| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 8,721,636 | 13,330,736 | +4,609,100 | 3.31 | 3.43 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,754,852 | 3,400,000 | +1,645,148 | 0.04 | 0.07 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 793,729 | 1,540,000 | +746,271 | 0.20 | 0.28 | +0.08 | buy |
| China Universal Asset Management Co., Ltd. | 2,263 | 11,793 | +9,530 | 0.01 | 0.02 | +0.02 | buy |
| Clear Harbor Asset Management, LLC | 20,131 | 21,200 | +1,069 | 0.02 | 0.02 | -0.00 | buy |
| LMR Partners LLP | 25,000 | 14,000 | -11,000 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 350,000 | 300,274 | -49,726 | 1.29 | 0.59 | -0.69 | sell |
| Parkman Healthcare Partners LLC | 135,920 | 65,679 | -70,241 | 0.28 | 0.09 | -0.19 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 143,481 | 55,814 | -87,667 | 0.01 | 0.00 | -0.01 | sell |
| Casdin Capital, LLC | 1,307,349 | 1,188,349 | -119,000 | 1.63 | 1.15 | -0.47 | sell |
| Soleus Capital Management, L.P. | 1,929,019 | 847,145 | -1,081,874 | 2.19 | 0.93 | -1.26 | sell |
| PERCEPTIVE ADVISORS LLC | 2,418,968 | 1,111,870 | -1,307,098 | 0.91 | 0.25 | -0.66 | sell |