| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 13,300,620 | 13,900,620 | +600,000 | 2.77 | 3.71 | +0.94 | buy |
| BlackRock, Inc. | 8,748,045 | 12,438,444 | +3,690,399 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 9,905,919 | 12,333,339 | +2,427,420 | 0.01 | 0.02 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 9,097,411 | 12,277,000 | +3,179,589 | 1.13 | 2.25 | +1.12 | buy |
| Boxer Capital Management, LLC | 10,876,219 | 10,876,219 | 0 | 29.87 | 25.61 | -4.27 | hold |
| GOLDMAN SACHS GROUP INC | 5,076,392 | 9,980,620 | +4,904,228 | 0.01 | 0.03 | +0.02 | buy |
| TCG Crossover Management, LLC | 10,531,071 | 9,081,201 | -1,449,870 | 6.30 | 6.82 | +0.52 | sell |
| TRV GP IV, LLC | 6,374,574 | 6,374,574 | 0 | 49.96 | 47.37 | -2.59 | hold |
| Paradigm Biocapital Advisors LP | 4,009,679 | 6,357,523 | +2,347,844 | 1.71 | 3.72 | +2.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 889,400 | 6,348,827 | +5,459,427 | 0.00 | 0.02 | +0.02 | buy |
| Siren, L.L.C. | 5,657,105 | 6,179,364 | +522,259 | 3.28 | 3.92 | +0.64 | buy |
| STATE STREET CORP | 4,651,894 | 5,979,806 | +1,327,912 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 12,809,485 | 5,600,000 | -7,209,485 | 0.41 | 0.25 | -0.17 | sell |
| Deep Track Capital, LP | 2,750,000 | 4,200,000 | +1,450,000 | 1.19 | 1.93 | +0.75 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,146,813 | 4,190,611 | +43,798 | 1.02 | 1.37 | +0.34 | buy |
| Woodline Partners LP | 8,000,013 | 4,000,567 | -3,999,446 | 0.63 | 0.39 | -0.25 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,675,777 | 3,742,791 | +1,067,014 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 808,153 | 3,377,000 | +2,568,847 | 0.33 | 1.64 | +1.31 | buy |
| Logos Global Management LP | 3,000,000 | 2,850,000 | -150,000 | 3.23 | 3.84 | +0.60 | sell |
| Caligan Partners LP | 2,408,798 | 2,500,103 | +91,305 | 3.56 | 3.77 | +0.21 | buy |
| Holocene Advisors, LP | 3,932,603 | 2,410,939 | -1,521,664 | 0.20 | 0.17 | -0.03 | sell |
| Commodore Capital LP | 0 | 2,250,000 | +2,250,000 | 0.00 | 4.19 | +4.19 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,826,659 | 2,016,379 | -1,810,280 | 0.16 | 0.12 | -0.04 | sell |
| Jefferies Financial Group Inc. | 0 | 2,010,534 | +2,010,534 | 0.00 | 0.58 | +0.58 | buy |
| FRANKLIN RESOURCES INC | 1,296,283 | 1,887,211 | +590,928 | 0.01 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 1,269,246 | 1,630,553 | +361,307 | 0.14 | 0.23 | +0.09 | buy |
| Polar Capital Holdings Plc | 0 | 1,480,740 | +1,480,740 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 67,326 | 1,418,193 | +1,350,867 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 2,154,780 | 1,379,769 | -775,011 | 3.75 | 3.94 | +0.19 | sell |
| Cormorant Asset Management, LP | 1,425,000 | 1,300,000 | -125,000 | 1.50 | 2.08 | +0.58 | sell |
| NORTHERN TRUST CORP | 862,940 | 1,231,933 | +368,993 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 200,919 | 1,223,019 | +1,022,100 | 0.81 | 6.62 | +5.81 | buy |
| FEDERATED HERMES, INC. | 354 | 1,214,613 | +1,214,259 | 0.00 | 0.05 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 175,469 | 1,103,030 | +927,561 | 0.00 | 0.03 | +0.03 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,072,059 | +1,072,059 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 838,675 | 1,072,059 | +233,384 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 1,013,794 | +1,013,794 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 450,000 | 1,000,000 | +550,000 | 0.50 | 1.28 | +0.78 | buy |
| Nuveen, LLC | 360,818 | 890,170 | +529,352 | 0.00 | 0.01 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 0 | 766,473 | +766,473 | 0.00 | 0.40 | +0.40 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 748,300 | +748,300 | 0.00 | 0.03 | +0.03 | buy |
| Soleus Capital Management, L.P. | 450,000 | 709,000 | +259,000 | 0.38 | 0.76 | +0.38 | buy |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.39 | 0.92 | +0.53 | hold |
| Bellevue Group AG | 2,400,000 | 694,182 | -1,705,818 | 1.19 | 0.46 | -0.74 | sell |
| Alyeska Investment Group, L.P. | 17,198 | 691,109 | +673,911 | 0.00 | 0.06 | +0.05 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 355,229 | 636,070 | +280,841 | 0.02 | 0.04 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 327,144 | 600,834 | +273,690 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 582,262 | +582,262 | 0.00 | 0.02 | +0.02 | buy |
| Fisher Asset Management, LLC | 162,399 | 578,158 | +415,759 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 532,109 | +532,109 | 0.00 | 0.05 | +0.05 | buy |
| JANE STREET GROUP, LLC | 0 | 514,265 | +514,265 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,477,488 | 510,778 | -966,710 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 509,309 | +509,309 | 0.00 | 0.01 | +0.01 | buy |
| Nantahala Capital Management, LLC | 1,250,452 | 500,659 | -749,793 | 1.63 | 0.95 | -0.69 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 571,350 | 500,497 | -70,853 | 0.28 | 0.29 | +0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 425,644 | 496,036 | +70,392 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 489,348 | 488,300 | -1,048 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 580,453 | 462,721 | -117,732 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 386,915 | 456,551 | +69,636 | 0.48 | 0.70 | +0.22 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 455,605 | +455,605 | 0.00 | 3.33 | +3.33 | buy |
| Longaeva Partners L.P. | 0 | 414,902 | +414,902 | 0.00 | 0.37 | +0.37 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.17 | +0.17 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 441,831 | 390,949 | -50,882 | 6.57 | 8.52 | +1.94 | sell |
| Bank of New York Mellon Corp | 318,458 | 390,920 | +72,462 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 699,352 | 383,694 | -315,658 | 0.00 | 0.00 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 341,361 | 380,746 | +39,385 | 0.05 | 0.07 | +0.02 | buy |
| BESSEMER GROUP INC | 708,398 | 354,206 | -354,192 | 0.02 | 0.02 | -0.01 | sell |
| LMR Partners LLP | 0 | 347,106 | +347,106 | 0.00 | 0.08 | +0.08 | buy |
| Assenagon Asset Management S.A. | 0 | 345,156 | +345,156 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 333,333 | +333,333 | 0.00 | 0.05 | +0.05 | buy |
| PFM Health Sciences, LP | 406,245 | 326,047 | -80,198 | 0.89 | 0.88 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 506,158 | 306,345 | -199,813 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 533,937 | 298,339 | -235,598 | 0.02 | 0.01 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 289,180 | 297,106 | +7,926 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 287,900 | +287,900 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 12,840 | 279,611 | +266,771 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 207,504 | 278,511 | +71,007 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 145,640 | 271,570 | +125,930 | 0.05 | 0.10 | +0.05 | buy |
| HighVista Strategies LLC | 104,193 | 260,070 | +155,877 | 0.60 | 1.85 | +1.25 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 343,563 | 254,250 | -89,313 | 1.24 | 1.14 | -0.10 | sell |
| T. Rowe Price Investment Management, Inc. | 440,015 | 252,109 | -187,906 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 173,132 | 241,783 | +68,651 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 102,600 | 221,968 | +119,368 | 0.00 | 0.01 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 208,500 | +208,500 | 0.00 | 1.12 | +1.12 | buy |
| Atle Fund Management AB | 29,915 | 198,557 | +168,642 | 1.17 | 1.67 | +0.50 | buy |
| TRV GP VI, LLC | 194,174 | 194,174 | 0 | 3.00 | 2.61 | -0.38 | hold |
| Walleye Capital LLC | 0 | 192,270 | +192,270 | 0.00 | 0.03 | +0.03 | buy |
| Swiss National Bank | 87,800 | 187,400 | +99,600 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 108,218 | 181,212 | +72,994 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 179,423 | 181,059 | +1,636 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 52,801 | 176,748 | +123,947 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 126,603 | 175,133 | +48,530 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 174,909 | +174,909 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 170,301 | +170,301 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 117,620 | 160,010 | +42,390 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,633 | 152,007 | +132,374 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.09 | +0.09 | buy |
| Burkehill Global Management, LP | 0 | 150,000 | +150,000 | 0.00 | 0.17 | +0.17 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.19 | +0.19 | buy |
| WELLS FARGO & COMPANY/MN | 41,972 | 144,991 | +103,019 | 0.00 | 0.00 | +0.00 | buy |