| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TRV GP IV, LLC | 16,859,075 | 16,859,075 | 0 | 80.09 | 64.97 | -15.12 | hold |
| TCG Crossover Management, LLC | 0 | 10,736,000 | +10,736,000 | 0.00 | 3.24 | +3.24 | buy |
| EcoR1 Capital, LLC | 13,330,736 | 10,630,736 | -2,700,000 | 3.52 | 1.31 | -2.20 | sell |
| BlackRock, Inc. | 4,361,335 | 4,378,503 | +17,168 | 0.00 | 0.00 | -0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 4,000,000 | +4,000,000 | 0.00 | 0.07 | +0.07 | buy |
| VANGUARD GROUP INC | 3,645,303 | 3,985,225 | +339,922 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 5,023,146 | 3,345,551 | -1,677,595 | 0.02 | 0.01 | -0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 2,687,196 | 3,279,196 | +592,000 | 0.05 | 0.02 | -0.03 | buy |
| Nantahala Capital Management, LLC | 0 | 2,804,410 | +2,804,410 | 0.00 | 0.61 | +0.61 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,712,008 | 2,712,008 | 0 | 2.17 | 0.99 | -1.19 | hold |
| Siren, L.L.C. | 2,603,897 | 2,603,897 | 0 | 1.00 | 0.36 | -0.65 | hold |
| Blue Owl Capital Holdings LP | 0 | 1,732,152 | +1,732,152 | 0.00 | 1.23 | +1.23 | buy |
| CITADEL ADVISORS LLC | 2,694,125 | 1,626,759 | -1,067,366 | 0.02 | 0.00 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,368,262 | 1,386,449 | +18,187 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 2,318,208 | 1,231,199 | -1,087,009 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 1,188,349 | 1,188,349 | 0 | 0.61 | 0.25 | -0.36 | hold |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.07 | 0.03 | -0.04 | hold |
| BESSEMER GROUP INC | 708,384 | 708,384 | 0 | 0.01 | 0.00 | -0.01 | hold |
| DIMENSIONAL FUND ADVISORS LP | 360,689 | 662,776 | +302,087 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 655,158 | +655,158 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 630,000 | 630,000 | 0 | 0.93 | 0.27 | -0.67 | hold |
| ORBIMED ADVISORS LLC | 0 | 550,000 | +550,000 | 0.00 | 0.04 | +0.04 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 517,426 | +517,426 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 487,237 | 513,429 | +26,192 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 479,250 | 513,079 | +33,829 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 495,106 | +495,106 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 543,497 | 486,888 | -56,609 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 599,048 | 474,955 | -124,093 | 4.12 | 1.29 | -2.84 | sell |
| UBS Group AG | 440,831 | 414,473 | -26,358 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 0 | 394,397 | +394,397 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 62,417 | 347,271 | +284,854 | 0.01 | 0.02 | +0.01 | buy |
| Walleye Capital LLC | 142,576 | 287,052 | +144,476 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 175,369 | 272,233 | +96,864 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 249,646 | +249,646 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 209,070 | 227,989 | +18,919 | 0.01 | 0.00 | -0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 162,300 | +162,300 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 154,947 | 154,947 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 143,207 | 138,247 | -4,960 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 16,427 | 126,553 | +110,126 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 121,993 | +121,993 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 114,827 | +114,827 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 98,286 | 110,448 | +12,162 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 111,735 | 103,020 | -8,715 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 0 | 102,807 | +102,807 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 126,281 | 99,774 | -26,507 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 50,764 | 95,229 | +44,465 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 83,900 | 94,900 | +11,000 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 45,272 | 86,445 | +41,173 | 0.03 | 0.02 | -0.01 | buy |
| Verition Fund Management LLC | 32,020 | 81,045 | +49,025 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 44,191 | 77,937 | +33,746 | 0.02 | 0.02 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,302 | 76,551 | +1,249 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 70,452 | +70,452 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 63,845 | 65,740 | +1,895 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 64,940 | 64,940 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aristides Capital LLC | 0 | 64,300 | +64,300 | 0.00 | 0.06 | +0.06 | buy |
| TUDOR INVESTMENT CORP ET AL | 63,296 | 60,614 | -2,682 | 0.01 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 28,619 | 57,319 | +28,700 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 10,901 | 51,924 | +41,023 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 38,676 | 46,992 | +8,316 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,767 | 45,015 | +4,248 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 68,162 | 44,996 | -23,166 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 37,961 | 37,961 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 29,525 | 36,653 | +7,128 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 34,804 | +34,804 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 52,840 | 31,313 | -21,527 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 31,146 | +31,146 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 28,950 | 29,534 | +584 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 30,910 | 27,919 | -2,991 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,297 | 27,411 | -2,886 | 0.00 | 0.00 | -0.00 | sell |
| Simplicity Wealth,LLC | 26,961 | 26,961 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Catalina Capital Group, LLC | 0 | 26,593 | +26,593 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 26,200 | +26,200 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 25,495 | 25,495 | 0 | 0.02 | 0.01 | -0.01 | hold |
| VIRTUS ADVISERS, LLC | 10,984 | 24,945 | +13,961 | 0.04 | 0.03 | -0.01 | buy |
| Corton Capital Inc. | 0 | 24,408 | +24,408 | 0.00 | 0.04 | +0.04 | buy |
| Corebridge Financial, Inc. | 25,509 | 23,719 | -1,790 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 20,607 | 22,777 | +2,170 | 0.02 | 0.01 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 14,693 | 22,292 | +7,599 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 19,644 | 21,963 | +2,319 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 21,500 | +21,500 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,185 | 20,998 | +4,813 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 28,264 | 19,631 | -8,633 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,227 | 19,296 | +69 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 15,346 | 18,524 | +3,178 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 17,426 | 17,426 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 16,311 | 15,149 | -1,162 | 0.00 | 0.00 | -0.00 | sell |
| Sequoia Financial Advisors, LLC | 0 | 14,631 | +14,631 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,713 | 14,544 | +3,831 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 12,306 | 13,976 | +1,670 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,826 | 13,494 | -332 | 0.00 | 0.00 | -0.00 | sell |
| Bleakley Financial Group, LLC | 14,427 | 12,849 | -1,578 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 12,843 | +12,843 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,780 | 12,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHERBROOKE PARK ADVISERS LLC | 0 | 12,307 | +12,307 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 11,631 | 11,631 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 0 | 11,198 | +11,198 | 0.00 | 0.00 | +0.00 | buy |
| Stonebrook Private Inc. | 0 | 10,992 | +10,992 | 0.00 | 0.01 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 10,764 | +10,764 | 0.00 | 0.01 | +0.01 | buy |