| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 8,721,636 | 13,330,736 | +4,609,100 | 3.34 | 3.43 | +0.08 | buy |
| RTW INVESTMENTS, LP | 0 | 1,966,752 | +1,966,752 | 0.00 | 0.30 | +0.30 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,754,852 | 3,400,000 | +1,645,148 | 0.04 | 0.07 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 793,729 | 1,540,000 | +746,271 | 0.20 | 0.28 | +0.08 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 708,385 | +708,385 | 0.00 | 0.08 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 114,860 | 449,215 | +334,355 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 294,558 | +294,558 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 286,694 | +286,694 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 201,815 | +201,815 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 19,421 | 180,598 | +161,177 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 114,357 | +114,357 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 87,882 | 201,899 | +114,017 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 132,091 | 236,392 | +104,301 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 101,332 | +101,332 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 0 | 100,691 | +100,691 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 99,808 | +99,808 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 80,747 | 170,228 | +89,481 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 86,224 | +86,224 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 38,200 | 121,000 | +82,800 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 72,640 | +72,640 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,034,994 | 1,097,102 | +62,108 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 52,105 | +52,105 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 23,718 | 70,409 | +46,691 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,939,843 | 2,979,212 | +39,369 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Middle East FZE | 0 | 34,353 | +34,353 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 953,879 | 978,938 | +25,059 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 24,083 | +24,083 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 23,980 | +23,980 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 22,176 | +22,176 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 22,162 | +22,162 | 0.00 | 0.00 | +0.00 | buy |
| Old Well Partners, LLC | 0 | 18,400 | +18,400 | 0.00 | 0.17 | +0.17 | buy |
| Corton Capital Inc. | 0 | 17,766 | +17,766 | 0.00 | 0.06 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 0 | 15,413 | +15,413 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 41,294 | 56,400 | +15,106 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,750 | +13,750 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 13,745 | +13,745 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,370 | 22,096 | +12,726 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,073 | 13,902 | +11,829 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,448 | 13,209 | +11,761 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 401,441 | 412,404 | +10,963 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 10,752 | +10,752 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,263 | 11,793 | +9,530 | 0.01 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 0 | 9,086 | +9,086 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 28,160 | 36,640 | +8,480 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 51,956 | 59,796 | +7,840 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 1,218 | 8,163 | +6,945 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 20,653 | 26,226 | +5,573 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 12,297 | 16,474 | +4,177 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,071 | 13,788 | +2,717 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 47,252 | 49,803 | +2,551 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 11,582 | 13,906 | +2,324 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 367,357 | 369,066 | +1,709 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,838 | 26,416 | +1,578 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,216 | 11,345 | +1,129 | 0.00 | 0.00 | -0.00 | buy |
| Clear Harbor Asset Management, LLC | 20,131 | 21,200 | +1,069 | 0.02 | 0.02 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,498 | 4,378 | +880 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 69,766 | 70,390 | +624 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 21,368 | 21,836 | +468 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 464 | +464 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 18,046 | 18,449 | +403 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 170 | +170 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 156 | +156 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 3,512 | 3,656 | +144 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 0 | 14 | +14 | 0.00 | 0.00 | 0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 11,905 | 11,908 | +3 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| FISHMAN JAY A LTD/MI | 14,000 | 14,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| BESSEMER GROUP INC | 708,384 | 708,384 | 0 | 0.02 | 0.01 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.32 | 0.18 | -0.13 | hold |
| BAKER BROS. ADVISORS LP | 750,000 | 750,000 | 0 | 0.05 | 0.08 | +0.04 | hold |
| Southpoint Capital Advisors LP | 5,276,699 | 5,276,699 | 0 | 1.33 | 1.12 | -0.20 | hold |
| Janney Montgomery Scott LLC | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 495,213 | 495,213 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 355 | 355 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 25,780 | 25,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TRV GP IV, LLC | 19,363,975 | 19,363,975 | 0 | 82.15 | 77.88 | -4.26 | hold |
| Russell Investments Group, Ltd. | 31 | 31 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,892,663 | 2,892,663 | 0 | 3.64 | 2.74 | -0.90 | hold |
| Samsara BioCapital, LLC | 630,000 | 630,000 | 0 | 2.17 | 0.97 | -1.20 | hold |
| Alaethes Wealth, LLC | 20,000 | 20,000 | 0 | 0.12 | 0.09 | -0.03 | hold |
| DIMENSIONAL FUND ADVISORS LP | 59,914 | 59,914 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,484 | 2,484 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,200 | 12,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,080 | 18,080 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,780 | 12,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 22,279 | 22,190 | -89 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 4,489 | 4,007 | -482 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 25,189 | 24,629 | -560 | 0.00 | 0.00 | -0.00 | sell |
| Mascoma Wealth Management LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,055 | 25 | -1,030 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 13,019 | 11,377 | -1,642 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 39,922 | 36,407 | -3,515 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 23,900 | 18,200 | -5,700 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,284 | 43,548 | -6,736 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 8,157 | 0 | -8,157 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 25,000 | 14,000 | -11,000 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 12,715 | 0 | -12,715 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,522 | 0 | -13,522 | 0.00 | 0.00 | -0.00 | sell |