| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TRV GP IV, LLC | 16,859,075 | 13,863,975 | -2,995,100 | 52.85 | 42.51 | -10.34 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 9,157,000 | 10,757,000 | +1,600,000 | 0.21 | 0.51 | +0.30 | buy |
| EcoR1 Capital, LLC | 10,630,736 | 10,630,736 | 0 | 3.23 | 4.29 | +1.06 | hold |
| Boxer Capital Management, LLC | 9,771,485 | 9,771,485 | 0 | 25.18 | 26.16 | +0.98 | hold |
| TCG Crossover Management, LLC | 10,736,000 | 8,536,196 | -2,199,804 | 6.28 | 3.53 | -2.75 | sell |
| Woodline Partners LP | 6,029,906 | 6,029,928 | +22 | 0.16 | 0.24 | +0.08 | buy |
| Siren, L.L.C. | 3,364,814 | 5,883,188 | +2,518,374 | 0.89 | 1.93 | +1.04 | buy |
| BlackRock, Inc. | 5,463,266 | 5,646,919 | +183,653 | 0.00 | 0.00 | +0.00 | buy |
| Nextech Invest, Ltd. | 5,533,980 | 5,533,980 | 0 | 5.36 | 7.08 | +1.71 | hold |
| VANGUARD GROUP INC | 4,026,800 | 5,052,003 | +1,025,203 | 0.00 | 0.00 | +0.00 | buy |
| GILEAD SCIENCES, INC. | 4,854,443 | 4,854,443 | 0 | 1.94 | 2.28 | +0.33 | hold |
| T. Rowe Price Investment Management, Inc. | 3,169,226 | 3,526,359 | +357,133 | 0.01 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,247,463 | 3,472,207 | +224,744 | 0.04 | 0.06 | +0.02 | buy |
| STATE STREET CORP | 1,382,686 | 3,365,205 | +1,982,519 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 3,086,184 | +3,086,184 | 0.00 | 0.77 | +0.77 | buy |
| Point72 Asset Management, L.P. | 0 | 2,919,450 | +2,919,450 | 0.00 | 0.05 | +0.05 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,712,008 | 2,712,008 | 0 | 1.74 | 1.51 | -0.23 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,905,349 | 2,511,000 | -3,394,349 | 0.05 | 0.03 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 2,302,274 | +2,302,274 | 0.00 | 0.01 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 2,000,000 | 2,000,000 | 0 | 0.17 | 0.21 | +0.03 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,768,913 | 1,882,777 | +113,864 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 3,439,594 | 1,809,948 | -1,629,646 | 1.25 | 0.94 | -0.31 | sell |
| GOLDMAN SACHS GROUP INC | 108,179 | 1,509,475 | +1,401,296 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 1,500,000 | 1,500,000 | 0 | 0.54 | 0.62 | +0.07 | hold |
| MARSHALL WACE, LLP | 1,742,691 | 1,489,518 | -253,173 | 0.01 | 0.01 | +0.00 | sell |
| Deep Track Capital, LP | 0 | 1,454,562 | +1,454,562 | 0.00 | 0.34 | +0.34 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,772,304 | 1,295,401 | -476,903 | 0.01 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 95,293 | 1,031,917 | +936,624 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 950,000 | +950,000 | 0.00 | 0.79 | +0.79 | buy |
| Nuveen, LLC | 442,963 | 928,012 | +485,049 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 125,207 | 926,904 | +801,697 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 600,000 | 776,699 | +176,699 | 0.31 | 0.53 | +0.21 | buy |
| Candriam S.C.A. | 708,812 | 708,812 | 0 | 0.02 | 0.03 | +0.01 | hold |
| BESSEMER GROUP INC | 708,384 | 708,398 | +14 | 0.01 | 0.01 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.07 | 0.11 | +0.05 | hold |
| DIMENSIONAL FUND ADVISORS LP | 525,098 | 672,735 | +147,637 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 601,447 | 658,292 | +56,845 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 600,508 | 605,561 | +5,053 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 0 | 545,000 | +545,000 | 0.00 | 0.06 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 0 | 430,379 | +430,379 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 423,851 | +423,851 | 0.00 | 0.03 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 384,207 | +384,207 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 138,650 | 365,680 | +227,030 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 730,000 | 300,000 | -430,000 | 0.26 | 0.13 | -0.12 | sell |
| ROYAL BANK OF CANADA | 252,273 | 287,499 | +35,226 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 253,288 | +253,288 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 534,621 | 251,793 | -282,828 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 208,800 | 245,378 | +36,578 | 0.34 | 0.42 | +0.07 | buy |
| READYSTATE ASSET MANAGEMENT LP | 418,517 | 245,109 | -173,408 | 0.09 | 0.10 | +0.01 | sell |
| Cubist Systematic Strategies, LLC | 0 | 240,655 | +240,655 | 0.00 | 0.03 | +0.03 | buy |
| FRED ALGER MANAGEMENT, LLC | 191,337 | 230,316 | +38,979 | 0.00 | 0.01 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 227,194 | 228,120 | +926 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 224,077 | 210,352 | -13,725 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 199,081 | +199,081 | 0.00 | 0.02 | +0.02 | buy |
| TRV GP VI, LLC | 194,174 | 194,174 | 0 | 1.55 | 1.49 | -0.06 | hold |
| Bank of New York Mellon Corp | 187,997 | 192,348 | +4,351 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 277,102 | 160,478 | -116,624 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 159,837 | 157,233 | -2,604 | 0.02 | 0.05 | +0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 155,447 | +155,447 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 145,316 | +145,316 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 22,218 | 144,432 | +122,214 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 814,416 | 119,416 | -695,000 | 1.35 | 0.31 | -1.03 | sell |
| RHUMBLINE ADVISERS | 112,273 | 107,839 | -4,434 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 106,010 | 102,270 | -3,740 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 94,100 | +94,100 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,447 | 88,839 | -153,608 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 81,238 | +81,238 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 78,946 | 79,175 | +229 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 52,661 | 59,149 | +6,488 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 65,500 | 55,300 | -10,200 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 49,217 | 55,005 | +5,788 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 53,572 | +53,572 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 47,726 | 47,726 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,401 | 40,669 | +2,268 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,998 | 40,398 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 36,963 | +36,963 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 36,189 | +36,189 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 39,500 | 36,000 | -3,500 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 0 | 35,244 | +35,244 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 66,675 | 33,916 | -32,759 | 0.00 | 0.00 | -0.00 | sell |
| Harvest Investment Services, LLC | 0 | 31,840 | +31,840 | 0.00 | 0.05 | +0.05 | buy |
| PROFUND ADVISORS LLC | 0 | 31,288 | +31,288 | 0.00 | 0.01 | +0.01 | buy |
| Clear Harbor Asset Management, LLC | 30,299 | 30,300 | +1 | 0.01 | 0.02 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 29,036 | +29,036 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 45,675 | 28,152 | -17,523 | 0.00 | 0.00 | -0.00 | sell |
| Simplicity Wealth,LLC | 26,961 | 26,961 | 0 | 0.01 | 0.01 | +0.01 | hold |
| EverSource Wealth Advisors, LLC | 26,631 | 26,653 | +22 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 24,752 | +24,752 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,805 | 22,694 | -6,111 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 18,620 | 22,532 | +3,912 | 0.03 | 0.05 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 125,000 | 21,500 | -103,500 | 0.02 | 0.00 | -0.01 | sell |
| Police & Firemen's Retirement System of New Jersey | 17,647 | 20,548 | +2,901 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 20,369 | 20,213 | -156 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 21,771 | 19,502 | -2,269 | 0.01 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 30,291 | 18,102 | -12,189 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 18,072 | +18,072 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 10,290 | 17,185 | +6,895 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 19,775 | 16,230 | -3,545 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,576 | 15,576 | +9,000 | 0.00 | 0.00 | +0.00 | buy |