| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 466,118 | 1,231,757 | +765,639 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 447,107 | +447,107 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 4,321,551 | 4,755,979 | +434,428 | 0.02 | 0.03 | +0.00 | buy |
| Woodline Partners LP | 0 | 348,091 | +348,091 | 0.00 | 0.03 | +0.03 | buy |
| Artal Group S.A. | 2,194,841 | 2,519,841 | +325,000 | 0.45 | 0.56 | +0.11 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 277,009 | +277,009 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 3,080,885 | 3,294,572 | +213,687 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 211,170 | +211,170 | 0.00 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 115,571 | +115,571 | 0.00 | 1.25 | +1.25 | buy |
| DIMENSIONAL FUND ADVISORS LP | 235,656 | 335,913 | +100,257 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,133,535 | 1,225,552 | +92,017 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,200 | 78,722 | +66,522 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 179,519 | 243,369 | +63,850 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 81,132 | 138,247 | +57,115 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 100,691 | 154,947 | +54,256 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 49,753 | +49,753 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 379,477 | 410,697 | +31,220 | 0.00 | 0.00 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 28,380 | +28,380 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 34,262 | 62,417 | +28,155 | 0.01 | 0.01 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 47,960 | 64,940 | +16,980 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 52,628 | 68,890 | +16,262 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 26,961 | 43,041 | +16,080 | 0.01 | 0.01 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 16,080 | +16,080 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 126,250 | 141,623 | +15,373 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 14,658 | +14,658 | 0.00 | 0.06 | +0.06 | buy |
| Tower Research Capital LLC (TRC) | 1,439 | 15,682 | +14,243 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 12,780 | +12,780 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 11,500 | +11,500 | 0.00 | 0.04 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 10,497 | +10,497 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 140,995 | 149,777 | +8,782 | 0.00 | 0.00 | +0.00 | buy |
| Castleview Partners, LLC | 0 | 6,944 | +6,944 | 0.00 | 0.03 | +0.03 | buy |
| Point72 (DIFC) Ltd | 0 | 6,281 | +6,281 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 80,200 | 83,900 | +3,700 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 22,529 | 25,448 | +2,919 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,780 | 28,264 | +2,484 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,771 | 15,234 | +2,463 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 8,502 | 10,790 | +2,288 | 0.04 | 0.05 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,293 | 29,511 | +2,218 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,343 | 22,500 | +2,157 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,728 | 16,449 | +1,721 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 36,407 | 38,081 | +1,674 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 613,702 | 614,918 | +1,216 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,149 | 42,144 | +995 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,212 | 11,952 | +740 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 28,054 | 28,433 | +379 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 78,477 | 78,696 | +219 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 490 | 629 | +139 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 464 | 567 | +103 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 52 | 107 | +55 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 51 | 70 | +19 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 2 | 6 | +4 | 0.00 | 0.00 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,540,000 | 1,540,000 | 0 | 0.21 | 0.22 | +0.01 | hold |
| BESSEMER GROUP INC | 708,384 | 708,384 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,378 | 4,378 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 59,778 | 59,778 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,294,206 | 2,294,206 | 0 | 0.03 | 0.04 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 750,000 | 750,000 | 0 | 0.07 | 0.08 | +0.01 | hold |
| Southpoint Capital Advisors LP | 5,276,699 | 5,276,699 | 0 | 0.83 | 1.13 | +0.30 | hold |
| Janney Montgomery Scott LLC | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 355 | 355 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.06 | 0.07 | +0.01 | hold |
| Clear Harbor Asset Management, LLC | 25,495 | 25,495 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Casdin Capital, LLC | 1,188,349 | 1,188,349 | 0 | 0.70 | 0.78 | +0.08 | hold |
| LMR Partners LLP | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 13,330,736 | 13,330,736 | 0 | 2.69 | 3.50 | +0.81 | hold |
| TRV GP IV, LLC | 19,201,475 | 19,201,475 | 0 | 73.88 | 81.48 | +7.60 | hold |
| Russell Investments Group, Ltd. | 31 | 31 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,892,663 | 2,892,663 | 0 | 1.85 | 2.72 | +0.88 | hold |
| Samsara BioCapital, LLC | 630,000 | 630,000 | 0 | 0.77 | 1.13 | +0.36 | hold |
| Affinity Asset Advisors, LLC | 150,274 | 150,274 | 0 | 0.19 | 0.20 | +0.01 | hold |
| Alaethes Wealth, LLC | 10,000 | 10,000 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Covestor Ltd | 10 | 10 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Farther Finance Advisors, LLC | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,618 | 1,618 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avior Wealth Management, LLC | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,877 | 13,826 | -51 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 11,895 | 11,631 | -264 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 15,813 | 15,274 | -539 | 0.00 | 0.00 | +0.00 | sell |
| Pacer Advisors, Inc. | 1,022 | 415 | -607 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 2,349 | 98 | -2,251 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,484 | 0 | -2,484 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 15,169 | 12,574 | -2,595 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 71,437 | 67,340 | -4,097 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 19,090 | 14,911 | -4,179 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,434 | 10,041 | -4,393 | 0.02 | 0.01 | -0.01 | sell |
| FISHMAN JAY A LTD/MI | 24,000 | 19,000 | -5,000 | 0.02 | 0.02 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,074 | 15,376 | -6,698 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 158,226 | 151,315 | -6,911 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 19,569 | 12,552 | -7,017 | 0.02 | 0.02 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 31,346 | 23,909 | -7,437 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 401,129 | 391,576 | -9,553 | 0.00 | 0.00 | +0.00 | sell |
| Paloma Partners Management Co | 10,040 | 0 | -10,040 | 0.01 | 0.00 | -0.01 | sell |
| MIRABELLA FINANCIAL SERVICES LLP | 10,040 | 0 | -10,040 | 0.01 | 0.00 | -0.01 | sell |
| E Fund Management Co., Ltd. | 10,398 | 0 | -10,398 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 10,500 | 0 | -10,500 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 10,897 | 0 | -10,897 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 11,961 | 703 | -11,258 | 0.02 | 0.00 | -0.02 | sell |