 120,000 | 155,000 | +35,000 | 0.09 | 0.20 | +0.11 | buy |
| Lisanti Capital Growth, LLC | 0 | 154,445 | +154,445 | 0.00 | 0.72 | +0.72 | buy |
| WELLS FARGO & COMPANY/MN | 87,121 | 147,831 | +60,710 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 147,621 | +147,621 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 117,563 | 137,684 | +20,121 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 106,680 | 134,260 | +27,580 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,160 | 120,800 | +31,640 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 120,788 | +120,788 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 2,775,000 | 120,000 | -2,655,000 | 1.59 | 0.09 | -1.51 | sell |
| Legal & General Group Plc | 107,975 | 118,122 | +10,147 | 0.00 | 0.00 | +0.00 | buy |
| Darwin Wealth Management, LLC | 173,517 | 115,267 | -58,250 | 0.70 | 0.70 | +0.00 | sell |