| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TRV GP IV, LLC | 16,859,075 | 16,859,075 | 0 | 24.88 | 52.85 | +27.98 | hold |
| TCG Crossover Management, LLC | 10,736,000 | 10,736,000 | 0 | 2.01 | 6.28 | +4.27 | hold |
| EcoR1 Capital, LLC | 10,630,736 | 10,630,736 | 0 | 0.86 | 3.23 | +2.36 | hold |
| Boxer Capital Management, LLC | 10,380,999 | 9,771,485 | -609,514 | 4.28 | 25.18 | +20.91 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 4,610,930 | 9,157,000 | +4,546,070 | 0.03 | 0.21 | +0.18 | buy |
| Woodline Partners LP | 506,188 | 6,029,906 | +5,523,718 | 0.00 | 0.16 | +0.16 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 5,905,349 | +5,905,349 | 0.00 | 0.05 | +0.05 | buy |
| Nextech Invest, Ltd. | 5,533,980 | 5,533,980 | 0 | 1.76 | 5.36 | +3.60 | hold |
| BlackRock, Inc. | 4,032,012 | 5,463,266 | +1,431,254 | 0.00 | 0.00 | +0.00 | buy |
| GILEAD SCIENCES, INC. | 4,854,443 | 4,854,443 | 0 | 0.56 | 1.94 | +1.38 | hold |
| VANGUARD GROUP INC | 3,875,545 | 4,026,800 | +151,255 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 2,987,983 | 3,439,594 | +451,611 | 0.34 | 1.25 | +0.91 | buy |
| Siren, L.L.C. | 2,565,342 | 3,364,814 | +799,472 | 0.20 | 0.89 | +0.69 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,219,571 | 3,247,463 | +27,892 | 0.01 | 0.04 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 3,312,449 | 3,169,226 | -143,223 | 0.00 | 0.01 | +0.01 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,712,008 | 2,712,008 | 0 | 0.55 | 1.74 | +1.19 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.17 | +0.17 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,470,932 | 1,772,304 | +301,372 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,383,437 | 1,768,913 | +385,476 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,842,163 | 1,742,691 | -99,472 | 0.00 | 0.01 | +0.01 | sell |
| Commodore Capital LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.54 | +0.54 | buy |
| STATE STREET CORP | 1,144,443 | 1,382,686 | +238,243 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 2,121,652 | 814,416 | -1,307,236 | 0.94 | 1.35 | +0.41 | sell |
| Soleus Capital Management, L.P. | 0 | 730,000 | +730,000 | 0.00 | 0.26 | +0.26 | buy |
| Candriam S.C.A. | 0 | 708,812 | +708,812 | 0.00 | 0.02 | +0.02 | buy |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.02 | 0.07 | +0.05 | hold |
| BESSEMER GROUP INC | 708,384 | 708,384 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 548,014 | 601,447 | +53,433 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 449,382 | 600,508 | +151,126 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.31 | +0.31 | buy |
| MORGAN STANLEY | 0 | 534,621 | +534,621 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 605,290 | 525,098 | -80,192 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 202,183 | 442,963 | +240,780 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 418,517 | +418,517 | 0.00 | 0.09 | +0.09 | buy |
| UBS Group AG | 0 | 277,102 | +277,102 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 252,273 | +252,273 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 242,447 | +242,447 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 227,361 | 227,194 | -167 | 0.00 | 0.01 | +0.01 | sell |
| Fisher Asset Management, LLC | 224,077 | 224,077 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 737,955 | 218,779 | -519,176 | 0.00 | 0.00 | +0.00 | sell |
| Samsara BioCapital, LLC | 630,000 | 210,000 | -420,000 | 0.15 | 0.22 | +0.07 | sell |
| STEMPOINT CAPITAL LP | 0 | 208,800 | +208,800 | 0.00 | 0.34 | +0.34 | buy |
| TRV GP VI, LLC | 194,174 | 194,174 | 0 | 0.63 | 1.55 | +0.91 | hold |
| FRED ALGER MANAGEMENT, LLC | 0 | 191,337 | +191,337 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 113,233 | 187,997 | +74,764 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 232,766 | 159,837 | -72,929 | 0.01 | 0.02 | +0.02 | sell |
| BARCLAYS PLC | 63,032 | 138,650 | +75,618 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 124,865 | 125,207 | +342 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 125,000 | 125,000 | 0 | 0.00 | 0.02 | +0.01 | hold |
| RHUMBLINE ADVISERS | 66,806 | 112,273 | +45,467 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 172,433 | 108,179 | -64,254 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 64,940 | 106,010 | +41,070 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 70,517 | 95,293 | +24,776 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 973,309 | 81,953 | -891,356 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 142,108 | 78,946 | -63,162 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 0 | 66,675 | +66,675 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 174,500 | 65,500 | -109,000 | 0.00 | 0.00 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Polar Asset Management Partners Inc. | 0 | 56,100 | +56,100 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 168,145 | 55,806 | -112,339 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 55,065 | +55,065 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 53,788 | 52,661 | -1,127 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 49,901 | +49,901 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 49,217 | +49,217 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 47,726 | +47,726 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 40,157 | 45,675 | +5,518 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28,638 | 41,998 | +13,360 | 0.00 | 0.00 | +0.00 | buy |
| Allostery Investments LP | 0 | 40,000 | +40,000 | 0.00 | 2.61 | +2.61 | buy |
| Janney Montgomery Scott LLC | 39,500 | 39,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,252 | 38,401 | +16,149 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 30,299 | 30,299 | 0 | 0.00 | 0.01 | +0.01 | hold |
| CITIGROUP INC | 41,823 | 30,291 | -11,532 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,438 | 28,805 | +9,367 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 26,961 | 26,961 | 0 | 0.00 | 0.01 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 26 | 26,631 | +26,605 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 52,902 | 22,218 | -30,684 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 21,685 | 21,771 | +86 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,398 | 21,295 | +6,897 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 10,632 | 20,369 | +9,737 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,205 | 19,775 | +4,570 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 57,599 | 18,620 | -38,979 | 0.02 | 0.03 | +0.01 | sell |
| Police & Firemen's Retirement System of New Jersey | 9,218 | 17,647 | +8,429 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,780 | 12,780 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Savant Capital, LLC | 0 | 11,872 | +11,872 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 11,231 | +11,231 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 129,110 | 10,290 | -118,820 | 0.00 | 0.00 | -0.00 | sell |
| Northeast Financial Consultants Inc | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,566 | 9,473 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 47,529 | 8,609 | -38,920 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 4,378 | 7,830 | +3,452 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,345 | 6,985 | +1,640 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,576 | 6,576 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 6,800 | 6,189 | -611 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 10,742 | 5,578 | -5,164 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 1,738 | 4,905 | +3,167 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,457 | 4,785 | +1,328 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,733 | 4,187 | +454 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,665 | 2,665 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 49 | 2,071 | +2,022 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,618 | 1,618 | 0 | 0.00 | 0.00 | +0.00 | hold |