| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 808,153 | 3,377,000 | +2,568,847 | 0.33 | 1.58 | +1.25 | buy |
| Alyeska Investment Group, L.P. | 17,198 | 691,109 | +673,911 | 0.00 | 0.06 | +0.05 | buy |
| RTW INVESTMENTS, LP | 13,300,620 | 13,900,620 | +600,000 | 2.77 | 3.71 | +0.94 | buy |
| Candriam S.C.A. | 1,269,246 | 1,630,553 | +361,307 | 0.14 | 0.23 | +0.09 | buy |
| Atle Fund Management AB | 29,915 | 198,557 | +168,642 | 1.17 | 1.67 | +0.50 | buy |
| HighVista Strategies LLC | 104,193 | 260,070 | +155,877 | 0.60 | 1.85 | +1.25 | buy |
| Rock Springs Capital Management LP | 386,915 | 456,551 | +69,636 | 0.48 | 0.70 | +0.22 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,146,813 | 4,190,611 | +43,798 | 1.02 | 1.37 | +0.34 | buy |
| CONGRESS ASSET MANAGEMENT CO | 341,361 | 380,746 | +39,385 | 0.05 | 0.07 | +0.02 | buy |
| Harvest Investment Services, LLC | 25,376 | 59,067 | +33,691 | 0.10 | 0.29 | +0.19 | buy |
| China Universal Asset Management Co., Ltd. | 23,900 | 29,021 | +5,121 | 0.04 | 0.05 | +0.02 | buy |
| ANTIPODES PARTNERS Ltd | 1,622 | 1,037 | -585 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 167,998 | 134,014 | -33,984 | 0.41 | 0.37 | -0.03 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 441,831 | 390,949 | -50,882 | 6.52 | 8.52 | +2.00 | sell |
| PFM Health Sciences, LP | 406,245 | 326,047 | -80,198 | 0.77 | 0.87 | +0.10 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 343,563 | 254,250 | -89,313 | 1.14 | 1.04 | -0.10 | sell |
| Cormorant Asset Management, LP | 1,425,000 | 1,300,000 | -125,000 | 1.50 | 2.08 | +0.59 | sell |
| Nantahala Capital Management, LLC | 1,250,452 | 500,659 | -749,793 | 0.96 | 0.52 | -0.44 | sell |
| Vivo Capital, LLC | 2,154,780 | 1,379,769 | -775,011 | 3.75 | 3.94 | +0.19 | sell |
| Bellevue Group AG | 2,400,000 | 694,182 | -1,705,818 | 1.19 | 0.46 | -0.74 | sell |