| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 1,491,228 | 13,300,620 | +11,809,392 | 0.13 | 2.77 | +2.64 | buy |
| FMR LLC | 2,867,548 | 9,905,919 | +7,038,371 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 0 | 4,009,679 | +4,009,679 | 0.00 | 1.71 | +1.71 | buy |
| Holocene Advisors, LP | 0 | 3,932,603 | +3,932,603 | 0.00 | 0.20 | +0.20 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 10,607,924 | 12,809,485 | +2,201,561 | 0.14 | 0.41 | +0.27 | buy |
| Cormorant Asset Management, LP | 0 | 1,425,000 | +1,425,000 | 0.00 | 1.50 | +1.50 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,906,946 | 4,146,813 | +1,239,867 | 0.33 | 1.02 | +0.69 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,434 | 889,400 | +830,966 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 708,812 | 1,269,246 | +560,434 | 0.03 | 0.14 | +0.11 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 506,158 | +506,158 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 10,000 | 450,000 | +440,000 | 0.00 | 0.38 | +0.38 | buy |
| PFM Health Sciences, LP | 0 | 406,245 | +406,245 | 0.00 | 0.89 | +0.89 | buy |
| Invesco Ltd. | 177,610 | 580,453 | +402,843 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 395,081 | +395,081 | 0.00 | 0.41 | +0.41 | buy |
| Deep Track Capital, LP | 2,454,562 | 2,750,000 | +295,438 | 0.50 | 1.19 | +0.69 | buy |
| PERCEPTIVE ADVISORS LLC | 513,035 | 808,153 | +295,118 | 0.08 | 0.33 | +0.25 | buy |
| Parkman Healthcare Partners LLC | 0 | 266,127 | +266,127 | 0.00 | 0.58 | +0.58 | buy |
| Integral Health Asset Management, LLC | 200,000 | 450,000 | +250,000 | 0.09 | 0.50 | +0.41 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 129,476 | 355,229 | +225,753 | 0.00 | 0.02 | +0.01 | buy |
| Cinctive Capital Management LP | 0 | 222,111 | +222,111 | 0.00 | 0.31 | +0.31 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 207,504 | +207,504 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 8,540,797 | 8,748,045 | +207,248 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 200,919 | +200,919 | 0.00 | 0.81 | +0.81 | buy |
| Informed Momentum Co LLC | 0 | 167,998 | +167,998 | 0.00 | 0.41 | +0.41 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 282,732 | 441,831 | +159,099 | 1.70 | 6.57 | +4.87 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 150,070 | +150,070 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 145,640 | +145,640 | 0.00 | 0.05 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 4,942,414 | 5,076,392 | +133,978 | 0.01 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,811 | 175,469 | +127,658 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,553,656 | 2,675,777 | +122,121 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 120,689 | +120,689 | 0.00 | 0.02 | +0.02 | buy |
| CONGRESS ASSET MANAGEMENT CO | 234,628 | 341,361 | +106,733 | 0.01 | 0.05 | +0.04 | buy |
| HighVista Strategies LLC | 0 | 104,193 | +104,193 | 0.00 | 0.60 | +0.60 | buy |
| TD ASSET MANAGEMENT INC | 0 | 102,600 | +102,600 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,342 | 108,218 | +75,876 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 300,441 | 360,818 | +60,377 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 803,199 | 862,940 | +59,741 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,421,794 | 1,477,488 | +55,694 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 233,857 | 289,180 | +55,323 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 52,764 | +52,764 | 0.00 | 0.08 | +0.08 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,216 | 86,350 | +51,134 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,206 | 52,801 | +42,595 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 887 | 36,340 | +35,453 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 41,453 | 75,717 | +34,264 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 32,047 | +32,047 | 0.00 | 0.01 | +0.01 | buy |
| Atle Fund Management AB | 0 | 29,915 | +29,915 | 0.00 | 1.17 | +1.17 | buy |
| TWO SIGMA INVESTMENTS, LP | 144,432 | 173,132 | +28,700 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 151,880 | 179,423 | +27,543 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 25,376 | +25,376 | 0.00 | 0.10 | +0.10 | buy |
| AQR CAPITAL MANAGEMENT LLC | 82,233 | 107,286 | +25,053 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 23,116 | +23,116 | 0.00 | 0.19 | +0.19 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,563 | 30,625 | +21,062 | 0.00 | 0.00 | +0.00 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 20,463 | +20,463 | 0.00 | 0.62 | +0.62 | buy |
| Jain Global LLC | 0 | 20,370 | +20,370 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 19,160 | +19,160 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 0 | 19,137 | +19,137 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 17,198 | +17,198 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,337 | 45,348 | +16,011 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 74,203 | 89,975 | +15,772 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 15,210 | +15,210 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 13,194 | +13,194 | 0.00 | 0.01 | +0.01 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 12,557 | +12,557 | 0.00 | 0.02 | +0.02 | buy |
| SummitTX Capital, L.P. | 0 | 12,535 | +12,535 | 0.00 | 0.01 | +0.01 | buy |
| Bleakley Financial Group, LLC | 0 | 12,381 | +12,381 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 106,490 | 117,620 | +11,130 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 41,907 | 52,907 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 56,835 | 67,326 | +10,491 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 10,238 | +10,238 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 10,160 | +10,160 | 0.00 | 0.00 | +0.00 | buy |
| Abacus Wealth Partners, LLC | 0 | 9,561 | +9,561 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,576 | 33,476 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,780 | 21,051 | +8,271 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 7,408 | +7,408 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,467 | 10,647 | +6,180 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 6,120 | +6,120 | 0.00 | 0.02 | +0.02 | buy |
| Entropy Technologies, LP | 14,792 | 20,656 | +5,864 | 0.01 | 0.02 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,740 | 7,240 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 173,936 | 178,915 | +4,979 | 0.00 | 0.01 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 20,402 | 23,517 | +3,115 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 9,794 | 12,840 | +3,046 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 487,076 | 489,348 | +2,272 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 22,006 | 24,257 | +2,251 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 28,294 | 30,350 | +2,056 | 0.00 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,946 | 23,900 | +1,954 | 0.01 | 0.04 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,056 | +1,056 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 0 | 1,047 | +1,047 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 59,692 | 60,694 | +1,002 | 0.00 | 0.01 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 817 | +817 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 28,452 | 29,163 | +711 | 0.07 | 0.17 | +0.10 | buy |
| Caitong International Asset Management Co., Ltd | 320 | 1,005 | +685 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 45 | 563 | +518 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 487 | +487 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 6,544 | 7,025 | +481 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 8,633 | 9,089 | +456 | 0.00 | 0.01 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 25,646 | 26,026 | +380 | 0.01 | 0.02 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,646 | 3,011 | +365 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 1,300 | 1,550 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 34 | 250 | +216 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 4,832 | 5,039 | +207 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |