| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 2,812,422 | 17,540,089 | +14,727,667 | 0.02 | 0.22 | +0.19 | buy |
| PERCEPTIVE ADVISORS LLC | 540,444 | 3,478,944 | +2,938,500 | 0.20 | 1.21 | +1.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,554,000 | 5,172,000 | +1,618,000 | 0.07 | 0.15 | +0.08 | buy |
| Sofinnova Investments, Inc. | 985,828 | 2,254,161 | +1,268,333 | 0.68 | 1.90 | +1.22 | buy |
| Polar Capital Holdings Plc | 529,388 | 1,269,131 | +739,743 | 0.03 | 0.11 | +0.08 | buy |
| Deep Track Capital, LP | 2,000,000 | 2,650,000 | +650,000 | 0.71 | 1.18 | +0.48 | buy |
| Aberdeen Group plc | 556,733 | 1,108,145 | +551,412 | 0.01 | 0.03 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 2,718,105 | 3,153,082 | +434,977 | 1.03 | 1.66 | +0.63 | buy |
| STEMPOINT CAPITAL LP | 474,612 | 835,200 | +360,588 | 1.21 | 2.80 | +1.59 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 910,919 | 1,138,868 | +227,949 | 0.10 | 0.24 | +0.13 | buy |
| Candriam S.C.A. | 833,922 | 1,057,263 | +223,341 | 0.06 | 0.10 | +0.05 | buy |
| Palo Alto Investors LP | 1,262,674 | 1,472,197 | +209,523 | 2.96 | 4.01 | +1.05 | buy |
| ARMISTICE CAPITAL, LLC | 3,064,000 | 3,249,708 | +185,708 | 0.57 | 0.76 | +0.18 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 275,596 | 386,953 | +111,357 | 0.00 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 132,900 | 243,276 | +110,376 | 0.07 | 0.14 | +0.07 | buy |
| Rock Springs Capital Management LP | 824,061 | 912,955 | +88,894 | 0.61 | 0.92 | +0.31 | buy |
| Headlands Technologies LLC | 12,699 | 75,235 | +62,536 | 0.01 | 0.12 | +0.11 | buy |
| PROFUND ADVISORS LLC | 45,980 | 86,746 | +40,766 | 0.02 | 0.05 | 0.00 | buy |
| Burkehill Global Management, LP | 120,000 | 155,000 | +35,000 | 0.09 | 0.20 | +0.11 | buy |
| Aegis Wealth Management LLC | 49,908 | 75,908 | +26,000 | 0.34 | 0.84 | +0.50 | buy |
| TFG Asset Management GP Ltd | 223,181 | 247,997 | +24,816 | 0.38 | 1.02 | +0.65 | buy |
| Rafferty Asset Management, LLC | 213,211 | 233,835 | +20,624 | 0.01 | 0.02 | +0.01 | buy |
| Lighthouse Investment Partners, LLC | 20,000 | 34,000 | +14,000 | 0.01 | 0.02 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 7,869 | 13,806 | +5,937 | 0.03 | 0.07 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 37,663 | 42,674 | +5,011 | 0.05 | 0.06 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 35,190 | 31,422 | +3,768 | 0.04 | 0.06 | 0.00 | sell |
| Optimize Financial Inc | 29,874 | 30,310 | +436 | 0.20 | 0.30 | +0.10 | buy |
| Chung Wu Investment Group, LLC | 2,400 | 2,800 | +400 | 0.03 | 0.04 | +0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,061 | 2,806 | -255 | 0.00 | 0.00 | +0.00 | sell |
| Aspect Partners, LLC | 605 | 225 | -380 | 0.00 | 0.00 | -0.00 | sell |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 49,225 | 47,875 | -1,350 | 0.10 | 0.15 | +0.06 | sell |
| China Universal Asset Management Co., Ltd. | 24,937 | 23,273 | -1,664 | 0.03 | 0.03 | +0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 27,050 | 25,152 | -1,898 | 0.01 | 0.01 | +0.00 | sell |
| Bridgefront Capital, LLC | 18,042 | 12,018 | -6,024 | 0.07 | 0.06 | -0.01 | sell |
| PDT Partners, LLC | 201,240 | 182,986 | -18,254 | 0.16 | 0.23 | +0.07 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 426,518 | 392,894 | -33,624 | 1.14 | 1.49 | +0.35 | sell |
| MPM BioImpact LLC | 1,446,361 | 1,405,388 | -40,973 | 3.00 | 3.15 | +0.15 | sell |
| WINTON GROUP Ltd | 78,072 | 21,296 | -56,776 | 0.04 | 0.01 | -0.02 | sell |
| Darwin Wealth Management, LLC | 173,517 | 115,267 | -58,250 | 0.70 | 0.70 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 785,915 | 700,653 | -85,262 | 0.18 | 0.30 | +0.12 | sell |
| University of Wisconsin Foundation | 517,750 | 416,750 | -101,000 | 5.55 | 6.85 | +1.31 | sell |
| ORBIMED ADVISORS LLC | 2,314,184 | 2,202,184 | -112,000 | 0.70 | 0.88 | +0.18 | sell |
| WASATCH ADVISORS LP | 523,924 | 406,960 | -116,964 | 0.04 | 0.05 | +0.01 | sell |
| Saturn V Capital Management LP | 2,674,469 | 1,788,616 | -885,853 | 7.42 | 6.42 | -1.00 | sell |
| Logos Global Management LP | 2,400,000 | 1,250,000 | -1,150,000 | 3.00 | 1.63 | -1.37 | sell |
| Siren, L.L.C. | 4,729,174 | 3,502,941 | -1,226,233 | 2.34 | 2.04 | -0.30 | sell |
| BRAIDWELL LP | 2,730,481 | 1,478,329 | -1,252,152 | 1.02 | 0.92 | -0.10 | sell |
| Vestal Point Capital, LP | 2,775,000 | 120,000 | -2,655,000 | 1.59 | 0.09 | -1.51 | sell |