| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 277,009 | 2,687,196 | +2,410,187 | 0.01 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 1,231,757 | 2,694,125 | +1,462,368 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 1,828,259 | 2,318,208 | +489,949 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 115,571 | 599,048 | +483,477 | 1.25 | 4.12 | +2.87 | buy |
| VANGUARD GROUP INC | 3,294,572 | 3,645,303 | +350,731 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 49,753 | 384,500 | +334,747 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 151,315 | 440,831 | +289,516 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 4,755,979 | 5,023,146 | +267,167 | 0.03 | 0.02 | -0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.18 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,225,552 | 1,368,262 | +142,710 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 142,576 | +142,576 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 243,369 | 341,977 | +98,608 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 81,900 | 175,369 | +93,469 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 391,576 | 479,250 | +87,674 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410,697 | 487,237 | +76,540 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 73,122 | +73,122 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 63,296 | +63,296 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 70,811 | 126,281 | +55,470 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 45,272 | +45,272 | 0.00 | 0.03 | +0.03 | buy |
| XTX Topco Ltd | 10,041 | 44,191 | +34,150 | 0.01 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 32,020 | +32,020 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 30,910 | +30,910 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 72,889 | 102,955 | +30,066 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 335,913 | 360,689 | +24,776 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 21,185 | +21,185 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 59,778 | 79,978 | +20,200 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 19,644 | +19,644 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 78,696 | 98,286 | +19,590 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 22,065 | 38,676 | +16,611 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 10,901 | +10,901 | 0.00 | 0.01 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 10,713 | +10,713 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 703 | 10,885 | +10,182 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 12,552 | 20,607 | +8,055 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,500 | 29,525 | +7,025 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 98 | 7,087 | +6,989 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 13,893 | 20,473 | +6,580 | 0.00 | 0.01 | +0.00 | buy |
| EntryPoint Capital, LLC | 14,658 | 19,839 | +5,181 | 0.06 | 0.09 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,522 | 30,297 | +4,775 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,574 | 15,346 | +2,772 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 51,559 | 52,840 | +1,281 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,234 | 16,185 | +951 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,190 | 3,875 | +685 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 28,433 | 28,950 | +517 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 70 | 508 | +438 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,952 | 12,306 | +354 | 0.00 | 0.00 | -0.00 | buy |
| TFC Financial Management, Inc. | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 287 | +287 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 10,790 | 10,984 | +194 | 0.05 | 0.04 | -0.01 | buy |
| ROTHSCHILD INVESTMENT LLC | 30 | 95 | +65 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 31 | 69 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 6 | 10 | +4 | 0.00 | 0.00 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,540,000 | 1,540,000 | 0 | 0.22 | 0.18 | -0.04 | hold |
| BESSEMER GROUP INC | 708,384 | 708,384 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,378 | 4,378 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 64,940 | 64,940 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,294,206 | 2,294,206 | 0 | 0.04 | 0.03 | -0.01 | hold |
| BAKER BROS. ADVISORS LP | 750,000 | 750,000 | 0 | 0.08 | 0.06 | -0.02 | hold |
| JANUS HENDERSON GROUP PLC | 11,631 | 11,631 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Janney Montgomery Scott LLC | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,826 | 13,826 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 355 | 355 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Clear Harbor Asset Management, LLC | 25,495 | 25,495 | 0 | 0.02 | 0.02 | -0.00 | hold |
| MetLife Investment Management, LLC | 28,264 | 28,264 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Casdin Capital, LLC | 1,188,349 | 1,188,349 | 0 | 0.78 | 0.61 | -0.17 | hold |
| Swiss National Bank | 83,900 | 83,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 13,330,736 | 13,330,736 | 0 | 3.50 | 3.52 | +0.02 | hold |
| Castleview Partners, LLC | 6,944 | 6,944 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Samsara BioCapital, LLC | 630,000 | 630,000 | 0 | 1.13 | 0.93 | -0.20 | hold |
| Fortitude Family Office, LLC | 629 | 629 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fisher Asset Management, LLC | 154,947 | 154,947 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,618 | 1,618 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,780 | 12,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 10 | 9 | -1 | 0.00 | 0.00 | 0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 107 | 98 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 38,081 | 37,961 | -120 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 16,449 | 16,311 | -138 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 25,666 | 25,509 | -157 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 567 | 265 | -302 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 415 | 0 | -415 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 11,500 | 11,000 | -500 | 0.04 | 0.03 | -0.02 | sell |
| WELLS FARGO & COMPANY/MN | 15,274 | 14,693 | -581 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 15,682 | 14,765 | -917 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,144 | 40,767 | -1,377 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 1,400 | 0 | -1,400 | 0.00 | 0.00 | -0.00 | sell |
| Bleakley Financial Group, LLC | 16,080 | 14,427 | -1,653 | 0.00 | 0.00 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 211,170 | 209,070 | -2,100 | 0.01 | 0.01 | -0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 28,380 | 25,934 | -2,446 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 78,722 | 75,302 | -3,420 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 67,340 | 63,845 | -3,495 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 6,281 | 0 | -6,281 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 20,651 | 14,206 | -6,445 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 23,909 | 17,426 | -6,483 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 149,777 | 143,207 | -6,570 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 138,247 | 131,508 | -6,739 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,376 | 6,576 | -8,800 | 0.00 | 0.00 | -0.00 | sell |