| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TRV GP IV, LLC | 19,363,975 | 19,201,475 | -162,500 | 77.88 | 73.88 | -4.00 | sell |
| EcoR1 Capital, LLC | 13,330,736 | 13,330,736 | 0 | 3.43 | 2.69 | -0.74 | hold |
| FMR LLC | 9,787,350 | 9,491,655 | -295,695 | 0.01 | 0.01 | -0.00 | sell |
| Southpoint Capital Advisors LP | 5,276,699 | 5,276,699 | 0 | 1.12 | 0.83 | -0.29 | hold |
| T. Rowe Price Investment Management, Inc. | 286,694 | 4,321,551 | +4,034,857 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 2,979,212 | 3,080,885 | +101,673 | 0.00 | 0.00 | -0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,892,663 | 2,892,663 | 0 | 2.74 | 1.85 | -0.90 | hold |
| STATE STREET CORP | 978,938 | 2,866,098 | +1,887,160 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,400,000 | 2,294,206 | -1,105,794 | 0.07 | 0.03 | -0.04 | sell |
| Artal Group S.A. | 0 | 2,194,841 | +2,194,841 | 0.00 | 0.45 | +0.45 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,540,000 | 1,540,000 | 0 | 0.28 | 0.21 | -0.07 | hold |
| Soleus Capital Management, L.P. | 847,145 | 1,350,145 | +503,000 | 0.93 | 0.94 | +0.01 | buy |
| Casdin Capital, LLC | 1,188,349 | 1,188,349 | 0 | 1.16 | 0.70 | -0.46 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,097,102 | 1,133,535 | +36,433 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 750,000 | 750,000 | 0 | 0.08 | 0.07 | -0.01 | hold |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.08 | 0.06 | -0.01 | hold |
| BESSEMER GROUP INC | 708,384 | 708,384 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Samsara BioCapital, LLC | 630,000 | 630,000 | 0 | 0.97 | 0.77 | -0.20 | hold |
| GOLDMAN SACHS GROUP INC | 449,215 | 613,702 | +164,487 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 495,213 | 506,382 | +11,169 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 201,815 | 466,118 | +264,303 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 412,404 | 401,129 | -11,275 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 369,066 | 379,477 | +10,411 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 236,392 | 307,235 | +70,843 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 59,914 | 235,656 | +175,742 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 220,019 | +220,019 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 180,598 | 196,384 | +15,786 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 8,163 | 191,433 | +183,270 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 201,899 | 183,486 | -18,413 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 143,407 | 179,519 | +36,112 | 0.00 | 0.00 | -0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 168,400 | +168,400 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 0 | 158,226 | +158,226 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 300,274 | 150,274 | -150,000 | 0.59 | 0.19 | -0.40 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 170,228 | 140,995 | -29,233 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 140,968 | 126,250 | -14,718 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 49,803 | 122,697 | +72,894 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 109,269 | +109,269 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 59,796 | 108,043 | +48,247 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 100,691 | 100,691 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 114,357 | 86,161 | -28,196 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,359 | 81,132 | +40,773 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 80,200 | 80,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 70,409 | 78,477 | +8,068 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 70,390 | 71,437 | +1,047 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 156 | 67,115 | +66,959 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 121,000 | 65,600 | -55,400 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 99,808 | 65,198 | -34,610 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 0 | 59,778 | +59,778 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 72,640 | 58,180 | -14,460 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 86,224 | 52,628 | -33,596 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 22,176 | 50,974 | +28,798 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 52,105 | 50,894 | -1,211 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 36,640 | 47,960 | +11,320 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,416 | 42,892 | +16,476 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,548 | 41,149 | -2,399 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 36,407 | 36,407 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PROFUND ADVISORS LLC | 0 | 34,297 | +34,297 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 34,262 | +34,262 | 0.00 | 0.01 | +0.01 | buy |
| Integrity Wealth Solutions LLC | 33,199 | 33,199 | 0 | 0.23 | 0.17 | -0.06 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 16,474 | 31,346 | +14,872 | 0.00 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 26,226 | 30,429 | +4,203 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 21,836 | 28,964 | +7,128 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 467,253 | 28,054 | -439,199 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,080 | 27,293 | +9,213 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 0 | 26,961 | +26,961 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 25,780 | 25,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clear Harbor Asset Management, LLC | 21,200 | 25,495 | +4,295 | 0.02 | 0.02 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 24,405 | +24,405 | 0.00 | 0.01 | +0.01 | buy |
| FISHMAN JAY A LTD/MI | 14,000 | 24,000 | +10,000 | 0.02 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 24,083 | 22,529 | -1,554 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,096 | 22,074 | -22 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 22,190 | 22,001 | -189 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 21,494 | +21,494 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 55,814 | 21,338 | -34,476 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 24,629 | 20,343 | -4,286 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,793 | 19,569 | +7,776 | 0.02 | 0.02 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 294,558 | 19,090 | -275,468 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 18,200 | 15,900 | -2,300 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 13,788 | 15,813 | +2,025 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 17,766 | 15,779 | -1,987 | 0.06 | 0.05 | -0.01 | sell |
| ProShare Advisors LLC | 13,906 | 15,169 | +1,263 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 18,449 | 14,728 | -3,721 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 14,434 | +14,434 | 0.00 | 0.02 | +0.02 | buy |
| LMR Partners LLP | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,902 | 13,877 | -25 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 22,162 | 13,172 | -8,990 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,345 | 12,771 | +1,426 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 12,296 | +12,296 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,200 | 12,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 0 | 11,961 | +11,961 | 0.00 | 0.02 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 11,908 | 11,895 | -13 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 0 | 11,467 | +11,467 | 0.00 | 0.02 | +0.02 | buy |
| Arizona State Retirement System | 11,377 | 11,212 | -165 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 10,752 | 10,897 | +145 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 10,398 | +10,398 | 0.00 | 0.01 | +0.01 | buy |
| Paloma Partners Management Co | 0 | 10,040 | +10,040 | 0.00 | 0.01 | +0.01 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 10,040 | +10,040 | 0.00 | 0.01 | +0.01 | buy |