| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MARSHALL WACE, LLP | 0 | 1,842,163 | +1,842,163 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 249,646 | 1,470,932 | +1,221,286 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,000,000 | 4,610,930 | +610,930 | 0.07 | 0.03 | -0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 495,106 | 973,309 | +478,203 | 0.00 | 0.00 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 1,732,152 | 2,121,652 | +389,500 | 1.23 | 0.94 | -0.30 | buy |
| JANE STREET GROUP, LLC | 95,229 | 352,897 | +257,668 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 517,426 | 737,955 | +220,529 | 0.01 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 2,804,410 | 2,987,983 | +183,573 | 0.61 | 0.34 | -0.27 | buy |
| GSA CAPITAL PARTNERS LLP | 86,445 | 241,729 | +155,284 | 0.02 | 0.03 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 21,500 | 174,500 | +153,000 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 142,108 | +142,108 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 394,397 | 506,188 | +111,791 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 77,937 | 168,145 | +90,208 | 0.02 | 0.01 | -0.01 | buy |
| Graham Capital Management, L.P. | 34,804 | 116,498 | +81,694 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 272,233 | 351,489 | +79,256 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 11,198 | 82,657 | +71,459 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 26,200 | 97,000 | +70,800 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 154,947 | 224,077 | +69,130 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 70,452 | 129,110 | +58,658 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 57,599 | +57,599 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 57,086 | +57,086 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,067 | 51,183 | +49,116 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 17,426 | 65,327 | +47,901 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 41,346 | +41,346 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 29,534 | 70,517 | +40,983 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,693 | 47,529 | +40,836 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 513,429 | 548,014 | +34,585 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 36,653 | 53,788 | +17,135 | 0.00 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 10,764 | 25,801 | +15,037 | 0.01 | 0.01 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 27,919 | 40,157 | +12,238 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 10,632 | +10,632 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 10,586 | +10,586 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 103,020 | 113,233 | +10,213 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 44,996 | 52,902 | +7,906 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 7,583 | +7,583 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 687 | 6,566 | +5,879 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 25,495 | 30,299 | +4,804 | 0.01 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 3,630 | +3,630 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,837 | 10,742 | +1,905 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 71 | 1,738 | +1,667 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 1,572 | +1,572 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,998 | 22,252 | +1,254 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,411 | 28,638 | +1,227 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 65,740 | 66,806 | +1,066 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 969 | +969 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,809 | 6,566 | +757 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 568 | +568 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,255 | 2,665 | +410 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,580 | 3,733 | +153 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,296 | 19,438 | +142 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 11 | 41 | +30 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 10 | 34 | +24 | 0.00 | 0.00 | 0.00 | buy |
| True Wealth Design, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 708,384 | 708,384 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 550,000 | 550,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| Ameritas Investment Partners, Inc. | 4,378 | 4,378 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 655,158 | 655,158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 64,940 | 64,940 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 355 | 355 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.03 | 0.02 | -0.01 | hold |
| EcoR1 Capital, LLC | 10,630,736 | 10,630,736 | 0 | 1.31 | 0.86 | -0.45 | hold |
| TRV GP IV, LLC | 16,859,075 | 16,859,075 | 0 | 64.97 | 24.88 | -40.09 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,712,008 | 2,712,008 | 0 | 0.99 | 0.55 | -0.44 | hold |
| Samsara BioCapital, LLC | 630,000 | 630,000 | 0 | 0.27 | 0.15 | -0.11 | hold |
| TFC Financial Management, Inc. | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TCG Crossover Management, LLC | 10,736,000 | 10,736,000 | 0 | 3.24 | 2.01 | -1.24 | hold |
| Simplicity Wealth,LLC | 26,961 | 26,961 | 0 | 0.02 | 0.00 | -0.01 | hold |
| Fortitude Family Office, LLC | 1,198 | 1,198 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TRV GP VI, LLC | 194,174 | 194,174 | 0 | 0.51 | 0.63 | +0.12 | hold |
| Boxer Capital Management, LLC | 10,380,999 | 10,380,999 | 0 | 2.73 | 4.28 | +1.55 | hold |
| Police & Firemen's Retirement System of New Jersey | 9,218 | 9,218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,576 | 6,576 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GILEAD SCIENCES, INC. | 4,854,443 | 4,854,443 | 0 | 0.97 | 0.56 | -0.40 | hold |
| AMALGAMATED BANK | 1,618 | 1,618 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,780 | 12,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 6,997 | 6,800 | -197 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 346 | 0 | -346 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 23,719 | 23,373 | -346 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 748 | 321 | -427 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 474 | 0 | -474 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 40,000 | 39,500 | -500 | 0.00 | 0.00 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 227,989 | 227,361 | -628 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 15,149 | 14,398 | -751 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 22,777 | 21,685 | -1,092 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 126,553 | 124,865 | -1,688 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,386,449 | 1,383,437 | -3,012 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 3,140 | 0 | -3,140 | 0.01 | 0.00 | -0.01 | sell |
| ProShare Advisors LLC | 18,524 | 15,205 | -3,319 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 21,963 | 17,029 | -4,934 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 46,992 | 41,823 | -5,169 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 6,300 | 0 | -6,300 | 0.00 | 0.00 | -0.00 | sell |
| Stonebrook Private Inc. | 10,992 | 0 | -10,992 | 0.01 | 0.00 | -0.01 | sell |
| JANUS HENDERSON GROUP PLC | 11,631 | 0 | -11,631 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 12,307 | 0 | -12,307 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 12,843 | 0 | -12,843 | 0.00 | 0.00 | -0.00 | sell |